Epidemiological characteristics of Epstein–Barr virus infection
Introduction. The Epstein–Barr virus (EBV) is one of the most common pathogens — it infects 90% of the world’s population. However, specific characteristics of the EBV infection epidemic process remain unidentified. The previous studies focusing on assessment of incidence rates for infectious mononu...
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| Format: | Article |
| Language: | Russian |
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Central Research Institute for Epidemiology
2022-01-01
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| Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
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| Online Access: | https://microbiol.elpub.ru/jour/article/view/1147 |
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| author | T. V. Solomay T. A. Semenenko A. V. Tutelyan M. V. Bobrova |
| author_facet | T. V. Solomay T. A. Semenenko A. V. Tutelyan M. V. Bobrova |
| author_sort | T. V. Solomay |
| collection | DOAJ |
| description | Introduction. The Epstein–Barr virus (EBV) is one of the most common pathogens — it infects 90% of the world’s population. However, specific characteristics of the EBV infection epidemic process remain unidentified. The previous studies focusing on assessment of incidence rates for infectious mononucleosis (IM) tend to ignore the serological status of the population.The aim of the study was to identify epidemiological characteristics and assess the prevalence of serological markers for EBV infection for further epidemic control measures development.Materials and methods. In Moscow, the thorough analysis was performed using the data on IM incidence (Form 2 "Data on Infectious and Parasitic Diseases") and test results for 138,232 people checked for presence of VCA IgG, EBNA IgG, VCA IgM, EA IgG, and EBV DNA in their blood and saliva in 2011–2020.Results. The periodic pattern of IM incidence was discovered, demonstrating the repetitive peaks every 9 to 11 years and a strong direct correlative relationship with detection rates for active EBV infection markers. The intra-annual dynamics of IM incidence is characterized by a seasonal upswing during cold seasons of the year, reaching its peaks in October, November, or February and associated with a marked decrease in the VCA IgG and EBNA IgG seroprevalence. Children within the 1 to 17-year age range are groups at risk for acquiring primary infection, demonstrating significantly lower detection rates for chronic EBV infection (VCA IgG and EBNA IgG) markers and higher rates for VCA IgM and EBV DNA markers in blood compared to adults. The contribution of adult population to the epidemic process is formed through reactivation of chronic infection, which is observed primarily among women.Conclusion. The identified characteristics are essential for comprehensive understanding of the EBV infection epidemic process and can be used for developing preventive and anti-epidemic measures. |
| first_indexed | 2024-12-10T19:08:11Z |
| format | Article |
| id | doaj.art-967ccb1cd6804795b201421cd2864132 |
| institution | Directory Open Access Journal |
| issn | 0372-9311 2686-7613 |
| language | Russian |
| last_indexed | 2024-12-10T19:08:11Z |
| publishDate | 2022-01-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Журнал микробиологии, эпидемиологии и иммунобиологии |
| spelling | doaj.art-967ccb1cd6804795b201421cd28641322022-12-22T01:36:51ZrusCentral Research Institute for EpidemiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-76132022-01-0198668569610.36233/0372-9311-139781Epidemiological characteristics of Epstein–Barr virus infectionT. V. Solomay0T. A. Semenenko1A. V. Tutelyan2M. V. Bobrova3Interregional Department No. 1 of the FMBA of Russia; I.I. Mechnikov Research Institute of Vaccines and SeraNational Research Center of Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya; I.M. Sechenov First Moscow State Medical University (Sechenov University)Central Research Institute of EpidemiologySemashko National Research Institute of Public HealthIntroduction. The Epstein–Barr virus (EBV) is one of the most common pathogens — it infects 90% of the world’s population. However, specific characteristics of the EBV infection epidemic process remain unidentified. The previous studies focusing on assessment of incidence rates for infectious mononucleosis (IM) tend to ignore the serological status of the population.The aim of the study was to identify epidemiological characteristics and assess the prevalence of serological markers for EBV infection for further epidemic control measures development.Materials and methods. In Moscow, the thorough analysis was performed using the data on IM incidence (Form 2 "Data on Infectious and Parasitic Diseases") and test results for 138,232 people checked for presence of VCA IgG, EBNA IgG, VCA IgM, EA IgG, and EBV DNA in their blood and saliva in 2011–2020.Results. The periodic pattern of IM incidence was discovered, demonstrating the repetitive peaks every 9 to 11 years and a strong direct correlative relationship with detection rates for active EBV infection markers. The intra-annual dynamics of IM incidence is characterized by a seasonal upswing during cold seasons of the year, reaching its peaks in October, November, or February and associated with a marked decrease in the VCA IgG and EBNA IgG seroprevalence. Children within the 1 to 17-year age range are groups at risk for acquiring primary infection, demonstrating significantly lower detection rates for chronic EBV infection (VCA IgG and EBNA IgG) markers and higher rates for VCA IgM and EBV DNA markers in blood compared to adults. The contribution of adult population to the epidemic process is formed through reactivation of chronic infection, which is observed primarily among women.Conclusion. The identified characteristics are essential for comprehensive understanding of the EBV infection epidemic process and can be used for developing preventive and anti-epidemic measures.https://microbiol.elpub.ru/jour/article/view/1147epstein–barr virusinfectious mononucleosisseroprevalenceincidenceepidemiological characteristics |
| spellingShingle | T. V. Solomay T. A. Semenenko A. V. Tutelyan M. V. Bobrova Epidemiological characteristics of Epstein–Barr virus infection Журнал микробиологии, эпидемиологии и иммунобиологии epstein–barr virus infectious mononucleosis seroprevalence incidence epidemiological characteristics |
| title | Epidemiological characteristics of Epstein–Barr virus infection |
| title_full | Epidemiological characteristics of Epstein–Barr virus infection |
| title_fullStr | Epidemiological characteristics of Epstein–Barr virus infection |
| title_full_unstemmed | Epidemiological characteristics of Epstein–Barr virus infection |
| title_short | Epidemiological characteristics of Epstein–Barr virus infection |
| title_sort | epidemiological characteristics of epstein barr virus infection |
| topic | epstein–barr virus infectious mononucleosis seroprevalence incidence epidemiological characteristics |
| url | https://microbiol.elpub.ru/jour/article/view/1147 |
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