Emergence of KPC-producing <it>Klebsiella pneumoniae </it>in Italy
<p>Abstract</p> <p>Background</p> <p>The emergence of KPC-producing <it>K. pneumoniae </it>has now become a global concern. KPC beta-lactamases are plasmid-borne and, like extended spectrum beta lactamases (ESBLs), can accumulate and transfer resistance dete...
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| Format: | Article |
| Language: | English |
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BMC
2010-02-01
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| Series: | BMC Research Notes |
| Online Access: | http://www.biomedcentral.com/1756-0500/3/40 |
| _version_ | 1818788371954139136 |
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| author | Bossa Maria C Altieri Anna Natoli Silvia Sarmati Loredana Favaro Marco Fontana Carla Minelli Silvia Leonardis Francesca Favalli Cartesio |
| author_facet | Bossa Maria C Altieri Anna Natoli Silvia Sarmati Loredana Favaro Marco Fontana Carla Minelli Silvia Leonardis Francesca Favalli Cartesio |
| author_sort | Bossa Maria C |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The emergence of KPC-producing <it>K. pneumoniae </it>has now become a global concern. KPC beta-lactamases are plasmid-borne and, like extended spectrum beta lactamases (ESBLs), can accumulate and transfer resistance determinants to other classes of antibiotics. Therefore, infection control guidelines on early identification and control of the spread of organisms carrying these resistant determinants are needed.</p> <p>Findings</p> <p><it>Klebsiella pneumoniae </it>carbapenemase (KPC) was detected in two isolates of carbapenem-resistant <it>K. pneumoniae </it>obtained from patients at an Italian teaching hospital. The first strain was isolated from a culture drawn from a central venous device (CVC) in a patient with Crohn's disease who was admitted to a gastroenterology ward. The second was isolated from a urine sample collected from an indwelling urinary catheter in an intensive care unit (ICU) patient with a subdural haematoma. The patients had not travelled abroad. Both isolates were resistant to all β-lactams and were susceptible to imipenem and meropenem but resistant to ertapenem. Isolates also showed resistance to other classes of non-β-lactam antibiotics, such as quinolones, aminoglycosides (with the exception for amikacin), trimethoprim-sulfamethoxazole (TMP-SMX) and nitrofurantoin. They were determined to contain the plasmid encoding the carbapenemase gene <it>bla-KPC </it>and were also positive in the Hodge test.</p> <p>Conclusions</p> <p>This is the second report of KPC-producing isolates in Italy, but the first concerning KPC type 2 gene, and it may have important implications for controlling the transmission of microorganisms resistant to antibiotics.</p> |
| first_indexed | 2024-12-18T14:22:37Z |
| format | Article |
| id | doaj.art-9692d8ac5d3b46a7a1d4aebc3f5182b6 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-18T14:22:37Z |
| publishDate | 2010-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-9692d8ac5d3b46a7a1d4aebc3f5182b62022-12-21T21:04:49ZengBMCBMC Research Notes1756-05002010-02-01314010.1186/1756-0500-3-40Emergence of KPC-producing <it>Klebsiella pneumoniae </it>in ItalyBossa Maria CAltieri AnnaNatoli SilviaSarmati LoredanaFavaro MarcoFontana CarlaMinelli SilviaLeonardis FrancescaFavalli Cartesio<p>Abstract</p> <p>Background</p> <p>The emergence of KPC-producing <it>K. pneumoniae </it>has now become a global concern. KPC beta-lactamases are plasmid-borne and, like extended spectrum beta lactamases (ESBLs), can accumulate and transfer resistance determinants to other classes of antibiotics. Therefore, infection control guidelines on early identification and control of the spread of organisms carrying these resistant determinants are needed.</p> <p>Findings</p> <p><it>Klebsiella pneumoniae </it>carbapenemase (KPC) was detected in two isolates of carbapenem-resistant <it>K. pneumoniae </it>obtained from patients at an Italian teaching hospital. The first strain was isolated from a culture drawn from a central venous device (CVC) in a patient with Crohn's disease who was admitted to a gastroenterology ward. The second was isolated from a urine sample collected from an indwelling urinary catheter in an intensive care unit (ICU) patient with a subdural haematoma. The patients had not travelled abroad. Both isolates were resistant to all β-lactams and were susceptible to imipenem and meropenem but resistant to ertapenem. Isolates also showed resistance to other classes of non-β-lactam antibiotics, such as quinolones, aminoglycosides (with the exception for amikacin), trimethoprim-sulfamethoxazole (TMP-SMX) and nitrofurantoin. They were determined to contain the plasmid encoding the carbapenemase gene <it>bla-KPC </it>and were also positive in the Hodge test.</p> <p>Conclusions</p> <p>This is the second report of KPC-producing isolates in Italy, but the first concerning KPC type 2 gene, and it may have important implications for controlling the transmission of microorganisms resistant to antibiotics.</p>http://www.biomedcentral.com/1756-0500/3/40 |
| spellingShingle | Bossa Maria C Altieri Anna Natoli Silvia Sarmati Loredana Favaro Marco Fontana Carla Minelli Silvia Leonardis Francesca Favalli Cartesio Emergence of KPC-producing <it>Klebsiella pneumoniae </it>in Italy BMC Research Notes |
| title | Emergence of KPC-producing <it>Klebsiella pneumoniae </it>in Italy |
| title_full | Emergence of KPC-producing <it>Klebsiella pneumoniae </it>in Italy |
| title_fullStr | Emergence of KPC-producing <it>Klebsiella pneumoniae </it>in Italy |
| title_full_unstemmed | Emergence of KPC-producing <it>Klebsiella pneumoniae </it>in Italy |
| title_short | Emergence of KPC-producing <it>Klebsiella pneumoniae </it>in Italy |
| title_sort | emergence of kpc producing it klebsiella pneumoniae it in italy |
| url | http://www.biomedcentral.com/1756-0500/3/40 |
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