Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia
Electroencephalography (EEG) is widely used for monitoring the depth of anesthesia in surgical patients. Distinguishing age-related EEG features under general anesthesia will help to optimize anesthetic depth monitoring during surgery for elderly patients. This retrospective cohort study included 41...
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MDPI AG
2023-07-01
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| Online Access: | https://www.mdpi.com/2076-3425/13/8/1149 |
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| author | Xinxin Zhang Ao Li Sa Wang Tingting Wang Tiantian Liu Yonghui Wang Jingwen Fu Guangchao Zhao Qianzi Yang Hailong Dong |
| author_facet | Xinxin Zhang Ao Li Sa Wang Tingting Wang Tiantian Liu Yonghui Wang Jingwen Fu Guangchao Zhao Qianzi Yang Hailong Dong |
| author_sort | Xinxin Zhang |
| collection | DOAJ |
| description | Electroencephalography (EEG) is widely used for monitoring the depth of anesthesia in surgical patients. Distinguishing age-related EEG features under general anesthesia will help to optimize anesthetic depth monitoring during surgery for elderly patients. This retrospective cohort study included 41 patients aged from 18 to 79 years undergoing noncardiac surgery under general anesthesia. We compared the power spectral signatures and phase–amplitude coupling patterns of the young and elderly groups under baseline and surgical anesthetic depth. General anesthesia by sevoflurane significantly increased the spectral power of delta, theta, alpha, and beta bands and strengthened the cross-frequency coupling both in young and elderly patients. However, the variation in EEG power spectral density and the modulation of alpha amplitudes on delta phases was relatively weaker in elderly patients. In conclusion, the EEG under general anesthesia using sevoflurane exhibited similar dynamic features between young and elderly patients, and the weakened alteration of spectral power and cross-frequency coupling patterns could be utilized to precisely quantify the depth of anesthesia in elderly patients. |
| first_indexed | 2024-03-11T00:05:35Z |
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| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T00:05:35Z |
| publishDate | 2023-07-01 |
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| spelling | doaj.art-96962f34172948f490cae89a7732fa2b2023-11-19T00:26:24ZengMDPI AGBrain Sciences2076-34252023-07-01138114910.3390/brainsci13081149Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane AnesthesiaXinxin Zhang0Ao Li1Sa Wang2Tingting Wang3Tiantian Liu4Yonghui Wang5Jingwen Fu6Guangchao Zhao7Qianzi Yang8Hailong Dong9Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710000, ChinaDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710000, ChinaDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710000, ChinaDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710000, ChinaDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710000, ChinaDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710000, ChinaDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710000, ChinaDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710000, ChinaDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710000, ChinaDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710000, ChinaElectroencephalography (EEG) is widely used for monitoring the depth of anesthesia in surgical patients. Distinguishing age-related EEG features under general anesthesia will help to optimize anesthetic depth monitoring during surgery for elderly patients. This retrospective cohort study included 41 patients aged from 18 to 79 years undergoing noncardiac surgery under general anesthesia. We compared the power spectral signatures and phase–amplitude coupling patterns of the young and elderly groups under baseline and surgical anesthetic depth. General anesthesia by sevoflurane significantly increased the spectral power of delta, theta, alpha, and beta bands and strengthened the cross-frequency coupling both in young and elderly patients. However, the variation in EEG power spectral density and the modulation of alpha amplitudes on delta phases was relatively weaker in elderly patients. In conclusion, the EEG under general anesthesia using sevoflurane exhibited similar dynamic features between young and elderly patients, and the weakened alteration of spectral power and cross-frequency coupling patterns could be utilized to precisely quantify the depth of anesthesia in elderly patients.https://www.mdpi.com/2076-3425/13/8/1149general anesthesiaEEG monitoringaging brain |
| spellingShingle | Xinxin Zhang Ao Li Sa Wang Tingting Wang Tiantian Liu Yonghui Wang Jingwen Fu Guangchao Zhao Qianzi Yang Hailong Dong Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia Brain Sciences general anesthesia EEG monitoring aging brain |
| title | Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia |
| title_full | Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia |
| title_fullStr | Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia |
| title_full_unstemmed | Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia |
| title_short | Differences in the EEG Power Spectrum and Cross-Frequency Coupling Patterns between Young and Elderly Patients during Sevoflurane Anesthesia |
| title_sort | differences in the eeg power spectrum and cross frequency coupling patterns between young and elderly patients during sevoflurane anesthesia |
| topic | general anesthesia EEG monitoring aging brain |
| url | https://www.mdpi.com/2076-3425/13/8/1149 |
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