Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH)
Ectopic lipid accumulation and inflammation are the essential signs of NASH. Here, the authors show that hepatic WTAP is a key integrative repressor of ectopic lipid accumulation and inflammation during NASH progression, and hepatic deletion of Wtap promotes both of them, leading to NASH
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32163-w |
| _version_ | 1828444402157092864 |
|---|---|
| author | Xinzhi Li Kaixin Ding Xueying Li Bingchuan Yuan Yuqin Wang Zhicheng Yao Shuaikang Wang He Huang Bolin Xu Liwei Xie Tuo Deng Xiao-wei Chen Zheng Chen |
| author_facet | Xinzhi Li Kaixin Ding Xueying Li Bingchuan Yuan Yuqin Wang Zhicheng Yao Shuaikang Wang He Huang Bolin Xu Liwei Xie Tuo Deng Xiao-wei Chen Zheng Chen |
| author_sort | Xinzhi Li |
| collection | DOAJ |
| description | Ectopic lipid accumulation and inflammation are the essential signs of NASH. Here, the authors show that hepatic WTAP is a key integrative repressor of ectopic lipid accumulation and inflammation during NASH progression, and hepatic deletion of Wtap promotes both of them, leading to NASH |
| first_indexed | 2024-12-10T21:43:52Z |
| format | Article |
| id | doaj.art-967c9453207440ac8b112043c8a2cc1a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T21:43:52Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-967c9453207440ac8b112043c8a2cc1a2022-12-22T01:32:26ZengNature PortfolioNature Communications2041-17232022-08-0113111910.1038/s41467-022-32163-wDeficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH)Xinzhi Li0Kaixin Ding1Xueying Li2Bingchuan Yuan3Yuqin Wang4Zhicheng Yao5Shuaikang Wang6He Huang7Bolin Xu8Liwei Xie9Tuo Deng10Xiao-wei Chen11Zheng Chen12HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of TechnologyHIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of TechnologyHIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of TechnologyHIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of TechnologyHIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of TechnologyDepartment of General Surgery, The Third Affiliated Hospital of Sun Yat-sen UniversityShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan UniversityShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan UniversityState Key Laboratory of Membrane Biology, Institute of Molecular Medicine, College of Future Technology, and Center for Life Sciences, Peking UniversityGuangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of SciencesNational Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South UniversityState Key Laboratory of Membrane Biology, Institute of Molecular Medicine, College of Future Technology, and Center for Life Sciences, Peking UniversityHIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of TechnologyEctopic lipid accumulation and inflammation are the essential signs of NASH. Here, the authors show that hepatic WTAP is a key integrative repressor of ectopic lipid accumulation and inflammation during NASH progression, and hepatic deletion of Wtap promotes both of them, leading to NASHhttps://doi.org/10.1038/s41467-022-32163-w |
| spellingShingle | Xinzhi Li Kaixin Ding Xueying Li Bingchuan Yuan Yuqin Wang Zhicheng Yao Shuaikang Wang He Huang Bolin Xu Liwei Xie Tuo Deng Xiao-wei Chen Zheng Chen Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH) Nature Communications |
| title | Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH) |
| title_full | Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH) |
| title_fullStr | Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH) |
| title_full_unstemmed | Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH) |
| title_short | Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH) |
| title_sort | deficiency of wtap in hepatocytes induces lipoatrophy and non alcoholic steatohepatitis nash |
| url | https://doi.org/10.1038/s41467-022-32163-w |
| work_keys_str_mv | AT xinzhili deficiencyofwtapinhepatocytesinduceslipoatrophyandnonalcoholicsteatohepatitisnash AT kaixinding deficiencyofwtapinhepatocytesinduceslipoatrophyandnonalcoholicsteatohepatitisnash AT xueyingli deficiencyofwtapinhepatocytesinduceslipoatrophyandnonalcoholicsteatohepatitisnash AT bingchuanyuan deficiencyofwtapinhepatocytesinduceslipoatrophyandnonalcoholicsteatohepatitisnash AT yuqinwang deficiencyofwtapinhepatocytesinduceslipoatrophyandnonalcoholicsteatohepatitisnash AT zhichengyao deficiencyofwtapinhepatocytesinduceslipoatrophyandnonalcoholicsteatohepatitisnash AT shuaikangwang deficiencyofwtapinhepatocytesinduceslipoatrophyandnonalcoholicsteatohepatitisnash AT hehuang deficiencyofwtapinhepatocytesinduceslipoatrophyandnonalcoholicsteatohepatitisnash AT bolinxu deficiencyofwtapinhepatocytesinduceslipoatrophyandnonalcoholicsteatohepatitisnash AT liweixie deficiencyofwtapinhepatocytesinduceslipoatrophyandnonalcoholicsteatohepatitisnash AT tuodeng deficiencyofwtapinhepatocytesinduceslipoatrophyandnonalcoholicsteatohepatitisnash AT xiaoweichen deficiencyofwtapinhepatocytesinduceslipoatrophyandnonalcoholicsteatohepatitisnash AT zhengchen deficiencyofwtapinhepatocytesinduceslipoatrophyandnonalcoholicsteatohepatitisnash |