Evaluation of Different Doses of Prilocaine in Inguinal Hernial Repair Surgeries: A Prospective Randomized Trial
Background: Inguinal hernia repair involves more than 20 million patients annually worldwide. Most of the inguinal hernia surgical procedures are performed on outpatients. Prilocaine has a relatively rapid onset and short duration of action which makes it more suitable for outpatient surgeries with...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Al-Azhar University, Faculty of Medicine (Damietta)
2022-10-01
|
| Series: | International Journal of Medical Arts |
| Subjects: | |
| Online Access: | https://ijma.journals.ekb.eg/article_278948_ea324ee9c45e310300ef50f92e150217.pdf |
| _version_ | 1827389351143669760 |
|---|---|
| author | Ahmed El-Sayed Tawfik Noor El-Deen Adel Diab Mohammed Abd-Elhalim |
| author_facet | Ahmed El-Sayed Tawfik Noor El-Deen Adel Diab Mohammed Abd-Elhalim |
| author_sort | Ahmed El-Sayed |
| collection | DOAJ |
| description | Background: Inguinal hernia repair involves more than 20 million patients annually worldwide. Most of the inguinal hernia surgical procedures are performed on outpatients. Prilocaine has a relatively rapid onset and short duration of action which makes it more suitable for outpatient surgeries with relatively fewer effects on hemodynamics.Aim of the work: The primary outcome of this study is to evaluate hemodynamic changes and the secondary outcomes is to compare the efficacy of block [onset of sensory block, onset and intensity of motor block and duration of action], using three different doses of Prilocaine. Patients and methods: A prospective randomized comparative double-blind clinical trial included 60 patients underwent elective inguinal hernia repair. Patients were randomly classified into three groups [20 patients in each] and received spinal anesthesia with three different doses of Prilocaine [low dose 40 mg, medium dose 60 mg and high dose 80 mg]. Hemodynamics and efficacy of the block were measured.Results: There was a statistically significant decrease of systolic [p-value =0.001] and diastolic blood pressure [p-value =0.033] with high dose Prilocaine. Also, a statistically significant drop in heart rate [p-value=0.017] and early reduce of oxygen saturation [p-value=0.027] with high dose Prilocaine compared to low and medium doses. On the other hand, high dose Prilocaine was associated with faster sensory and more block and was faster to reach maximum block level.Conclusion: From this study, we can conclude that the use of low and medium doses of Prilocaine [40 and 60 mg] was associated with more hemodynamic stability. In spite of high dose of Prilocaine [80 mg] associated with less hemodynamic stability, it showed better motor and sensory block. |
| first_indexed | 2024-03-08T16:35:27Z |
| format | Article |
| id | doaj.art-967aba782cee496b9413a65cc92aec1a |
| institution | Directory Open Access Journal |
| issn | 2636-4174 2682-3780 |
| language | English |
| last_indexed | 2024-03-08T16:35:27Z |
| publishDate | 2022-10-01 |
| publisher | Al-Azhar University, Faculty of Medicine (Damietta) |
| record_format | Article |
| series | International Journal of Medical Arts |
| spelling | doaj.art-967aba782cee496b9413a65cc92aec1a2024-01-05T19:38:04ZengAl-Azhar University, Faculty of Medicine (Damietta)International Journal of Medical Arts2636-41742682-37802022-10-014102718272410.21608/ijma.2023.165498.1520278948Evaluation of Different Doses of Prilocaine in Inguinal Hernial Repair Surgeries: A Prospective Randomized TrialAhmed El-Sayed0Tawfik Noor El-Deen1Adel Diab2Mohammed Abd-Elhalim3Department of Anesthesia, Intensive Care and Pain Management, Damietta Faculty of Medicine, Al-Azhar University, Damietta, EgyptDepartment of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.Department of Anesthesia, Intensive Care and Pain Management, Damietta Faculty of Medicine, Al-Azhar University, Damietta, EgyptDepartment of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Al-Azhar University, Cairo, EgyptBackground: Inguinal hernia repair involves more than 20 million patients annually worldwide. Most of the inguinal hernia surgical procedures are performed on outpatients. Prilocaine has a relatively rapid onset and short duration of action which makes it more suitable for outpatient surgeries with relatively fewer effects on hemodynamics.Aim of the work: The primary outcome of this study is to evaluate hemodynamic changes and the secondary outcomes is to compare the efficacy of block [onset of sensory block, onset and intensity of motor block and duration of action], using three different doses of Prilocaine. Patients and methods: A prospective randomized comparative double-blind clinical trial included 60 patients underwent elective inguinal hernia repair. Patients were randomly classified into three groups [20 patients in each] and received spinal anesthesia with three different doses of Prilocaine [low dose 40 mg, medium dose 60 mg and high dose 80 mg]. Hemodynamics and efficacy of the block were measured.Results: There was a statistically significant decrease of systolic [p-value =0.001] and diastolic blood pressure [p-value =0.033] with high dose Prilocaine. Also, a statistically significant drop in heart rate [p-value=0.017] and early reduce of oxygen saturation [p-value=0.027] with high dose Prilocaine compared to low and medium doses. On the other hand, high dose Prilocaine was associated with faster sensory and more block and was faster to reach maximum block level.Conclusion: From this study, we can conclude that the use of low and medium doses of Prilocaine [40 and 60 mg] was associated with more hemodynamic stability. In spite of high dose of Prilocaine [80 mg] associated with less hemodynamic stability, it showed better motor and sensory block.https://ijma.journals.ekb.eg/article_278948_ea324ee9c45e310300ef50f92e150217.pdfprilocaineherniamotor blockhemodynamic |
| spellingShingle | Ahmed El-Sayed Tawfik Noor El-Deen Adel Diab Mohammed Abd-Elhalim Evaluation of Different Doses of Prilocaine in Inguinal Hernial Repair Surgeries: A Prospective Randomized Trial International Journal of Medical Arts prilocaine hernia motor block hemodynamic |
| title | Evaluation of Different Doses of Prilocaine in Inguinal Hernial Repair Surgeries: A Prospective Randomized Trial |
| title_full | Evaluation of Different Doses of Prilocaine in Inguinal Hernial Repair Surgeries: A Prospective Randomized Trial |
| title_fullStr | Evaluation of Different Doses of Prilocaine in Inguinal Hernial Repair Surgeries: A Prospective Randomized Trial |
| title_full_unstemmed | Evaluation of Different Doses of Prilocaine in Inguinal Hernial Repair Surgeries: A Prospective Randomized Trial |
| title_short | Evaluation of Different Doses of Prilocaine in Inguinal Hernial Repair Surgeries: A Prospective Randomized Trial |
| title_sort | evaluation of different doses of prilocaine in inguinal hernial repair surgeries a prospective randomized trial |
| topic | prilocaine hernia motor block hemodynamic |
| url | https://ijma.journals.ekb.eg/article_278948_ea324ee9c45e310300ef50f92e150217.pdf |
| work_keys_str_mv | AT ahmedelsayed evaluationofdifferentdosesofprilocaineininguinalhernialrepairsurgeriesaprospectiverandomizedtrial AT tawfiknooreldeen evaluationofdifferentdosesofprilocaineininguinalhernialrepairsurgeriesaprospectiverandomizedtrial AT adeldiab evaluationofdifferentdosesofprilocaineininguinalhernialrepairsurgeriesaprospectiverandomizedtrial AT mohammedabdelhalim evaluationofdifferentdosesofprilocaineininguinalhernialrepairsurgeriesaprospectiverandomizedtrial |