The role of connexins in wound healing and repair: novel therapeutic approaches
Gap junctions are intercellular proteins responsible for mediating both electrical and biochemical coupling through the exchange of ions, second messengers and small metabolites. They are made of two connexons, with each (one) connexon supplied by each cell. A connexon consists of a hexamer of conne...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-12-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00596/full |
| _version_ | 1819176655768256512 |
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| author | Jeremy Wong Teresa Tan Catherine Chan Victoria Laxton Yin Wah Fiona Chan Tong Liu Jack Wong Gary Tse |
| author_facet | Jeremy Wong Teresa Tan Catherine Chan Victoria Laxton Yin Wah Fiona Chan Tong Liu Jack Wong Gary Tse |
| author_sort | Jeremy Wong |
| collection | DOAJ |
| description | Gap junctions are intercellular proteins responsible for mediating both electrical and biochemical coupling through the exchange of ions, second messengers and small metabolites. They are made of two connexons, with each (one) connexon supplied by each cell. A connexon consists of a hexamer of connexins with m. More than 20 connexin isoforms have been described in the literature thus far. Connexins have a short half-life, and therefore gap junction remodelling constantly occurs with a high turnover rate. Connexins undergo post-translational modification, such as phosphorylation, which can modify their channel activities. In this article, the roles of connexins in wound healing and repair are explored. We also consider nNovel strategies for modulating the function or expression of connexins, such as the use of antisense technology, synthetic mimetic peptides and bioactive materials, for the treatment of skin wounds, diabetic and pressure ulcers as well as cornea wounds. are considered. |
| first_indexed | 2024-12-22T21:14:13Z |
| format | Article |
| id | doaj.art-9677743a30ea4ce098467f9dfec169fc |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-22T21:14:13Z |
| publishDate | 2016-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-9677743a30ea4ce098467f9dfec169fc2022-12-21T18:12:24ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2016-12-01710.3389/fphys.2016.00596222604The role of connexins in wound healing and repair: novel therapeutic approachesJeremy Wong0Teresa Tan1Catherine Chan2Victoria Laxton3Yin Wah Fiona Chan4Tong Liu5Jack Wong6Gary Tse7University of Hong KongCUHKCUHKRoyal BromptonUniversity of CambridgeTianjin Institute of CardiologyCUHKChinese University of Hong KongGap junctions are intercellular proteins responsible for mediating both electrical and biochemical coupling through the exchange of ions, second messengers and small metabolites. They are made of two connexons, with each (one) connexon supplied by each cell. A connexon consists of a hexamer of connexins with m. More than 20 connexin isoforms have been described in the literature thus far. Connexins have a short half-life, and therefore gap junction remodelling constantly occurs with a high turnover rate. Connexins undergo post-translational modification, such as phosphorylation, which can modify their channel activities. In this article, the roles of connexins in wound healing and repair are explored. We also consider nNovel strategies for modulating the function or expression of connexins, such as the use of antisense technology, synthetic mimetic peptides and bioactive materials, for the treatment of skin wounds, diabetic and pressure ulcers as well as cornea wounds. are considered.http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00596/fullConnexinsGap JunctionsWound Healingwound repairAntisense oligodeoxynucleotidesconnexin mimetic peptides |
| spellingShingle | Jeremy Wong Teresa Tan Catherine Chan Victoria Laxton Yin Wah Fiona Chan Tong Liu Jack Wong Gary Tse The role of connexins in wound healing and repair: novel therapeutic approaches Frontiers in Physiology Connexins Gap Junctions Wound Healing wound repair Antisense oligodeoxynucleotides connexin mimetic peptides |
| title | The role of connexins in wound healing and repair: novel therapeutic approaches |
| title_full | The role of connexins in wound healing and repair: novel therapeutic approaches |
| title_fullStr | The role of connexins in wound healing and repair: novel therapeutic approaches |
| title_full_unstemmed | The role of connexins in wound healing and repair: novel therapeutic approaches |
| title_short | The role of connexins in wound healing and repair: novel therapeutic approaches |
| title_sort | role of connexins in wound healing and repair novel therapeutic approaches |
| topic | Connexins Gap Junctions Wound Healing wound repair Antisense oligodeoxynucleotides connexin mimetic peptides |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00596/full |
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