Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice

Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice

The perinuclear theca (PT) is a dense cytoplasmic web encapsulating the sperm nucleus. The physiological roles of PT in sperm biology and the clinical relevance of variants of PT proteins to male infertility are still largely unknown. We reveal that cylicin-1, a major constituent of the PT, is vital...

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Bibliographic Details
Main Authors: Hui-Juan Jin, Yong Fan, Xiaoyu Yang, Yue Dong, Xiao-Zhen Zhang, Xin-Yan Geng, Zheng Yan, Ling Wu, Meng Ma, Bin Li, Qifeng Lyu, Yun Pan, Mingxi Liu, Yanping Kuang, Su-Ren Chen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-04-01
Series:eLife
Subjects:
perinuclear theca
CYLC1
male infertility
sperm head deformity
acrosome detachment
Online Access:https://elifesciences.org/articles/95054

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