ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS
Abstract. We have carried out a prevalence analysis of IL6 (-174 G/C) gene promoter polymorphism and traditional cardiovascular risk factors in male patients living in the West Siberia that survived myocardial infarction (MI) in their anamnesis. Analysis of genotype frequencies have shown decrease o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/367 |
| _version_ | 1826534337443528704 |
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| author | A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov O. M. Tolkacheva |
| author_facet | A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov O. M. Tolkacheva |
| author_sort | A. V. Shevchenko |
| collection | DOAJ |
| description | Abstract. We have carried out a prevalence analysis of IL6 (-174 G/C) gene promoter polymorphism and traditional cardiovascular risk factors in male patients living in the West Siberia that survived myocardial infarction (MI) in their anamnesis. Analysis of genotype frequencies have shown decrease of *-174 GG genotype in the patients with MI. Frequency of the same genotype is decreased among smoking patients as compared to healthy non-smokers. On other hand, an increased body weight and arterial pressure indexes increase is found in IL6*-174 G patients, versus healthy population. Hence, the analyzed IL6 (-174 G/C) polymorphism may be considered as an additional predisposition factor for development of vascular damage. |
| first_indexed | 2024-03-08T05:50:51Z |
| format | Article |
| id | doaj.art-9695a7cc11204797b15151cf32e1b50d |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:21:25Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-9695a7cc11204797b15151cf32e1b50d2025-03-11T17:59:02ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0111655756610.15789/1563-0625-2009-6-557-566364ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONSA. V. Shevchenko0O. V. Golovanova1V. I. Konenkov2M. I. Voevoda3V. N. Maximov4O. M. Tolkacheva5НИИ клинической и экспериментальной лимфологии СО РАМН, г. НовосибирскНИИ клинической и экспериментальной лимфологии СО РАМН, г. НовосибирскНИИ клинической и экспериментальной лимфологии СО РАМН, г. НовосибирскНИИ терапии СО РАМН, г. НовосибирскНИИ терапии СО РАМН, г. НовосибирскМУЗ Городская клиническая больница № 29, г. НовокузнецкAbstract. We have carried out a prevalence analysis of IL6 (-174 G/C) gene promoter polymorphism and traditional cardiovascular risk factors in male patients living in the West Siberia that survived myocardial infarction (MI) in their anamnesis. Analysis of genotype frequencies have shown decrease of *-174 GG genotype in the patients with MI. Frequency of the same genotype is decreased among smoking patients as compared to healthy non-smokers. On other hand, an increased body weight and arterial pressure indexes increase is found in IL6*-174 G patients, versus healthy population. Hence, the analyzed IL6 (-174 G/C) polymorphism may be considered as an additional predisposition factor for development of vascular damage.https://www.mimmun.ru/mimmun/article/view/367myocardial infarctionpolymorphism il-6cardiovascular risk factors |
| spellingShingle | A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov O. M. Tolkacheva ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS Медицинская иммунология myocardial infarction polymorphism il-6 cardiovascular risk factors |
| title | ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS |
| title_full | ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS |
| title_fullStr | ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS |
| title_full_unstemmed | ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS |
| title_short | ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS |
| title_sort | analysis of correlation between il 6 gene polymorphism 174 g c and classic risk factors in patients with previous myocardial infarctions |
| topic | myocardial infarction polymorphism il-6 cardiovascular risk factors |
| url | https://www.mimmun.ru/mimmun/article/view/367 |
| work_keys_str_mv | AT avshevchenko analysisofcorrelationbetweenil6genepolymorphism174gcandclassicriskfactorsinpatientswithpreviousmyocardialinfarctions AT ovgolovanova analysisofcorrelationbetweenil6genepolymorphism174gcandclassicriskfactorsinpatientswithpreviousmyocardialinfarctions AT vikonenkov analysisofcorrelationbetweenil6genepolymorphism174gcandclassicriskfactorsinpatientswithpreviousmyocardialinfarctions AT mivoevoda analysisofcorrelationbetweenil6genepolymorphism174gcandclassicriskfactorsinpatientswithpreviousmyocardialinfarctions AT vnmaximov analysisofcorrelationbetweenil6genepolymorphism174gcandclassicriskfactorsinpatientswithpreviousmyocardialinfarctions AT omtolkacheva analysisofcorrelationbetweenil6genepolymorphism174gcandclassicriskfactorsinpatientswithpreviousmyocardialinfarctions |