Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments
Purpose Magnetic resonance guided focused ultrasound (MRgFUS) treatment of tumors uses inter-sonication delays to allow heat to dissipate from the skin and other near-field tissues. Despite inter-sonication delays, treatment of tumors close to the skin risks skin burns. This work has designed and ev...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/02656736.2021.1914872 |
| _version_ | 1819319833244729344 |
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| author | Robb Merrill Henrik Odéen Christopher Dillon Rachelle Bitton Pejman Ghanouni Allison Payne |
| author_facet | Robb Merrill Henrik Odéen Christopher Dillon Rachelle Bitton Pejman Ghanouni Allison Payne |
| author_sort | Robb Merrill |
| collection | DOAJ |
| description | Purpose Magnetic resonance guided focused ultrasound (MRgFUS) treatment of tumors uses inter-sonication delays to allow heat to dissipate from the skin and other near-field tissues. Despite inter-sonication delays, treatment of tumors close to the skin risks skin burns. This work has designed and evaluated an open-source, conformable, skin-cooling system for body MRgFUS treatments to reduce skin burns and enable ablation closer to the skin. Methods A MR-compatible skin cooling system is described that features a conformable skin-cooling pad assembly with feedback control allowing continuous flow and pressure maintenance during the procedure. System performance was evaluated with hydrophone, phantom and in vivo porcine studies. Sonications were performed 10 and 5 mm from the skin surface under both control and forced convective skin-cooling conditions. 3D MR temperature imaging was acquired in real time and the accumulated thermal dose volume was measured. Gross analysis of the skin post-sonication was further performed. Device conformability was demonstrated at several body locations. Results Hydrophone studies demonstrated no beam aberration, but a 5–12% reduction of the peak pressure due to the presence of the skin-cooling pad assembly in the acoustic near field. Phantom evaluation demonstrated there is no MR temperature imaging precision reduction or any other artifacts present due to the coolant flow during MRgFUS sonication. The porcine studies demonstrated skin burns were reduced in size or eliminated when compared to the control condition. Conclusion An open-source design of an MRgFUS active skin cooling system demonstrates device conformability with a reduction of skin burns while ablating superficial tissues. |
| first_indexed | 2024-12-24T11:09:58Z |
| format | Article |
| id | doaj.art-9684d1063f1846f2b5f29894a80e1936 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-12-24T11:09:58Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-9684d1063f1846f2b5f29894a80e19362022-12-21T16:58:32ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572021-01-0138167969010.1080/02656736.2021.19148721914872Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatmentsRobb Merrill0Henrik Odéen1Christopher Dillon2Rachelle Bitton3Pejman Ghanouni4Allison Payne5Department of Radiology and Imaging Sciences, University of UtahDepartment of Radiology and Imaging Sciences, University of UtahSandia National LaboratoriesDepartment of Radiology, Stanford UniversityDepartment of Radiology, Stanford UniversityDepartment of Radiology and Imaging Sciences, University of UtahPurpose Magnetic resonance guided focused ultrasound (MRgFUS) treatment of tumors uses inter-sonication delays to allow heat to dissipate from the skin and other near-field tissues. Despite inter-sonication delays, treatment of tumors close to the skin risks skin burns. This work has designed and evaluated an open-source, conformable, skin-cooling system for body MRgFUS treatments to reduce skin burns and enable ablation closer to the skin. Methods A MR-compatible skin cooling system is described that features a conformable skin-cooling pad assembly with feedback control allowing continuous flow and pressure maintenance during the procedure. System performance was evaluated with hydrophone, phantom and in vivo porcine studies. Sonications were performed 10 and 5 mm from the skin surface under both control and forced convective skin-cooling conditions. 3D MR temperature imaging was acquired in real time and the accumulated thermal dose volume was measured. Gross analysis of the skin post-sonication was further performed. Device conformability was demonstrated at several body locations. Results Hydrophone studies demonstrated no beam aberration, but a 5–12% reduction of the peak pressure due to the presence of the skin-cooling pad assembly in the acoustic near field. Phantom evaluation demonstrated there is no MR temperature imaging precision reduction or any other artifacts present due to the coolant flow during MRgFUS sonication. The porcine studies demonstrated skin burns were reduced in size or eliminated when compared to the control condition. Conclusion An open-source design of an MRgFUS active skin cooling system demonstrates device conformability with a reduction of skin burns while ablating superficial tissues.http://dx.doi.org/10.1080/02656736.2021.1914872mrgfushifuskin burnsfocused ultrasoundskin cooling |
| spellingShingle | Robb Merrill Henrik Odéen Christopher Dillon Rachelle Bitton Pejman Ghanouni Allison Payne Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments International Journal of Hyperthermia mrgfus hifu skin burns focused ultrasound skin cooling |
| title | Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments |
| title_full | Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments |
| title_fullStr | Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments |
| title_full_unstemmed | Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments |
| title_short | Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments |
| title_sort | design and evaluation of an open source conformable skin cooling system for body magnetic resonance guided focused ultrasound treatments |
| topic | mrgfus hifu skin burns focused ultrasound skin cooling |
| url | http://dx.doi.org/10.1080/02656736.2021.1914872 |
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