Brain Metastases from Gynecologic Malignancies
<i>Background and Objectives</i>: To present a series of brain metastases from gynecologic primaries and provide a summary of the relevant literature. <i>Materials and Methods</i>: We retrospectively review 18 patients with histologically confirmed brain metastases from gynec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
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| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/58/4/548 |
| Summary: | <i>Background and Objectives</i>: To present a series of brain metastases from gynecologic primaries and provide a summary of the relevant literature. <i>Materials and Methods</i>: We retrospectively review 18 patients with histologically confirmed brain metastases from gynecologic primaries and summarize the largest series of relative reports. <i>Results</i>: Six brain metastases were of endometrial primary and 12 of ovarian primary. In 3 cases (16.7%), diagnosis of brain metastases was made at presentation of the gynecologic primary; in the others, median time to development of brain metastasis was 34 (range, 6–115) months. Median survival after brain metastasis diagnosis was 5 (range, 1–89) months. Favorable prognostic factors were better performance status (<i>p</i> = 0.04) and, marginally, smaller metastasis size (<i>p</i> = 0.06). No differences in brain metastases between endometrial and ovarian primaries were found, except for the time interval from primary to brain metastases diagnosis, which was shorter for endometrial tumors (<i>p</i> = 0.05). A comprehensive summary of previous studies is provided. <i>Conclusions</i>: Performance status and smaller brain metastases size are good prognostic factors. Endometrial cancer brain metastases develop earlier than ovarian cancer brain metastases. |
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| ISSN: | 1010-660X 1648-9144 |