Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH)
Ectopic lipid accumulation and inflammation are the essential signs of NASH. Here, the authors show that hepatic WTAP is a key integrative repressor of ectopic lipid accumulation and inflammation during NASH progression, and hepatic deletion of Wtap promotes both of them, leading to NASH
Bibliographic Details
| Main Authors: |
Xinzhi Li,
Kaixin Ding,
Xueying Li,
Bingchuan Yuan,
Yuqin Wang,
Zhicheng Yao,
Shuaikang Wang,
He Huang,
Bolin Xu,
Liwei Xie,
Tuo Deng,
Xiao-wei Chen,
Zheng Chen |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-32163-w
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