ADAPTATIONS OF NATURAL KILLER CELLS TO SELF-MHC CLASS I
Natural Killer (NK) cells use germ line encoded receptors to detect diseased host cells. Despite the invariant recognition structures, NK cells have a significant ability to adapt to their surroundings, such as the presence or absence of MHC class I molecules. It has been assumed that this adaptatio...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00349/full |
| _version_ | 1831747098083590144 |
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| author | Stéphanie eBessoles Camille eGrandclément Elisenda eAlari-Pahissa Jasmine eGehrig Beena eJeevan-Raj Werner eHeld |
| author_facet | Stéphanie eBessoles Camille eGrandclément Elisenda eAlari-Pahissa Jasmine eGehrig Beena eJeevan-Raj Werner eHeld |
| author_sort | Stéphanie eBessoles |
| collection | DOAJ |
| description | Natural Killer (NK) cells use germ line encoded receptors to detect diseased host cells. Despite the invariant recognition structures, NK cells have a significant ability to adapt to their surroundings, such as the presence or absence of MHC class I molecules. It has been assumed that this adaptation occurs during NK cell development, but recent findings show that mature NK cells can also adapt to the presence or absence of MHC class I molecules. Here, we summarize how NK cells adjust to changes in the expression of MHC class I molecules. We propose an extension of existing models, in which MHC class I recognition during NK cell development sequentially instructs and maintains NK cell function. The elucidation of the molecular basis of the two effects may identify ways to improve the fitness of NK cells and to prevent the loss of NK cell function due to persistent alterations in their environment. |
| first_indexed | 2024-12-21T21:28:07Z |
| format | Article |
| id | doaj.art-968b2f0b6bc64e9392a55f7cc11acde8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T21:28:07Z |
| publishDate | 2014-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-968b2f0b6bc64e9392a55f7cc11acde82022-12-21T18:49:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-07-01510.3389/fimmu.2014.0034989298ADAPTATIONS OF NATURAL KILLER CELLS TO SELF-MHC CLASS IStéphanie eBessoles0Camille eGrandclément1Elisenda eAlari-Pahissa2Jasmine eGehrig3Beena eJeevan-Raj4Werner eHeld5University of Lausanne University of Lausanne University of Lausanne University of Lausanne University of Lausanne University of Lausanne Natural Killer (NK) cells use germ line encoded receptors to detect diseased host cells. Despite the invariant recognition structures, NK cells have a significant ability to adapt to their surroundings, such as the presence or absence of MHC class I molecules. It has been assumed that this adaptation occurs during NK cell development, but recent findings show that mature NK cells can also adapt to the presence or absence of MHC class I molecules. Here, we summarize how NK cells adjust to changes in the expression of MHC class I molecules. We propose an extension of existing models, in which MHC class I recognition during NK cell development sequentially instructs and maintains NK cell function. The elucidation of the molecular basis of the two effects may identify ways to improve the fitness of NK cells and to prevent the loss of NK cell function due to persistent alterations in their environment.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00349/fullEducationNK cellsMHC class ILicensingLy49 receptors |
| spellingShingle | Stéphanie eBessoles Camille eGrandclément Elisenda eAlari-Pahissa Jasmine eGehrig Beena eJeevan-Raj Werner eHeld ADAPTATIONS OF NATURAL KILLER CELLS TO SELF-MHC CLASS I Frontiers in Immunology Education NK cells MHC class I Licensing Ly49 receptors |
| title | ADAPTATIONS OF NATURAL KILLER CELLS TO SELF-MHC CLASS I |
| title_full | ADAPTATIONS OF NATURAL KILLER CELLS TO SELF-MHC CLASS I |
| title_fullStr | ADAPTATIONS OF NATURAL KILLER CELLS TO SELF-MHC CLASS I |
| title_full_unstemmed | ADAPTATIONS OF NATURAL KILLER CELLS TO SELF-MHC CLASS I |
| title_short | ADAPTATIONS OF NATURAL KILLER CELLS TO SELF-MHC CLASS I |
| title_sort | adaptations of natural killer cells to self mhc class i |
| topic | Education NK cells MHC class I Licensing Ly49 receptors |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00349/full |
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