Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis
ObjectiveDifferentiated thyroid cancer (DTC) is rare in childhood and adolescence although it represents the most frequent endocrine malignancy in this population. DTC includes both papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC). Most pediatric DTCs are PTCs, while FTCs are...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1270518/full |
| _version_ | 1797680773388566528 |
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| author | Mariacarla Moleti Tommaso Aversa Salvatore Crisafulli Gianluca Trifirò Domenico Corica Giorgia Pepe Laura Cannavò Maria Di Mauro Giuseppe Paola Andrea Fontana Fabrizio Calapai Salvatore Cannavò Malgorzata Wasniewska |
| author_facet | Mariacarla Moleti Tommaso Aversa Salvatore Crisafulli Gianluca Trifirò Domenico Corica Giorgia Pepe Laura Cannavò Maria Di Mauro Giuseppe Paola Andrea Fontana Fabrizio Calapai Salvatore Cannavò Malgorzata Wasniewska |
| author_sort | Mariacarla Moleti |
| collection | DOAJ |
| description | ObjectiveDifferentiated thyroid cancer (DTC) is rare in childhood and adolescence although it represents the most frequent endocrine malignancy in this population. DTC includes both papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC). Most pediatric DTCs are PTCs, while FTCs are rare. To date, no systematic reviews on the global epidemiology of pediatric and adolescent DTC have been published. This systematic review and meta-analysis aims to estimate the overall incidence and prevalence of DTCs in patients aged 0–19 years.MethodsThe systematic research was conducted from January 2000 to December 2021 through MEDLINE via PubMed, Cochrane Library, and Embase databases. Two separate meta-analyses were performed for PTC and FTC.ResultsAfter the selection phase, a total of 15 studies (3,332 screened) met the inclusion criteria and are reported in the present systematic review. Five studies were conducted in Europe, five in North America, two in South America, one in Asia, one reported data for 49 countries and territories across the five continents, and one from both the USA and Africa. Most of the studies (n = 14) reported data obtained from national registries, and only one provided information collected from hospital medical records. Beyond the actual trend over time, our study reported a pooled global incidence rate (IR) of PTC and FTC in the pediatric age of 0.46 (95% CI: 0.33–0.59) and 0.07 (95% CI: 0.02–0.12) per 100,000 person-years, respectively. The highest IRs were recorded among Caucasian girls, and the lowest in black or other races/ethnicities.ConclusionOur data confirm that DTC in the pediatric population is a rare condition. The pooled IRs of the studies included in this meta-analysis are ~0.5 for PTC, which is the most common histological type when both genders and all age groups are considered. The implementation of a prospective international registry on pediatric DTC, as part of the wider European Registries for Rare Endocrine Conditions, has been recently proposed. In addition to providing relevant information on the clinical behavior of this rare disease, standardization of data collection will be pivotal to fill current gaps and allow an accurate estimation of the real incidence and risk factors of DTC. |
| first_indexed | 2024-03-11T23:35:09Z |
| format | Article |
| id | doaj.art-96981e3d890444349513b1bda9c9ec3d |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T23:35:09Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-96981e3d890444349513b1bda9c9ec3d2023-09-20T04:43:40ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-09-011410.3389/fendo.2023.12705181270518Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysisMariacarla Moleti0Tommaso Aversa1Salvatore Crisafulli2Gianluca Trifirò3Domenico Corica4Giorgia Pepe5Laura Cannavò6Maria Di Mauro7Giuseppe Paola8Andrea Fontana9Fabrizio Calapai10Salvatore Cannavò11Malgorzata Wasniewska12Department of Clinical and Experimental Medicine, University of Messina, Messina, ItalyDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Messina, ItalyDepartment of Medicine, University of Verona, Verona, ItalyDepartment of Diagnostics and Public Health, University of Verona, Verona, ItalyDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Messina, ItalyDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Messina, ItalyDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Messina, ItalyUnit of Endocrinology, University Hospital Policlinico “G. Martino”, Messina, ItalyUnit of Biostatistics, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, ItalyDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Messina, ItalyDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Messina, ItalyObjectiveDifferentiated thyroid cancer (DTC) is rare in childhood and adolescence although it represents the most frequent endocrine malignancy in this population. DTC includes both papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC). Most pediatric DTCs are PTCs, while FTCs are rare. To date, no systematic reviews on the global epidemiology of pediatric and adolescent DTC have been published. This systematic review and meta-analysis aims to estimate the overall incidence and prevalence of DTCs in patients aged 0–19 years.MethodsThe systematic research was conducted from January 2000 to December 2021 through MEDLINE via PubMed, Cochrane Library, and Embase databases. Two separate meta-analyses were performed for PTC and FTC.ResultsAfter the selection phase, a total of 15 studies (3,332 screened) met the inclusion criteria and are reported in the present systematic review. Five studies were conducted in Europe, five in North America, two in South America, one in Asia, one reported data for 49 countries and territories across the five continents, and one from both the USA and Africa. Most of the studies (n = 14) reported data obtained from national registries, and only one provided information collected from hospital medical records. Beyond the actual trend over time, our study reported a pooled global incidence rate (IR) of PTC and FTC in the pediatric age of 0.46 (95% CI: 0.33–0.59) and 0.07 (95% CI: 0.02–0.12) per 100,000 person-years, respectively. The highest IRs were recorded among Caucasian girls, and the lowest in black or other races/ethnicities.ConclusionOur data confirm that DTC in the pediatric population is a rare condition. The pooled IRs of the studies included in this meta-analysis are ~0.5 for PTC, which is the most common histological type when both genders and all age groups are considered. The implementation of a prospective international registry on pediatric DTC, as part of the wider European Registries for Rare Endocrine Conditions, has been recently proposed. In addition to providing relevant information on the clinical behavior of this rare disease, standardization of data collection will be pivotal to fill current gaps and allow an accurate estimation of the real incidence and risk factors of DTC.https://www.frontiersin.org/articles/10.3389/fendo.2023.1270518/fulldifferentiated thyroid cancerpapillary thyroid carcinomafollicular thyroid carcinomachildrenmeta-analysisincidence |
| spellingShingle | Mariacarla Moleti Tommaso Aversa Salvatore Crisafulli Gianluca Trifirò Domenico Corica Giorgia Pepe Laura Cannavò Maria Di Mauro Giuseppe Paola Andrea Fontana Fabrizio Calapai Salvatore Cannavò Malgorzata Wasniewska Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis Frontiers in Endocrinology differentiated thyroid cancer papillary thyroid carcinoma follicular thyroid carcinoma children meta-analysis incidence |
| title | Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis |
| title_full | Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis |
| title_fullStr | Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis |
| title_full_unstemmed | Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis |
| title_short | Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis |
| title_sort | global incidence and prevalence of differentiated thyroid cancer in childhood systematic review and meta analysis |
| topic | differentiated thyroid cancer papillary thyroid carcinoma follicular thyroid carcinoma children meta-analysis incidence |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1270518/full |
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