A redox probe screens MTHFD1 as a determinant of gemcitabine chemoresistance in cholangiocarcinoma

A redox probe screens MTHFD1 as a determinant of gemcitabine chemoresistance in cholangiocarcinoma

Abstract Cholangiocarcinoma (CCA) is a type of solid tumor derived from the bile duct epithelium that features universal gemcitabine resistance. Here, we utilized a gene-encoded ROS biosensor probe (HyPer3 probe) to sort subpopulations with different redox statuses from CCA cells. The isolated HyPer...

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Bibliographic Details
Main Authors: Ruogu Pan, Zhiqing Yuan, Yingbin Liu, Xuxu Sun, Guiyang Wang, Xiaopen Wang, Junwen Qu, Jian Wang, Jie Yang, Yuzheng Zhao, Yi Yang, Kewei Li
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00476-2

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