Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11
ObjectiveWe report the effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11.Case reportA 45 years-old Chinese woman presented with an abnormally low HbA1c level of 3.7% (3.9%–6.1%) in a health examination. Fasting blood glucose was normal. Blood routine examination and serum bilirubi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1217662/full |
| _version_ | 1797755752211808256 |
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| author | Wei Gao Wenyu Li Qian Zheng Nenggang Jiang Huairong Tang |
| author_facet | Wei Gao Wenyu Li Qian Zheng Nenggang Jiang Huairong Tang |
| author_sort | Wei Gao |
| collection | DOAJ |
| description | ObjectiveWe report the effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11.Case reportA 45 years-old Chinese woman presented with an abnormally low HbA1c level of 3.7% (3.9%–6.1%) in a health examination. Fasting blood glucose was normal. Blood routine examination and serum bilirubin were in the normal range. HbA1c was determined by Tosoh HLC-723G11. There was an abnormal peak between A1c and A0 on the chromatogram. Hemoglobin electrophoresis indicated that the Hb E zone accounted for 25.1%. The β-thalassemia-related genes (mutant type) were βE M/N, and the related gene CD26 (A > G) was mutated. OGTT indicated prediabetes.ConclusionHb E heterozygosity may reduce HbA1c value with abnormal chromatograms, as determined by a Tosoh HLC G11 analyzer. The Tosoh HLC G11 analyzer can well identify Hb E variation. In this case, further blood glucose-related tests should be performed to avoid missed diagnoses. However, a large sample size is needed to confirm this conclusion. |
| first_indexed | 2024-03-12T17:50:44Z |
| format | Article |
| id | doaj.art-9674a9824c2d479ebb7394f8dc9bf90e |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-12T17:50:44Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-9674a9824c2d479ebb7394f8dc9bf90e2023-08-03T08:16:44ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-08-011110.3389/fpubh.2023.12176621217662Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11Wei Gao0Wenyu Li1Qian Zheng2Nenggang Jiang3Huairong Tang4Health Management Center, General Practice Center, West China Hospital, Sichuan University, Chengdu, ChinaHealth Management Center, General Practice Center, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, ChinaHealth Management Center, General Practice Center, West China Hospital, Sichuan University, Chengdu, ChinaObjectiveWe report the effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11.Case reportA 45 years-old Chinese woman presented with an abnormally low HbA1c level of 3.7% (3.9%–6.1%) in a health examination. Fasting blood glucose was normal. Blood routine examination and serum bilirubin were in the normal range. HbA1c was determined by Tosoh HLC-723G11. There was an abnormal peak between A1c and A0 on the chromatogram. Hemoglobin electrophoresis indicated that the Hb E zone accounted for 25.1%. The β-thalassemia-related genes (mutant type) were βE M/N, and the related gene CD26 (A > G) was mutated. OGTT indicated prediabetes.ConclusionHb E heterozygosity may reduce HbA1c value with abnormal chromatograms, as determined by a Tosoh HLC G11 analyzer. The Tosoh HLC G11 analyzer can well identify Hb E variation. In this case, further blood glucose-related tests should be performed to avoid missed diagnoses. However, a large sample size is needed to confirm this conclusion.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1217662/fullHbA1cHb Eheterozygosityhigh-pressure liquid chromatographyTosoh HLC-723G11 |
| spellingShingle | Wei Gao Wenyu Li Qian Zheng Nenggang Jiang Huairong Tang Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11 Frontiers in Public Health HbA1c Hb E heterozygosity high-pressure liquid chromatography Tosoh HLC-723G11 |
| title | Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11 |
| title_full | Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11 |
| title_fullStr | Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11 |
| title_full_unstemmed | Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11 |
| title_short | Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11 |
| title_sort | case report effect of hb e heterozygosity on hba1c value by the tosoh hlc 723g11 |
| topic | HbA1c Hb E heterozygosity high-pressure liquid chromatography Tosoh HLC-723G11 |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1217662/full |
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