Changes in lung function in adolescents with substance use disorders: an exploratory study
ABSTRACT Objective: To compare lung function between adolescents with and without substance use disorder (SUD). Methods: This was an observational, cross-sectional exploratory study. The sample consisted of 16 adolescents with SUD and 24 age-matched healthy controls. The adolescents in the clinica...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Pneumologia e Tisiologia
2023-11-01
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| Series: | Jornal Brasileiro de Pneumologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132023000500205&tlng=en |
| _version_ | 1797542686579752960 |
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| author | Daniela Benvenutti Kaiber João Henrique Chrusciel Maiara Martins Bernardo Mattos Miguel Gomes Luis Eduardo Wearick-Silva Márcio Vinícius Fagundes Donadio Frederico Friedrich Marcus Herbert Jones Thiago Wendt Viola |
| author_facet | Daniela Benvenutti Kaiber João Henrique Chrusciel Maiara Martins Bernardo Mattos Miguel Gomes Luis Eduardo Wearick-Silva Márcio Vinícius Fagundes Donadio Frederico Friedrich Marcus Herbert Jones Thiago Wendt Viola |
| author_sort | Daniela Benvenutti Kaiber |
| collection | DOAJ |
| description | ABSTRACT Objective: To compare lung function between adolescents with and without substance use disorder (SUD). Methods: This was an observational, cross-sectional exploratory study. The sample consisted of 16 adolescents with SUD and 24 age-matched healthy controls. The adolescents in the clinical group were recruited from a psychiatric inpatient unit for detoxification and rehabilitation; their primary diagnosis was SUD related to marijuana, cocaine, or polysubstance use. Questionnaires and pulmonary function tests were applied for clinical evaluation. Results: We found that FVC, FEV1, and their percentages of the predicted values were significantly lower in the adolescents with SUD than in those without. Those differences remained significant after adjustment for BMI and the effects of high levels of physical activity. The largest effect size (Cohen’s d = 1.82) was found for FVC as a percentage of the predicted value (FVC%), which was, on average, 17.95% lower in the SUD group. In addition, the years of regular use of smoked substances (tobacco, marijuana, and crack cocaine) correlated negatively with the FVC%. Conclusions: This exploratory study is innovative in that it demonstrates the early consequences of smoked substance use for the lung health of adolescents with SUD. |
| first_indexed | 2024-03-10T13:34:05Z |
| format | Article |
| id | doaj.art-968a5f91f4a948c59f3ec8fc68a17ea6 |
| institution | Directory Open Access Journal |
| issn | 1806-3756 |
| language | English |
| last_indexed | 2024-03-10T13:34:05Z |
| publishDate | 2023-11-01 |
| publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
| record_format | Article |
| series | Jornal Brasileiro de Pneumologia |
| spelling | doaj.art-968a5f91f4a948c59f3ec8fc68a17ea62023-11-21T07:42:54ZengSociedade Brasileira de Pneumologia e TisiologiaJornal Brasileiro de Pneumologia1806-37562023-11-0149510.36416/1806-3756/e20230274Changes in lung function in adolescents with substance use disorders: an exploratory studyDaniela Benvenutti Kaiberhttps://orcid.org/0009-0003-2648-228XJoão Henrique Chruscielhttps://orcid.org/0000-0003-3928-0831Maiara Martinshttps://orcid.org/0000-0003-0544-1211Bernardo Mattoshttps://orcid.org/0000-0002-1068-1992Miguel Gomeshttps://orcid.org/0009-0003-6130-1181Luis Eduardo Wearick-Silvahttps://orcid.org/0000-0002-8028-495XMárcio Vinícius Fagundes Donadiohttps://orcid.org/0000-0001-8836-9109Frederico Friedrichhttps://orcid.org/0000-0001-6939-0340Marcus Herbert Joneshttps://orcid.org/0000-0002-8263-1265Thiago Wendt Violahttps://orcid.org/0000-0001-5446-1695ABSTRACT Objective: To compare lung function between adolescents with and without substance use disorder (SUD). Methods: This was an observational, cross-sectional exploratory study. The sample consisted of 16 adolescents with SUD and 24 age-matched healthy controls. The adolescents in the clinical group were recruited from a psychiatric inpatient unit for detoxification and rehabilitation; their primary diagnosis was SUD related to marijuana, cocaine, or polysubstance use. Questionnaires and pulmonary function tests were applied for clinical evaluation. Results: We found that FVC, FEV1, and their percentages of the predicted values were significantly lower in the adolescents with SUD than in those without. Those differences remained significant after adjustment for BMI and the effects of high levels of physical activity. The largest effect size (Cohen’s d = 1.82) was found for FVC as a percentage of the predicted value (FVC%), which was, on average, 17.95% lower in the SUD group. In addition, the years of regular use of smoked substances (tobacco, marijuana, and crack cocaine) correlated negatively with the FVC%. Conclusions: This exploratory study is innovative in that it demonstrates the early consequences of smoked substance use for the lung health of adolescents with SUD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132023000500205&tlng=enAdolescentSubstance-related disordersLung/physiopathologyRespiratory tract diseases/etiologyCocaineCannabis |
| spellingShingle | Daniela Benvenutti Kaiber João Henrique Chrusciel Maiara Martins Bernardo Mattos Miguel Gomes Luis Eduardo Wearick-Silva Márcio Vinícius Fagundes Donadio Frederico Friedrich Marcus Herbert Jones Thiago Wendt Viola Changes in lung function in adolescents with substance use disorders: an exploratory study Jornal Brasileiro de Pneumologia Adolescent Substance-related disorders Lung/physiopathology Respiratory tract diseases/etiology Cocaine Cannabis |
| title | Changes in lung function in adolescents with substance use disorders: an exploratory study |
| title_full | Changes in lung function in adolescents with substance use disorders: an exploratory study |
| title_fullStr | Changes in lung function in adolescents with substance use disorders: an exploratory study |
| title_full_unstemmed | Changes in lung function in adolescents with substance use disorders: an exploratory study |
| title_short | Changes in lung function in adolescents with substance use disorders: an exploratory study |
| title_sort | changes in lung function in adolescents with substance use disorders an exploratory study |
| topic | Adolescent Substance-related disorders Lung/physiopathology Respiratory tract diseases/etiology Cocaine Cannabis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132023000500205&tlng=en |
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