Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL
Abstract Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) manifests principally as a suite of cognitive impairments, particularly in the executive domain. Executive functioning requires the dynamic coordination of neural activity over la...
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s10194-019-1052-6 |
| _version_ | 1818218446292254720 |
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| author | Jingjing Su Shiyu Ban Mengxing Wang Fengchun Hua Liang Wang Xin Cheng Yuping Tang Houguang Zhou Yu Zhai Xiaoxia Du Jianren Liu |
| author_facet | Jingjing Su Shiyu Ban Mengxing Wang Fengchun Hua Liang Wang Xin Cheng Yuping Tang Houguang Zhou Yu Zhai Xiaoxia Du Jianren Liu |
| author_sort | Jingjing Su |
| collection | DOAJ |
| description | Abstract Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) manifests principally as a suite of cognitive impairments, particularly in the executive domain. Executive functioning requires the dynamic coordination of neural activity over large-scale networks. It remains unclear whether changes in resting-state brain functional network connectivity and regional homogeneities (ReHos) underly the mechanisms of executive dysfunction evident in CADASIL patients. Methods In this study, 22 CADASIL patients and 44 matched healthy controls underwent resting-state functional magnetic resonance imaging (fMRI). Independent component analysis (ICA) was used to measure functional brain network connectivity, and ReHos were calculated to evaluate local brain activities. We used seed-based functional connectivity (FC) analyses to determine whether dysfunctional areas (as defined by ReHos) exhibited abnormal FC with other brain areas. Relationships among the mean intra-network connectivity z-scores of dysfunctional areas within functional networks, and cognitive scores were evaluated using Pearson correlation analyses. Results Compared to the controls, CADASIL patients exhibited decreased intra-network connectivity within the bilateral lingual gyrus (LG) and the right cuneus (CU) (thus within the visual network [VIN)], and within the right precuneus (Pcu), inferior frontal gyrus (IFG), and precentral gyrus (thus within the frontal network [FRN]). Compared to the controls, patients also exhibited significantly lower ReHos in the right precuneus and cuneus (Pcu/CU), visual association cortex, calcarine gyri, posterior cingulate, limbic lobe, and weaker FC between the right Pcu/CU and the bilateral parahippocampal gyrus (PHG), and between the right Pcu/CU and the right postcentral gyrus. Notably, the mean connectivity z-scores of the bilateral LG and the right CU within the VIN were positively associated with compromised attention, calculation and delayed recall as revealed by tests of the various cognitive domains explored by the Mini-Mental State Examination. Conclusions The decreases in intra-network connectivity within the VIN and FRN and reduced local brain activity in the posterior parietal area suggest that patients with CADASIL may exhibit dysfunctional visuomotor behaviors (a hallmark of executive function), and that all visual information processing, visuomotor planning, and movement execution may be affected. |
| first_indexed | 2024-12-12T07:23:53Z |
| format | Article |
| id | doaj.art-967a6baf2c3744069f486cf0b44da5c7 |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-12-12T07:23:53Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-967a6baf2c3744069f486cf0b44da5c72022-12-22T00:33:14ZengBMCThe Journal of Headache and Pain1129-23691129-23772019-11-0120111210.1186/s10194-019-1052-6Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASILJingjing Su0Shiyu Ban1Mengxing Wang2Fengchun Hua3Liang Wang4Xin Cheng5Yuping Tang6Houguang Zhou7Yu Zhai8Xiaoxia Du9Jianren Liu10Department of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal UniversityShanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal UniversityPET Center, Huashan Hospital, Fudan UniversityDepartment of Neurology, Huashan Hospital, Fudan UniversityDepartment of Neurology, Huashan Hospital, Fudan UniversityDepartment of Neurology, Huashan Hospital, Fudan UniversityDepartment of Geriatrics Neurology, Huashan Hospital, Fudan UniversityDepartment of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal UniversityDepartment of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineAbstract Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) manifests principally as a suite of cognitive impairments, particularly in the executive domain. Executive functioning requires the dynamic coordination of neural activity over large-scale networks. It remains unclear whether changes in resting-state brain functional network connectivity and regional homogeneities (ReHos) underly the mechanisms of executive dysfunction evident in CADASIL patients. Methods In this study, 22 CADASIL patients and 44 matched healthy controls underwent resting-state functional magnetic resonance imaging (fMRI). Independent component analysis (ICA) was used to measure functional brain network connectivity, and ReHos were calculated to evaluate local brain activities. We used seed-based functional connectivity (FC) analyses to determine whether dysfunctional areas (as defined by ReHos) exhibited abnormal FC with other brain areas. Relationships among the mean intra-network connectivity z-scores of dysfunctional areas within functional networks, and cognitive scores were evaluated using Pearson correlation analyses. Results Compared to the controls, CADASIL patients exhibited decreased intra-network connectivity within the bilateral lingual gyrus (LG) and the right cuneus (CU) (thus within the visual network [VIN)], and within the right precuneus (Pcu), inferior frontal gyrus (IFG), and precentral gyrus (thus within the frontal network [FRN]). Compared to the controls, patients also exhibited significantly lower ReHos in the right precuneus and cuneus (Pcu/CU), visual association cortex, calcarine gyri, posterior cingulate, limbic lobe, and weaker FC between the right Pcu/CU and the bilateral parahippocampal gyrus (PHG), and between the right Pcu/CU and the right postcentral gyrus. Notably, the mean connectivity z-scores of the bilateral LG and the right CU within the VIN were positively associated with compromised attention, calculation and delayed recall as revealed by tests of the various cognitive domains explored by the Mini-Mental State Examination. Conclusions The decreases in intra-network connectivity within the VIN and FRN and reduced local brain activity in the posterior parietal area suggest that patients with CADASIL may exhibit dysfunctional visuomotor behaviors (a hallmark of executive function), and that all visual information processing, visuomotor planning, and movement execution may be affected.http://link.springer.com/article/10.1186/s10194-019-1052-6Functional network connectivityRegional homogeneityCADASILResting-state fMRIVisuomotor behaviors |
| spellingShingle | Jingjing Su Shiyu Ban Mengxing Wang Fengchun Hua Liang Wang Xin Cheng Yuping Tang Houguang Zhou Yu Zhai Xiaoxia Du Jianren Liu Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL The Journal of Headache and Pain Functional network connectivity Regional homogeneity CADASIL Resting-state fMRI Visuomotor behaviors |
| title | Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL |
| title_full | Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL |
| title_fullStr | Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL |
| title_full_unstemmed | Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL |
| title_short | Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL |
| title_sort | reduced resting state brain functional network connectivity and poor regional homogeneity in patients with cadasil |
| topic | Functional network connectivity Regional homogeneity CADASIL Resting-state fMRI Visuomotor behaviors |
| url | http://link.springer.com/article/10.1186/s10194-019-1052-6 |
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