Risk stratification and outcomes of intracranial hemorrhage in patients with immune thrombocytopenia under 60 years of age

Risk stratification and outcomes of intracranial hemorrhage in patients with immune thrombocytopenia under 60 years of age

Intracranial hemorrhage (ICH) is a devastating complication of immune thrombocytopenia (ITP). However, information on ICH in ITP patients under the age of 60 years is limited, and no predictive tools are available in clinical practice. A total of 93 adult patients with ITP who developed ICH before 6...

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Bibliographic Details
Main Authors: Peng Zhao, Ming Hou, Yi Liu, Hui-Xin Liu, Rui-Bin Huang, Hong-Xia Yao, Ting Niu, Jun Peng, Ming Jiang, Yan-Qiu Han, Jian-Da Hu, Hu Zhou, Ze-Ping Zhou, Lin Qiu, Lian-Sheng Zhang, Xin Wang, Hua-Quan Wang, Ru Feng, Lin-Hua Yang, Liang-Ming Ma, Shun-Qing Wang, Pei-Yan Kong, Wen-Sheng Wang, Hui-Ping Sun, Jing Sun, He-Bing Zhou, Tie-Nan Zhu, Li-Ru Wang, Jing-Yu Zhang, Qiu-Sha Huang, Xiao Liu, Hai-Xia Fu, Yue-Ying Li, Qian-Fei Wang, Qian Jiang, Hao Jiang, Jin Lu, Xiao-Hui Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2021-07-01
Series:Platelets
Subjects:
immune thrombocytopenia
intracranial hemorrhage
outcome
risk stratification
Online Access:http://dx.doi.org/10.1080/09537104.2020.1786042
Description
Summary:Intracranial hemorrhage (ICH) is a devastating complication of immune thrombocytopenia (ITP). However, information on ICH in ITP patients under the age of 60 years is limited, and no predictive tools are available in clinical practice. A total of 93 adult patients with ITP who developed ICH before 60 years of age were retrospectively identified from 2005 to 2019 by 27 centers in China. For each case, 2 controls matched by the time of ITP diagnosis and the duration of ITP were provided by the same center. Multivariate analysis identified head trauma (OR = 3.216, 95%CI 1.296–7.979, P =.012), a platelet count ≤ 15,000/μL at the time of ITP diagnosis (OR = 1.679, 95%CI 1.044–2.698, P =.032) and severe/life-threatening bleeding (severe bleeding vs. mild bleeding, OR = 1.910, 95%CI 1.088–3.353, P =.024; life-threatening bleeding vs. mild bleeding, OR = 2.620, 95%CI 1.360–5.051, P =.004) as independent risk factors for ICH. Intraparenchymal hemorrhage (OR = 5.191, 95%CI 1.717–15.692, P =.004) and a history of severe bleeding (OR = 4.322, 95%CI 1.532–12.198, P =.006) were associated with the 30-day outcome of ICH. These findings may facilitate ICH risk stratification and outcome prediction in patients with ITP.
ISSN:0953-7104
1369-1635

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