Monotropein Protects against Inflammatory Bone Loss and Suppresses Osteoclast Formation and Bone Resorption by Inhibiting NFATc1 via NF-κB and Akt/GSK-3β Pathway

Monotropein Protects against Inflammatory Bone Loss and Suppresses Osteoclast Formation and Bone Resorption by Inhibiting NFATc1 via NF-κB and Akt/GSK-3β Pathway

Monotropein (Mon) is a kind of iridoid glycoside plant secondary metabolite primarily present in some edible and medicinal plants. The aim of this study was to investigate the effect of Mon on lipopolysaccharide (LPS)-induced inflammatory bone loss in mice and osteoclasts (OCs) derived from bone mar...

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Bibliographic Details
Main Authors: Qi Zhang, Sijing Hu, Yuqiong He, Zile Song, Yi Shen, Zihui Zhao, Quanlong Zhang, Luping Qin, Qiaoyan Zhang
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Nutrients
Subjects:
monotropein
inflammatory bone loss
osteoclast
NFATc1
Akt/GSK3β pathway
Online Access:https://www.mdpi.com/2072-6643/14/19/3978

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