NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America
An imipenem-resistant Enterobacter cloacae isolate was recovered from the blood of a patient with a hematologic malignancy. Analytical isoelectric focusing, inhibitor studies, hydrolysis, induction assays, and molecular sequencing methods confirmed the presence of a NmcA carbapenem-hydrolyzing enzym...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2003-08-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/9/8/03-0096_article |
| _version_ | 1819148333560627200 |
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| author | Sudha Pottumarthy Ellen Smith Moland Stefan Juretschko Susan R. Swanzy Kenneth S. Thomson Thomas R. Fritsche |
| author_facet | Sudha Pottumarthy Ellen Smith Moland Stefan Juretschko Susan R. Swanzy Kenneth S. Thomson Thomas R. Fritsche |
| author_sort | Sudha Pottumarthy |
| collection | DOAJ |
| description | An imipenem-resistant Enterobacter cloacae isolate was recovered from the blood of a patient with a hematologic malignancy. Analytical isoelectric focusing, inhibitor studies, hydrolysis, induction assays, and molecular sequencing methods confirmed the presence of a NmcA carbapenem-hydrolyzing enzyme. This first report of NmcA detected in North America warrants further investigation into its distribution and clinical impact. |
| first_indexed | 2024-12-22T13:44:03Z |
| format | Article |
| id | doaj.art-967cce27e7534137b35ec41aa00b071e |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-22T13:44:03Z |
| publishDate | 2003-08-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-967cce27e7534137b35ec41aa00b071e2022-12-21T18:23:50ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592003-08-0198999100210.3201/eid0908.030096NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North AmericaSudha PottumarthyEllen Smith MolandStefan JuretschkoSusan R. SwanzyKenneth S. ThomsonThomas R. FritscheAn imipenem-resistant Enterobacter cloacae isolate was recovered from the blood of a patient with a hematologic malignancy. Analytical isoelectric focusing, inhibitor studies, hydrolysis, induction assays, and molecular sequencing methods confirmed the presence of a NmcA carbapenem-hydrolyzing enzyme. This first report of NmcA detected in North America warrants further investigation into its distribution and clinical impact.https://wwwnc.cdc.gov/eid/article/9/8/03-0096_articleAntibiotic resistancebeta-lactamasecarbapenemdispatchEnterobacter cloacaeUnited States |
| spellingShingle | Sudha Pottumarthy Ellen Smith Moland Stefan Juretschko Susan R. Swanzy Kenneth S. Thomson Thomas R. Fritsche NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America Emerging Infectious Diseases Antibiotic resistance beta-lactamase carbapenem dispatch Enterobacter cloacae United States |
| title | NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America |
| title_full | NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America |
| title_fullStr | NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America |
| title_full_unstemmed | NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America |
| title_short | NmcA Carbapenem-hydrolyzing Enzyme in Enterobacter cloacae in North America |
| title_sort | nmca carbapenem hydrolyzing enzyme in enterobacter cloacae in north america |
| topic | Antibiotic resistance beta-lactamase carbapenem dispatch Enterobacter cloacae United States |
| url | https://wwwnc.cdc.gov/eid/article/9/8/03-0096_article |
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