Clinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease: a pilot study in patients undergoing supportive periodontal therapy
Abstract Objective This study aimed to evaluate clinically the effect of a novel dentifrice containing three kinds of bactericidal ingredients on periodontal disease. Results This was a single-arm, prospective clinical study that enrolled patients with periodontitis undergoing supportive periodontal...
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BMC
2018-02-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-018-3216-x |
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| author | Daichi Kita Takashi Kinumatsu Atsushi Yokomizo Miki Tanaka Masahiro Egawa Asako Makino-Oi Sachiyo Tomita Atsushi Saito |
| author_facet | Daichi Kita Takashi Kinumatsu Atsushi Yokomizo Miki Tanaka Masahiro Egawa Asako Makino-Oi Sachiyo Tomita Atsushi Saito |
| author_sort | Daichi Kita |
| collection | DOAJ |
| description | Abstract Objective This study aimed to evaluate clinically the effect of a novel dentifrice containing three kinds of bactericidal ingredients on periodontal disease. Results This was a single-arm, prospective clinical study that enrolled patients with periodontitis undergoing supportive periodontal therapy. Periodontal examination, microbiological testing of saliva samples, and evaluation of inflammatory markers (IL-1β, IL-6, IL-8, TNF-α) in gingival crevicular fluid were performed. After 4 weeks of the use of test dentifrice, these parameters were re-evaluated. The use of dentifrice was also subjectively evaluated by clinicians and participants. Among 30 participants, there were significant improvements in the periodontal and microbiological parameters, and the level of interleukin-1β in the gingival crevicular fluid, following the use of the test dentifrice. In clinicians’ subjective evaluation of the overall usefulness of the dentifrice, ‘mild’ and ‘moderate’ improvement accounted for 83% of the total responses. In the participants’ subjective evaluation, the majority indicated their experience of the use as favorable. Within the limitations of this study, it is suggested that the progression of periodontal disease during the supportive periodontal therapy can be prevented by the use of the test dentifrice. Trial registration UMIN Clinical Trials Registry (UMIN-CTR) 000023175. Date of formal registration: July 14, 2016 (https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000026716) |
| first_indexed | 2024-12-10T23:46:18Z |
| format | Article |
| id | doaj.art-9682a39832074d46a5413fb485cee621 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-10T23:46:18Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-9682a39832074d46a5413fb485cee6212022-12-22T01:28:55ZengBMCBMC Research Notes1756-05002018-02-011111610.1186/s13104-018-3216-xClinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease: a pilot study in patients undergoing supportive periodontal therapyDaichi Kita0Takashi Kinumatsu1Atsushi Yokomizo2Miki Tanaka3Masahiro Egawa4Asako Makino-Oi5Sachiyo Tomita6Atsushi Saito7Department of Periodontology, Tokyo Dental CollegeDepartment of Periodontology, Tokyo Dental CollegeDaiichi Sankyo Healthcare Co., Ltd.Daiichi Sankyo Healthcare Co., Ltd.Department of Periodontology, Tokyo Dental CollegeDepartment of Periodontology, Tokyo Dental CollegeDepartment of Periodontology, Tokyo Dental CollegeDepartment of Periodontology, Tokyo Dental CollegeAbstract Objective This study aimed to evaluate clinically the effect of a novel dentifrice containing three kinds of bactericidal ingredients on periodontal disease. Results This was a single-arm, prospective clinical study that enrolled patients with periodontitis undergoing supportive periodontal therapy. Periodontal examination, microbiological testing of saliva samples, and evaluation of inflammatory markers (IL-1β, IL-6, IL-8, TNF-α) in gingival crevicular fluid were performed. After 4 weeks of the use of test dentifrice, these parameters were re-evaluated. The use of dentifrice was also subjectively evaluated by clinicians and participants. Among 30 participants, there were significant improvements in the periodontal and microbiological parameters, and the level of interleukin-1β in the gingival crevicular fluid, following the use of the test dentifrice. In clinicians’ subjective evaluation of the overall usefulness of the dentifrice, ‘mild’ and ‘moderate’ improvement accounted for 83% of the total responses. In the participants’ subjective evaluation, the majority indicated their experience of the use as favorable. Within the limitations of this study, it is suggested that the progression of periodontal disease during the supportive periodontal therapy can be prevented by the use of the test dentifrice. Trial registration UMIN Clinical Trials Registry (UMIN-CTR) 000023175. Date of formal registration: July 14, 2016 (https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000026716)http://link.springer.com/article/10.1186/s13104-018-3216-xPeriodontal diseaseSupportive periodontal therapyDentifriceBactericidal ingredients |
| spellingShingle | Daichi Kita Takashi Kinumatsu Atsushi Yokomizo Miki Tanaka Masahiro Egawa Asako Makino-Oi Sachiyo Tomita Atsushi Saito Clinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease: a pilot study in patients undergoing supportive periodontal therapy BMC Research Notes Periodontal disease Supportive periodontal therapy Dentifrice Bactericidal ingredients |
| title | Clinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease: a pilot study in patients undergoing supportive periodontal therapy |
| title_full | Clinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease: a pilot study in patients undergoing supportive periodontal therapy |
| title_fullStr | Clinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease: a pilot study in patients undergoing supportive periodontal therapy |
| title_full_unstemmed | Clinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease: a pilot study in patients undergoing supportive periodontal therapy |
| title_short | Clinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease: a pilot study in patients undergoing supportive periodontal therapy |
| title_sort | clinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease a pilot study in patients undergoing supportive periodontal therapy |
| topic | Periodontal disease Supportive periodontal therapy Dentifrice Bactericidal ingredients |
| url | http://link.springer.com/article/10.1186/s13104-018-3216-x |
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