A switch in transcription and cell fate governs the onset of an epigenetically-deregulated tumor in Drosophila
Tumor initiation is often linked to a loss of cellular identity. Transcriptional programs determining cellular identity are preserved by epigenetically-acting chromatin factors. Although such regulators are among the most frequently mutated genes in cancer, it is not well understood how an abnormal...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-03-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/32697 |