Investigating the crosstalk between chronic stress and immune cells: implications for enhanced cancer therapy
Chronic stress has a substantial influence on the tumor microenvironment (TME), leading to compromised effectiveness of anti-cancer therapies through diverse mechanisms. It disrupts vital functions of immune cells that play a critical role in anti-tumor immunity, such as the inhibition of dendritic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1321176/full |
| _version_ | 1797449575617789952 |
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| author | YongRong Lei YongRong Lei Fenghui Liao YiChen Tian YaNi Wang Feng Xia JianHua Wang |
| author_facet | YongRong Lei YongRong Lei Fenghui Liao YiChen Tian YaNi Wang Feng Xia JianHua Wang |
| author_sort | YongRong Lei |
| collection | DOAJ |
| description | Chronic stress has a substantial influence on the tumor microenvironment (TME), leading to compromised effectiveness of anti-cancer therapies through diverse mechanisms. It disrupts vital functions of immune cells that play a critical role in anti-tumor immunity, such as the inhibition of dendritic cells (DCs) and lymphocytes, while simultaneously enhancing the activity of immune cells that support tumor growth, such as myeloid-derived suppressor cells and tumor-associated macrophages. Furthermore, chronic stress exerts a significant impact on crucial mechanisms within the TME, including angiogenesis, DNA repair, hypoxia, extracellular matrix deposition, and tumor metabolism. These alterations in the TME, induced by stress, result from the activation of the hypothalamic–pituitary–adrenal axis and sympathetic nervous system, in conjunction with epigenetic modifications. In conclusion, chronic stress significantly influences the TME and impedes the efficacy of anti-cancer treatments, underscoring the importance of targeting stress pathways to improve therapeutic results. |
| first_indexed | 2024-03-09T14:27:01Z |
| format | Article |
| id | doaj.art-9695245e95524b708488bbe5fe058ce6 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-09T14:27:01Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-9695245e95524b708488bbe5fe058ce62023-11-28T06:00:44ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-11-011710.3389/fnins.2023.13211761321176Investigating the crosstalk between chronic stress and immune cells: implications for enhanced cancer therapyYongRong Lei0YongRong Lei1Fenghui Liao2YiChen Tian3YaNi Wang4Feng Xia5JianHua Wang6Key Laboratory of Biorheological Science and Technology (Ministry of Education), College of Bioengineering, Chongqing University, Chongqing, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaKey Laboratory of Biorheological Science and Technology (Ministry of Education), College of Bioengineering, Chongqing University, Chongqing, ChinaKey Laboratory of Biorheological Science and Technology (Ministry of Education), College of Bioengineering, Chongqing University, Chongqing, ChinaKey Laboratory of Biorheological Science and Technology (Ministry of Education), College of Bioengineering, Chongqing University, Chongqing, ChinaKey Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaKey Laboratory of Biorheological Science and Technology (Ministry of Education), College of Bioengineering, Chongqing University, Chongqing, ChinaChronic stress has a substantial influence on the tumor microenvironment (TME), leading to compromised effectiveness of anti-cancer therapies through diverse mechanisms. It disrupts vital functions of immune cells that play a critical role in anti-tumor immunity, such as the inhibition of dendritic cells (DCs) and lymphocytes, while simultaneously enhancing the activity of immune cells that support tumor growth, such as myeloid-derived suppressor cells and tumor-associated macrophages. Furthermore, chronic stress exerts a significant impact on crucial mechanisms within the TME, including angiogenesis, DNA repair, hypoxia, extracellular matrix deposition, and tumor metabolism. These alterations in the TME, induced by stress, result from the activation of the hypothalamic–pituitary–adrenal axis and sympathetic nervous system, in conjunction with epigenetic modifications. In conclusion, chronic stress significantly influences the TME and impedes the efficacy of anti-cancer treatments, underscoring the importance of targeting stress pathways to improve therapeutic results.https://www.frontiersin.org/articles/10.3389/fnins.2023.1321176/fullchronic stresstumor microenvironmentimmunotherapyanticancer treatmentssympathetic nervous systemneural-immune interactions |
| spellingShingle | YongRong Lei YongRong Lei Fenghui Liao YiChen Tian YaNi Wang Feng Xia JianHua Wang Investigating the crosstalk between chronic stress and immune cells: implications for enhanced cancer therapy Frontiers in Neuroscience chronic stress tumor microenvironment immunotherapy anticancer treatments sympathetic nervous system neural-immune interactions |
| title | Investigating the crosstalk between chronic stress and immune cells: implications for enhanced cancer therapy |
| title_full | Investigating the crosstalk between chronic stress and immune cells: implications for enhanced cancer therapy |
| title_fullStr | Investigating the crosstalk between chronic stress and immune cells: implications for enhanced cancer therapy |
| title_full_unstemmed | Investigating the crosstalk between chronic stress and immune cells: implications for enhanced cancer therapy |
| title_short | Investigating the crosstalk between chronic stress and immune cells: implications for enhanced cancer therapy |
| title_sort | investigating the crosstalk between chronic stress and immune cells implications for enhanced cancer therapy |
| topic | chronic stress tumor microenvironment immunotherapy anticancer treatments sympathetic nervous system neural-immune interactions |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1321176/full |
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