Chemotherapy-Mediated Neuronal Aberration
Chemotherapy is a life-sustaining therapeutic option for cancer patients. Despite the advancement of several modern therapies, such as immunotherapy, gene therapy, etc., chemotherapy remains the first-line therapy for most cancer patients. Along with its anti-cancerous effect, chemotherapy exhibits...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/8/1165 |
| _version_ | 1827728924936765440 |
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| author | Pradip Kumar Jaiswara Surendra Kumar Shukla |
| author_facet | Pradip Kumar Jaiswara Surendra Kumar Shukla |
| author_sort | Pradip Kumar Jaiswara |
| collection | DOAJ |
| description | Chemotherapy is a life-sustaining therapeutic option for cancer patients. Despite the advancement of several modern therapies, such as immunotherapy, gene therapy, etc., chemotherapy remains the first-line therapy for most cancer patients. Along with its anti-cancerous effect, chemotherapy exhibits several detrimental consequences that restrict its efficacy and long-term utilization. Moreover, it effectively hampers the quality of life of cancer patients. Cancer patients receiving chemotherapeutic drugs suffer from neurological dysfunction, referred to as chemobrain, that includes cognitive and memory dysfunction and deficits in learning, reasoning, and concentration ability. Chemotherapy exhibits neurotoxicity by damaging the DNA in neurons by interfering with the DNA repair system and antioxidant machinery. In addition, chemotherapy also provokes inflammation by inducing the release of various pro-inflammatory cytokines, including NF-kB, IL-1β, IL-6, and TNF-α. The chemotherapy-mediated inflammation contributes to chemobrain in cancer patients. These inflammatory cytokines modulate several growth signaling pathways and reactive oxygen species homeostasis leading to systemic inflammation in the body. This review is an effort to summarize the available information which discusses the role of chemotherapy-induced inflammation in chemobrain and how it impacts different aspects of therapeutic outcome and the overall quality of life of the patient. Further, this article also discusses the potential of herbal-based remedies to overcome chemotherapy-mediated neuronal toxicity as well as to improve the quality of life of cancer patients. |
| first_indexed | 2024-03-10T23:39:44Z |
| format | Article |
| id | doaj.art-967f715b01cd476da0f7fb35f855591f |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T23:39:44Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-967f715b01cd476da0f7fb35f855591f2023-11-19T02:35:00ZengMDPI AGPharmaceuticals1424-82472023-08-01168116510.3390/ph16081165Chemotherapy-Mediated Neuronal AberrationPradip Kumar Jaiswara0Surendra Kumar Shukla1Department of Oncology Science, University of Oklahoma Health Science Centre, Oklahoma City, OK 73104, USADepartment of Oncology Science, University of Oklahoma Health Science Centre, Oklahoma City, OK 73104, USAChemotherapy is a life-sustaining therapeutic option for cancer patients. Despite the advancement of several modern therapies, such as immunotherapy, gene therapy, etc., chemotherapy remains the first-line therapy for most cancer patients. Along with its anti-cancerous effect, chemotherapy exhibits several detrimental consequences that restrict its efficacy and long-term utilization. Moreover, it effectively hampers the quality of life of cancer patients. Cancer patients receiving chemotherapeutic drugs suffer from neurological dysfunction, referred to as chemobrain, that includes cognitive and memory dysfunction and deficits in learning, reasoning, and concentration ability. Chemotherapy exhibits neurotoxicity by damaging the DNA in neurons by interfering with the DNA repair system and antioxidant machinery. In addition, chemotherapy also provokes inflammation by inducing the release of various pro-inflammatory cytokines, including NF-kB, IL-1β, IL-6, and TNF-α. The chemotherapy-mediated inflammation contributes to chemobrain in cancer patients. These inflammatory cytokines modulate several growth signaling pathways and reactive oxygen species homeostasis leading to systemic inflammation in the body. This review is an effort to summarize the available information which discusses the role of chemotherapy-induced inflammation in chemobrain and how it impacts different aspects of therapeutic outcome and the overall quality of life of the patient. Further, this article also discusses the potential of herbal-based remedies to overcome chemotherapy-mediated neuronal toxicity as well as to improve the quality of life of cancer patients.https://www.mdpi.com/1424-8247/16/8/1165chemotherapyinflammationcytokinesneuronal aberrationtoxicity |
| spellingShingle | Pradip Kumar Jaiswara Surendra Kumar Shukla Chemotherapy-Mediated Neuronal Aberration Pharmaceuticals chemotherapy inflammation cytokines neuronal aberration toxicity |
| title | Chemotherapy-Mediated Neuronal Aberration |
| title_full | Chemotherapy-Mediated Neuronal Aberration |
| title_fullStr | Chemotherapy-Mediated Neuronal Aberration |
| title_full_unstemmed | Chemotherapy-Mediated Neuronal Aberration |
| title_short | Chemotherapy-Mediated Neuronal Aberration |
| title_sort | chemotherapy mediated neuronal aberration |
| topic | chemotherapy inflammation cytokines neuronal aberration toxicity |
| url | https://www.mdpi.com/1424-8247/16/8/1165 |
| work_keys_str_mv | AT pradipkumarjaiswara chemotherapymediatedneuronalaberration AT surendrakumarshukla chemotherapymediatedneuronalaberration |