Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations.
The experience of auditory verbal hallucinations (AVH, "hearing voices") in schizophrenia has been found to be associated with reduced auditory cortex activation during perception of real auditory stimuli like tones and speech. We re-examined this finding using 46 patients with schizophren...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0276975 |
| _version_ | 1797956117734621184 |
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| author | Joan Soler-Vidal Paola Fuentes-Claramonte Pilar Salgado-Pineda Nuria Ramiro María Ángeles García-León María Llanos Torres Antonio Arévalo Amalia Guerrero-Pedraza Josep Munuera Salvador Sarró Raymond Salvador Wolfram Hinzen Peter McKenna Edith Pomarol-Clotet |
| author_facet | Joan Soler-Vidal Paola Fuentes-Claramonte Pilar Salgado-Pineda Nuria Ramiro María Ángeles García-León María Llanos Torres Antonio Arévalo Amalia Guerrero-Pedraza Josep Munuera Salvador Sarró Raymond Salvador Wolfram Hinzen Peter McKenna Edith Pomarol-Clotet |
| author_sort | Joan Soler-Vidal |
| collection | DOAJ |
| description | The experience of auditory verbal hallucinations (AVH, "hearing voices") in schizophrenia has been found to be associated with reduced auditory cortex activation during perception of real auditory stimuli like tones and speech. We re-examined this finding using 46 patients with schizophrenia (23 with frequent AVH and 23 hallucination-free), who underwent fMRI scanning while they heard words, sentences and reversed speech. Twenty-five matched healthy controls were also examined. Perception of words, sentences and reversed speech all elicited activation of the bilateral superior temporal cortex, the inferior and lateral prefrontal cortex, the inferior parietal cortex and the supplementary motor area in the patients and the healthy controls. During the sentence and reversed speech conditions, the schizophrenia patients as a group showed reduced activation in the left primary auditory cortex (Heschl's gyrus) relative to the healthy controls. No differences were found between the patients with and without hallucinations in any condition. This study therefore fails to support previous findings that experience of AVH attenuates speech-perception-related brain activations in the auditory cortex. At the same time, it suggests that schizophrenia patients, regardless of presence of AVH, show reduced activation in the primary auditory cortex during speech perception, a finding which could reflect an early information processing deficit in the disorder. |
| first_indexed | 2024-04-10T23:44:55Z |
| format | Article |
| id | doaj.art-96806fc63eec4f9c9e178720973120a4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T23:44:55Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-96806fc63eec4f9c9e178720973120a42023-01-11T05:31:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011712e027697510.1371/journal.pone.0276975Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations.Joan Soler-VidalPaola Fuentes-ClaramontePilar Salgado-PinedaNuria RamiroMaría Ángeles García-LeónMaría Llanos TorresAntonio ArévaloAmalia Guerrero-PedrazaJosep MunueraSalvador SarróRaymond SalvadorWolfram HinzenPeter McKennaEdith Pomarol-ClotetThe experience of auditory verbal hallucinations (AVH, "hearing voices") in schizophrenia has been found to be associated with reduced auditory cortex activation during perception of real auditory stimuli like tones and speech. We re-examined this finding using 46 patients with schizophrenia (23 with frequent AVH and 23 hallucination-free), who underwent fMRI scanning while they heard words, sentences and reversed speech. Twenty-five matched healthy controls were also examined. Perception of words, sentences and reversed speech all elicited activation of the bilateral superior temporal cortex, the inferior and lateral prefrontal cortex, the inferior parietal cortex and the supplementary motor area in the patients and the healthy controls. During the sentence and reversed speech conditions, the schizophrenia patients as a group showed reduced activation in the left primary auditory cortex (Heschl's gyrus) relative to the healthy controls. No differences were found between the patients with and without hallucinations in any condition. This study therefore fails to support previous findings that experience of AVH attenuates speech-perception-related brain activations in the auditory cortex. At the same time, it suggests that schizophrenia patients, regardless of presence of AVH, show reduced activation in the primary auditory cortex during speech perception, a finding which could reflect an early information processing deficit in the disorder.https://doi.org/10.1371/journal.pone.0276975 |
| spellingShingle | Joan Soler-Vidal Paola Fuentes-Claramonte Pilar Salgado-Pineda Nuria Ramiro María Ángeles García-León María Llanos Torres Antonio Arévalo Amalia Guerrero-Pedraza Josep Munuera Salvador Sarró Raymond Salvador Wolfram Hinzen Peter McKenna Edith Pomarol-Clotet Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations. PLoS ONE |
| title | Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations. |
| title_full | Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations. |
| title_fullStr | Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations. |
| title_full_unstemmed | Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations. |
| title_short | Brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations. |
| title_sort | brain correlates of speech perception in schizophrenia patients with and without auditory hallucinations |
| url | https://doi.org/10.1371/journal.pone.0276975 |
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