Role of neurotoxicants in the pathogenesis of Alzheimer’s disease: a mechanistic insight
AbstractAlzheimer’s disease (AD) is the most conspicuous chronic neurodegenerative syndrome, which has become a significant challenge for the global healthcare system. Multiple studies have corroborated a clear association of neurotoxicants with AD pathogenicity, such as Amyloid beta (Aβ) proteins a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2021.1966088 |
| _version_ | 1797385711742091264 |
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| author | Fatema Yasmin Nisa Md. Atiar Rahman Md. Amjad Hossen Mohammad Forhad Khan Md. Asif Nadim Khan Mumtahina Majid Farjana Sultana Md. Areeful Haque |
| author_facet | Fatema Yasmin Nisa Md. Atiar Rahman Md. Amjad Hossen Mohammad Forhad Khan Md. Asif Nadim Khan Mumtahina Majid Farjana Sultana Md. Areeful Haque |
| author_sort | Fatema Yasmin Nisa |
| collection | DOAJ |
| description | AbstractAlzheimer’s disease (AD) is the most conspicuous chronic neurodegenerative syndrome, which has become a significant challenge for the global healthcare system. Multiple studies have corroborated a clear association of neurotoxicants with AD pathogenicity, such as Amyloid beta (Aβ) proteins and neurofibrillary tangles (NFTs), signalling pathway modifications, cellular stress, cognitive dysfunctions, neuronal apoptosis, neuroinflammation, epigenetic modification, and so on. This review, therefore, aimed to address several essential mechanisms and signalling cascades, including Wnt (wingless and int.) signalling pathway, autophagy, mammalian target of rapamycin (mTOR), protein kinase C (PKC) signalling cascades, cellular redox status, energy metabolism, glutamatergic neurotransmissions, immune cell stimulations (e.g. microglia, astrocytes) as well as an amyloid precursor protein (APP), presenilin-1 (PSEN1), presenilin-2 (PSEN2) and other AD-related gene expressions that have been pretentious and modulated by the various neurotoxicants. This review concluded that neurotoxicants play a momentous role in developing AD through modulating various signalling cascades. Nevertheless, comprehension of this risk agent-induced neurotoxicity is far too little. More in-depth epidemiological and systematic investigations are needed to understand the potential mechanisms better to address these neurotoxicants and improve approaches to their risk exposure that aid in AD pathogenesis.Key messagesInevitable cascade mechanisms of how Alzheimer’s Disease-related (AD-related) gene expressions are modulated by neurotoxicants have been discussed.Involvement of the neurotoxicants-induced pathways caused an extended risk of AD is explicited.Integration of cell culture, animals and population-based analysis on the clinical severity of AD is addressed. |
| first_indexed | 2024-03-08T21:58:12Z |
| format | Article |
| id | doaj.art-967c6775c51840f8aee9c3e25fbd22d6 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T21:58:12Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-967c6775c51840f8aee9c3e25fbd22d62023-12-19T16:46:27ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602021-01-015311479150410.1080/07853890.2021.1966088Role of neurotoxicants in the pathogenesis of Alzheimer’s disease: a mechanistic insightFatema Yasmin Nisa0Md. Atiar Rahman1Md. Amjad Hossen2Mohammad Forhad Khan3Md. Asif Nadim Khan4Mumtahina Majid5Farjana Sultana6Md. Areeful Haque7Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Chittagong, Chittagong, BangladeshDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Chittagong, Chittagong, BangladeshDepartment of Pharmacy, International Islamic University Chittagong, Chittagong, BangladeshDepartment of Pharmacy, International Islamic University Chittagong, Chittagong, BangladeshDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Chittagong, Chittagong, BangladeshDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Chittagong, Chittagong, BangladeshDepartment of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Chittagong, Chittagong, BangladeshDepartment of Pharmacy, International Islamic University Chittagong, Chittagong, BangladeshAbstractAlzheimer’s disease (AD) is the most conspicuous chronic neurodegenerative syndrome, which has become a significant challenge for the global healthcare system. Multiple studies have corroborated a clear association of neurotoxicants with AD pathogenicity, such as Amyloid beta (Aβ) proteins and neurofibrillary tangles (NFTs), signalling pathway modifications, cellular stress, cognitive dysfunctions, neuronal apoptosis, neuroinflammation, epigenetic modification, and so on. This review, therefore, aimed to address several essential mechanisms and signalling cascades, including Wnt (wingless and int.) signalling pathway, autophagy, mammalian target of rapamycin (mTOR), protein kinase C (PKC) signalling cascades, cellular redox status, energy metabolism, glutamatergic neurotransmissions, immune cell stimulations (e.g. microglia, astrocytes) as well as an amyloid precursor protein (APP), presenilin-1 (PSEN1), presenilin-2 (PSEN2) and other AD-related gene expressions that have been pretentious and modulated by the various neurotoxicants. This review concluded that neurotoxicants play a momentous role in developing AD through modulating various signalling cascades. Nevertheless, comprehension of this risk agent-induced neurotoxicity is far too little. More in-depth epidemiological and systematic investigations are needed to understand the potential mechanisms better to address these neurotoxicants and improve approaches to their risk exposure that aid in AD pathogenesis.Key messagesInevitable cascade mechanisms of how Alzheimer’s Disease-related (AD-related) gene expressions are modulated by neurotoxicants have been discussed.Involvement of the neurotoxicants-induced pathways caused an extended risk of AD is explicited.Integration of cell culture, animals and population-based analysis on the clinical severity of AD is addressed.https://www.tandfonline.com/doi/10.1080/07853890.2021.1966088NeurotoxicantsAlzheimer’s diseaseoxidative stressneurodegenerationtoxic metals |
| spellingShingle | Fatema Yasmin Nisa Md. Atiar Rahman Md. Amjad Hossen Mohammad Forhad Khan Md. Asif Nadim Khan Mumtahina Majid Farjana Sultana Md. Areeful Haque Role of neurotoxicants in the pathogenesis of Alzheimer’s disease: a mechanistic insight Annals of Medicine Neurotoxicants Alzheimer’s disease oxidative stress neurodegeneration toxic metals |
| title | Role of neurotoxicants in the pathogenesis of Alzheimer’s disease: a mechanistic insight |
| title_full | Role of neurotoxicants in the pathogenesis of Alzheimer’s disease: a mechanistic insight |
| title_fullStr | Role of neurotoxicants in the pathogenesis of Alzheimer’s disease: a mechanistic insight |
| title_full_unstemmed | Role of neurotoxicants in the pathogenesis of Alzheimer’s disease: a mechanistic insight |
| title_short | Role of neurotoxicants in the pathogenesis of Alzheimer’s disease: a mechanistic insight |
| title_sort | role of neurotoxicants in the pathogenesis of alzheimer s disease a mechanistic insight |
| topic | Neurotoxicants Alzheimer’s disease oxidative stress neurodegeneration toxic metals |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2021.1966088 |
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