Clozapine-induced acute gastrointestinal necrosis: a case report
Abstract Background Clozapine is known to cause fecal impaction and ileus with resultant colonic necrosis due to compression of colonic mucosa. There are rare reports of clozapine causing necrosis of other portions of the gastrointestinal tract unrelated to constipation. We describe a case of acute...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-09-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13256-017-1447-4 |
| _version_ | 1818154877692411904 |
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| author | Mark T. Osterman Caitlin Foley Isaac Matthias |
| author_facet | Mark T. Osterman Caitlin Foley Isaac Matthias |
| author_sort | Mark T. Osterman |
| collection | DOAJ |
| description | Abstract Background Clozapine is known to cause fecal impaction and ileus with resultant colonic necrosis due to compression of colonic mucosa. There are rare reports of clozapine causing necrosis of other portions of the gastrointestinal tract unrelated to constipation. We describe a case of acute necrosis of the upper gastrointestinal tract and small bowel to due to clozapine and quetiapine. Case presentation A 66-year-old white man with a past medical history of schizophrenia, maintained on clozapine and quetiapine, presented with hypoxic respiratory failure caused by aspiration of feculent emesis due to impacted stool throughout his colon. His constipation resolved with discontinuation of clozapine and quetiapine, and his clinical condition improved. These medicines were restarted after 2 weeks, resulting in acute gastrointestinal necrosis from the mid esophagus through his entire small bowel. He died due to septic shock with Gram-negative rod bacteremia. Conclusions Clozapine may cause acute gastrointestinal necrosis. |
| first_indexed | 2024-12-11T14:33:30Z |
| format | Article |
| id | doaj.art-96944fe86ea849789c2cd0ba0883ca89 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-11T14:33:30Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-96944fe86ea849789c2cd0ba0883ca892022-12-22T01:02:18ZengBMCJournal of Medical Case Reports1752-19472017-09-011111310.1186/s13256-017-1447-4Clozapine-induced acute gastrointestinal necrosis: a case reportMark T. Osterman0Caitlin Foley1Isaac Matthias2Division of Gastroenterology, Perelman School of Medicine, University of PennsylvaniaDivision of Gastroenterology, Perelman School of Medicine, University of PennsylvaniaSection of Hospital Medicine, Perelman School of Medicine, University of PennsylvaniaAbstract Background Clozapine is known to cause fecal impaction and ileus with resultant colonic necrosis due to compression of colonic mucosa. There are rare reports of clozapine causing necrosis of other portions of the gastrointestinal tract unrelated to constipation. We describe a case of acute necrosis of the upper gastrointestinal tract and small bowel to due to clozapine and quetiapine. Case presentation A 66-year-old white man with a past medical history of schizophrenia, maintained on clozapine and quetiapine, presented with hypoxic respiratory failure caused by aspiration of feculent emesis due to impacted stool throughout his colon. His constipation resolved with discontinuation of clozapine and quetiapine, and his clinical condition improved. These medicines were restarted after 2 weeks, resulting in acute gastrointestinal necrosis from the mid esophagus through his entire small bowel. He died due to septic shock with Gram-negative rod bacteremia. Conclusions Clozapine may cause acute gastrointestinal necrosis.http://link.springer.com/article/10.1186/s13256-017-1447-4ClozapineQuetiapineAntipsychoticAcute gastrointestinal necrosisAcute bowel necrosisAcute esophageal necrosis |
| spellingShingle | Mark T. Osterman Caitlin Foley Isaac Matthias Clozapine-induced acute gastrointestinal necrosis: a case report Journal of Medical Case Reports Clozapine Quetiapine Antipsychotic Acute gastrointestinal necrosis Acute bowel necrosis Acute esophageal necrosis |
| title | Clozapine-induced acute gastrointestinal necrosis: a case report |
| title_full | Clozapine-induced acute gastrointestinal necrosis: a case report |
| title_fullStr | Clozapine-induced acute gastrointestinal necrosis: a case report |
| title_full_unstemmed | Clozapine-induced acute gastrointestinal necrosis: a case report |
| title_short | Clozapine-induced acute gastrointestinal necrosis: a case report |
| title_sort | clozapine induced acute gastrointestinal necrosis a case report |
| topic | Clozapine Quetiapine Antipsychotic Acute gastrointestinal necrosis Acute bowel necrosis Acute esophageal necrosis |
| url | http://link.springer.com/article/10.1186/s13256-017-1447-4 |
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