FEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION
Аbstract. We have performed an analysis of associations between allelic polymorphisms of heat shock protein (HSP) genes, i.e., HSP70-2 1267А→G and HSP70-НОМ 2437Т→С in Caucasian patients with acute myocardial infarction (AMI) in anamnesis, along with evaluation of common risk factors fo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/431 |
| Summary: | Аbstract. We have performed an analysis of associations between allelic polymorphisms of heat shock protein (HSP) genes, i.e., HSP70-2 1267А→G and HSP70-НОМ 2437Т→С in Caucasian patients with acute myocardial infarction (AMI) in anamnesis, along with evaluation of common risk factors for MI. Frequency of HSP70-HOM*TC heterozygous variant proved to be significantly higher in the group with Kettle body mass index (BMI) exceeding 25, as compared with a group of relatively healthy persons. By contrary, frequency of HSP70-HOM*CC homozygosity in the MI group with BMI > 25 was significantly lower, than among healthy persons. When comparing genotype frequencies among MI patients with BMI > 25 and those with BMI<25, significance of the differences are retained, both for HSP70-HOM*TC heterozygosity and HSP70-HOM*CC homozygous state. (Med. Immunol., 2011, vol. 13, N 1, pp 87-92) |
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| ISSN: | 1563-0625 2313-741X |