Antibacterial and Physical Properties of PVM/MA Copolymer- Incorporated Polymethyl Methacrylate as a Novel Antimicrobial Acrylic Resin Material
Polymethyl methacrylate (PMMA), an acrylic resin used in orthodontic appliances and removable dentures for its biocompatibility and esthetics, may harbor bacteria on its surface. The present study investigated a new PMMA formula with Gantrez: an antibacterial copolymer of methyl vinyl ether and male...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/24/8848 |
| _version_ | 1797456023048421376 |
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| author | Christopher Lai Ashten Nguyen Lynna Ye Jessica Hao Hyun Koo Francis Mante Fusun Ozer |
| author_facet | Christopher Lai Ashten Nguyen Lynna Ye Jessica Hao Hyun Koo Francis Mante Fusun Ozer |
| author_sort | Christopher Lai |
| collection | DOAJ |
| description | Polymethyl methacrylate (PMMA), an acrylic resin used in orthodontic appliances and removable dentures for its biocompatibility and esthetics, may harbor bacteria on its surface. The present study investigated a new PMMA formula with Gantrez: an antibacterial copolymer of methyl vinyl ether and maleic acid (PVM/MA). Samples were tested for mechanical properties (surface hardness, flexural strength, water sorption, and water solubility) and effects against <i>Streptococcus mutans</i>. Six groups (0%-control, 5%, 10%, 15%, 20%, and 25% Gantrez) of <i>n</i> = 12 were fabricated for physical property tests and analyzed with one-way ANOVA and Prism 6. From these results, three groups (0%, 5%, and 10% Gantrez) were selected for antibacterial tests, and data were analyzed with one-way ANOVA and Tukey’s multiple comparison test. Adding 5% and 10% Gantrez into PMMA significantly decreased <i>S. mutans</i> adhesion. There was no significant difference between the control vs. 5%, 10%, 15%, and 20% Gantrez (<i>p</i> > 0.05) for surface hardness, the control vs. 5% Gantrez (<i>p</i> > 0.05) for flexural strength, and the control vs. 5 and 10% Gantrez for water sorption and water solubility. Overall, incorporating 5% Gantrez into PMMA may be a promising solution to reduce bacterial adhesion without changing the acrylic resin’s physical properties. |
| first_indexed | 2024-03-09T16:02:27Z |
| format | Article |
| id | doaj.art-969303b31bce4d9fa72923bb5da97afd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T16:02:27Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-969303b31bce4d9fa72923bb5da97afd2023-11-24T16:58:28ZengMDPI AGMolecules1420-30492022-12-012724884810.3390/molecules27248848Antibacterial and Physical Properties of PVM/MA Copolymer- Incorporated Polymethyl Methacrylate as a Novel Antimicrobial Acrylic Resin MaterialChristopher Lai0Ashten Nguyen1Lynna Ye2Jessica Hao3Hyun Koo4Francis Mante5Fusun Ozer6Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAPenn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USACollege of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USAPenn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Restorative Dentistry, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Restorative Dentistry, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAPolymethyl methacrylate (PMMA), an acrylic resin used in orthodontic appliances and removable dentures for its biocompatibility and esthetics, may harbor bacteria on its surface. The present study investigated a new PMMA formula with Gantrez: an antibacterial copolymer of methyl vinyl ether and maleic acid (PVM/MA). Samples were tested for mechanical properties (surface hardness, flexural strength, water sorption, and water solubility) and effects against <i>Streptococcus mutans</i>. Six groups (0%-control, 5%, 10%, 15%, 20%, and 25% Gantrez) of <i>n</i> = 12 were fabricated for physical property tests and analyzed with one-way ANOVA and Prism 6. From these results, three groups (0%, 5%, and 10% Gantrez) were selected for antibacterial tests, and data were analyzed with one-way ANOVA and Tukey’s multiple comparison test. Adding 5% and 10% Gantrez into PMMA significantly decreased <i>S. mutans</i> adhesion. There was no significant difference between the control vs. 5%, 10%, 15%, and 20% Gantrez (<i>p</i> > 0.05) for surface hardness, the control vs. 5% Gantrez (<i>p</i> > 0.05) for flexural strength, and the control vs. 5 and 10% Gantrez for water sorption and water solubility. Overall, incorporating 5% Gantrez into PMMA may be a promising solution to reduce bacterial adhesion without changing the acrylic resin’s physical properties.https://www.mdpi.com/1420-3049/27/24/8848polymethyl methacrylateacrylic resinsGantrezphysical propertiesantibacterial propertiessurface hardness |
| spellingShingle | Christopher Lai Ashten Nguyen Lynna Ye Jessica Hao Hyun Koo Francis Mante Fusun Ozer Antibacterial and Physical Properties of PVM/MA Copolymer- Incorporated Polymethyl Methacrylate as a Novel Antimicrobial Acrylic Resin Material Molecules polymethyl methacrylate acrylic resins Gantrez physical properties antibacterial properties surface hardness |
| title | Antibacterial and Physical Properties of PVM/MA Copolymer- Incorporated Polymethyl Methacrylate as a Novel Antimicrobial Acrylic Resin Material |
| title_full | Antibacterial and Physical Properties of PVM/MA Copolymer- Incorporated Polymethyl Methacrylate as a Novel Antimicrobial Acrylic Resin Material |
| title_fullStr | Antibacterial and Physical Properties of PVM/MA Copolymer- Incorporated Polymethyl Methacrylate as a Novel Antimicrobial Acrylic Resin Material |
| title_full_unstemmed | Antibacterial and Physical Properties of PVM/MA Copolymer- Incorporated Polymethyl Methacrylate as a Novel Antimicrobial Acrylic Resin Material |
| title_short | Antibacterial and Physical Properties of PVM/MA Copolymer- Incorporated Polymethyl Methacrylate as a Novel Antimicrobial Acrylic Resin Material |
| title_sort | antibacterial and physical properties of pvm ma copolymer incorporated polymethyl methacrylate as a novel antimicrobial acrylic resin material |
| topic | polymethyl methacrylate acrylic resins Gantrez physical properties antibacterial properties surface hardness |
| url | https://www.mdpi.com/1420-3049/27/24/8848 |
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