Changes of Enterocyte Morphology and Enterocyte: Goblet Cell Ratios in Dogs with Protein-Losing and Non-Protein-Losing Chronic Enteropathies
This study aimed to assess the morphometry of enterocytes as well as the goblet cell-to-enterocyte ratio in different intestinal segments of dogs with chronic enteropathies (CE). Histopathological intestinal samples from 97 dogs were included in the study (19 healthy juveniles, 21 healthy adults, 24...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/10/7/417 |
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| author | David Díaz-Regañón Vojtech Gabriel Vanessa Livania Dongjie Liu Basant H. Ahmed Addison Lincoln Hannah Wickham Abigail Ralston Maria M. Merodio Dipak K. Sahoo Christopher Zdyrski David K. Meyerholz Jonathan P. Mochel Karin Allenspach |
| author_facet | David Díaz-Regañón Vojtech Gabriel Vanessa Livania Dongjie Liu Basant H. Ahmed Addison Lincoln Hannah Wickham Abigail Ralston Maria M. Merodio Dipak K. Sahoo Christopher Zdyrski David K. Meyerholz Jonathan P. Mochel Karin Allenspach |
| author_sort | David Díaz-Regañón |
| collection | DOAJ |
| description | This study aimed to assess the morphometry of enterocytes as well as the goblet cell-to-enterocyte ratio in different intestinal segments of dogs with chronic enteropathies (CE). Histopathological intestinal samples from 97 dogs were included in the study (19 healthy juveniles, 21 healthy adults, 24 dogs with protein-losing enteropathy (PLE), and 33 CE dogs without PLE). Healthy adult small intestinal enterocytes showed progressively reduced epithelial cell height in the aboral direction, while juvenile dogs showed progressively increased epithelial cell height in the aboral direction. CE dogs had increased epithelial cell height in the duodenum, while PLE dogs had decreased epithelial cell heights compared to healthy adult dogs. Both the CE and PLE dogs showed decreased enterocyte width in the duodenal segment, and the ileal and colonic enterocytes of CE dogs were narrower than those of healthy adult dogs. CE dogs had a lower goblet cell-to-enterocyte ratio in the colon segment compared to healthy dogs. This study provides valuable morphometric information on enterocytes during canine chronic enteropathies, highlighting significant morphological enterocyte alterations, particularly in the small intestine, as well as a reduced goblet cell-to-enterocyte ratio in the colon of CE cases compared to healthy adult dogs. |
| first_indexed | 2024-03-11T00:34:22Z |
| format | Article |
| id | doaj.art-96934be958124f949c418e9822dc0a0c |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-11T00:34:22Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-96934be958124f949c418e9822dc0a0c2023-11-18T21:42:17ZengMDPI AGVeterinary Sciences2306-73812023-06-0110741710.3390/vetsci10070417Changes of Enterocyte Morphology and Enterocyte: Goblet Cell Ratios in Dogs with Protein-Losing and Non-Protein-Losing Chronic EnteropathiesDavid Díaz-Regañón0Vojtech Gabriel1Vanessa Livania2Dongjie Liu3Basant H. Ahmed4Addison Lincoln5Hannah Wickham6Abigail Ralston7Maria M. Merodio8Dipak K. Sahoo9Christopher Zdyrski10David K. Meyerholz11Jonathan P. Mochel12Karin Allenspach13Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Complutense University of Madrid, 28040 Madrid, SpainSMART Lab, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USASMART Lab, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USASMART Lab, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USASMART Lab, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USASMART Lab, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USASMART Lab, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA3D Health Solutions Inc., Ames, IA 50010, USASMART Lab, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USADepartment of Veterinary Clinical Sciences, Iowa State University, Ames, IA 50011, USASMART Lab, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USADepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USASMART Lab, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USASMART Lab, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USAThis study aimed to assess the morphometry of enterocytes as well as the goblet cell-to-enterocyte ratio in different intestinal segments of dogs with chronic enteropathies (CE). Histopathological intestinal samples from 97 dogs were included in the study (19 healthy juveniles, 21 healthy adults, 24 dogs with protein-losing enteropathy (PLE), and 33 CE dogs without PLE). Healthy adult small intestinal enterocytes showed progressively reduced epithelial cell height in the aboral direction, while juvenile dogs showed progressively increased epithelial cell height in the aboral direction. CE dogs had increased epithelial cell height in the duodenum, while PLE dogs had decreased epithelial cell heights compared to healthy adult dogs. Both the CE and PLE dogs showed decreased enterocyte width in the duodenal segment, and the ileal and colonic enterocytes of CE dogs were narrower than those of healthy adult dogs. CE dogs had a lower goblet cell-to-enterocyte ratio in the colon segment compared to healthy dogs. This study provides valuable morphometric information on enterocytes during canine chronic enteropathies, highlighting significant morphological enterocyte alterations, particularly in the small intestine, as well as a reduced goblet cell-to-enterocyte ratio in the colon of CE cases compared to healthy adult dogs.https://www.mdpi.com/2306-7381/10/7/417chronic enteropathiesinflammatory bowel diseasedogprotein-losing enteropathiesgoblet cellsenterocytes |
| spellingShingle | David Díaz-Regañón Vojtech Gabriel Vanessa Livania Dongjie Liu Basant H. Ahmed Addison Lincoln Hannah Wickham Abigail Ralston Maria M. Merodio Dipak K. Sahoo Christopher Zdyrski David K. Meyerholz Jonathan P. Mochel Karin Allenspach Changes of Enterocyte Morphology and Enterocyte: Goblet Cell Ratios in Dogs with Protein-Losing and Non-Protein-Losing Chronic Enteropathies Veterinary Sciences chronic enteropathies inflammatory bowel disease dog protein-losing enteropathies goblet cells enterocytes |
| title | Changes of Enterocyte Morphology and Enterocyte: Goblet Cell Ratios in Dogs with Protein-Losing and Non-Protein-Losing Chronic Enteropathies |
| title_full | Changes of Enterocyte Morphology and Enterocyte: Goblet Cell Ratios in Dogs with Protein-Losing and Non-Protein-Losing Chronic Enteropathies |
| title_fullStr | Changes of Enterocyte Morphology and Enterocyte: Goblet Cell Ratios in Dogs with Protein-Losing and Non-Protein-Losing Chronic Enteropathies |
| title_full_unstemmed | Changes of Enterocyte Morphology and Enterocyte: Goblet Cell Ratios in Dogs with Protein-Losing and Non-Protein-Losing Chronic Enteropathies |
| title_short | Changes of Enterocyte Morphology and Enterocyte: Goblet Cell Ratios in Dogs with Protein-Losing and Non-Protein-Losing Chronic Enteropathies |
| title_sort | changes of enterocyte morphology and enterocyte goblet cell ratios in dogs with protein losing and non protein losing chronic enteropathies |
| topic | chronic enteropathies inflammatory bowel disease dog protein-losing enteropathies goblet cells enterocytes |
| url | https://www.mdpi.com/2306-7381/10/7/417 |
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