Toxicity of azathioprine: why and when? analysis of the prevalence of polymorphism in Joinville, SC, Brazil
CONTEXT: The use of thiopurine drugs such as azathioprine and 6-mercaptopurine has become quite common in the treatment of inflammatory bowel disease, transplantation and acute leukemias. Despite their effectiveness, these drugs are capable of causing drug-induced toxicity with the risk of death by...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)
2012-06-01
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| Series: | Arquivos de Gastroenterologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032012000200007&lng=en&tlng=en |
| _version_ | 1818988174910685184 |
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| author | Gabriela Roncone Gastal Simone Moreira Caroline Furtado Noble Leslie Ecker Ferreira Paulo Henrique Condeixa de França Mauro Pinho |
| author_facet | Gabriela Roncone Gastal Simone Moreira Caroline Furtado Noble Leslie Ecker Ferreira Paulo Henrique Condeixa de França Mauro Pinho |
| author_sort | Gabriela Roncone Gastal |
| collection | DOAJ |
| description | CONTEXT: The use of thiopurine drugs such as azathioprine and 6-mercaptopurine has become quite common in the treatment of inflammatory bowel disease, transplantation and acute leukemias. Despite their effectiveness, these drugs are capable of causing drug-induced toxicity with the risk of death by myelosuppression. It is now known that these complications occur because of genetic polymorphisms of the thiopurinemethyltransferase (TPMT) enzyme, responsible for its metabolism. OBJECTIVE: To assess the prevalence of thiopurine methyltransferase polymorphisms in the population of Joinville, SC, Brazil. METHODS: We analyzed the frequency of four main allelic variants of the TPMT gene in 199 blood donors from Joinville, from February to April 2010. RESULTS: The normal allele ("wild-type") was found in 93.9% of subjects studied. TPMT variants were detected in 12 subjects (6.03%). CONCLUSIONS: From this study, it was estimated at 6% the risk of toxicity by the administration of azathioprine and 6-mercaptopurine to patients in Joinville. |
| first_indexed | 2024-12-20T19:18:24Z |
| format | Article |
| id | doaj.art-967f7472ec8d4aec9f7b921ecfedccdc |
| institution | Directory Open Access Journal |
| issn | 1678-4219 |
| language | English |
| last_indexed | 2024-12-20T19:18:24Z |
| publishDate | 2012-06-01 |
| publisher | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) |
| record_format | Article |
| series | Arquivos de Gastroenterologia |
| spelling | doaj.art-967f7472ec8d4aec9f7b921ecfedccdc2022-12-21T19:29:03ZengInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)Arquivos de Gastroenterologia1678-42192012-06-0149213013410.1590/S0004-28032012000200007S0004-28032012000200007Toxicity of azathioprine: why and when? analysis of the prevalence of polymorphism in Joinville, SC, BrazilGabriela Roncone Gastal0Simone Moreira1Caroline Furtado Noble2Leslie Ecker Ferreira3Paulo Henrique Condeixa de França4Mauro Pinho5Department of HematologyDepartment of HematologyUniversidade da Região de JoinvilleUniversidade da Região de JoinvilleUniversidade da Região de JoinvilleUniversidade da Região de JoinvilleCONTEXT: The use of thiopurine drugs such as azathioprine and 6-mercaptopurine has become quite common in the treatment of inflammatory bowel disease, transplantation and acute leukemias. Despite their effectiveness, these drugs are capable of causing drug-induced toxicity with the risk of death by myelosuppression. It is now known that these complications occur because of genetic polymorphisms of the thiopurinemethyltransferase (TPMT) enzyme, responsible for its metabolism. OBJECTIVE: To assess the prevalence of thiopurine methyltransferase polymorphisms in the population of Joinville, SC, Brazil. METHODS: We analyzed the frequency of four main allelic variants of the TPMT gene in 199 blood donors from Joinville, from February to April 2010. RESULTS: The normal allele ("wild-type") was found in 93.9% of subjects studied. TPMT variants were detected in 12 subjects (6.03%). CONCLUSIONS: From this study, it was estimated at 6% the risk of toxicity by the administration of azathioprine and 6-mercaptopurine to patients in Joinville.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032012000200007&lng=en&tlng=enAzatioprinatoxicidade6-mercaptopurinatoxicidadeDoenças inflamatórias intestinaisPolimorfismo genético |
| spellingShingle | Gabriela Roncone Gastal Simone Moreira Caroline Furtado Noble Leslie Ecker Ferreira Paulo Henrique Condeixa de França Mauro Pinho Toxicity of azathioprine: why and when? analysis of the prevalence of polymorphism in Joinville, SC, Brazil Arquivos de Gastroenterologia Azatioprina toxicidade 6-mercaptopurina toxicidade Doenças inflamatórias intestinais Polimorfismo genético |
| title | Toxicity of azathioprine: why and when? analysis of the prevalence of polymorphism in Joinville, SC, Brazil |
| title_full | Toxicity of azathioprine: why and when? analysis of the prevalence of polymorphism in Joinville, SC, Brazil |
| title_fullStr | Toxicity of azathioprine: why and when? analysis of the prevalence of polymorphism in Joinville, SC, Brazil |
| title_full_unstemmed | Toxicity of azathioprine: why and when? analysis of the prevalence of polymorphism in Joinville, SC, Brazil |
| title_short | Toxicity of azathioprine: why and when? analysis of the prevalence of polymorphism in Joinville, SC, Brazil |
| title_sort | toxicity of azathioprine why and when analysis of the prevalence of polymorphism in joinville sc brazil |
| topic | Azatioprina toxicidade 6-mercaptopurina toxicidade Doenças inflamatórias intestinais Polimorfismo genético |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032012000200007&lng=en&tlng=en |
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