The nigrostriatal system in the presymptomatic and symptomatic stages in the MPTP monkey model: A PET, histological and biochemical study

The nigrostriatal system in the presymptomatic and symptomatic stages in the MPTP monkey model: A PET, histological and biochemical study

Parkinson's disease (PD) is diagnosed when striatal dopamine (DA) loss exceeds a certain threshold and the cardinal motor features become apparent. The presymptomatic compensatory mechanisms underlying the lack of motor manifestations despite progressive striatal depletion are not well understo...

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Bibliographic Details
Main Authors: J. Blesa, C. Pifl, M.A. Sánchez-González, C. Juri, M.A. García-Cabezas, R. Adánez, E. Iglesias, M. Collantes, I. Peñuelas, J.J. Sánchez-Hernández, M.C. Rodríguez-Oroz, C. Avendaño, O. Hornykiewicz, C. Cavada, J.A. Obeso
Format: Article
Language:English
Published: Elsevier 2012-10-01
Series:Neurobiology of Disease
Subjects:
MPTP monkey
Parkinson's disease
PET
AAAD
Compensatory mechanisms
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002045

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