Prognostic significance of tumor regression grade in esophageal squamous cell carcinoma after neoadjuvant chemoradiation
BackgroundsTrimodal therapy (neoadjuvant chemoradiotherapy followed by esophagectomy) for locally advanced esophageal squamous cell carcinoma (ESCC) is associated with a significant survival benefit. Modified Ryan score is an effective tool to evaluated the tumor regression grade (TRG) after neoadju...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1029575/full |
| _version_ | 1797960131366879232 |
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| author | Chi Zhang Fei Xu Yong Qiang Zhuang-Zhuang Cong Qin Wang Zheng Zhang Chao Luo Bing-Mei Qiu Li-Wen Hu Yi Shen Yi Shen Yi Shen Yi Shen Yi Shen |
| author_facet | Chi Zhang Fei Xu Yong Qiang Zhuang-Zhuang Cong Qin Wang Zheng Zhang Chao Luo Bing-Mei Qiu Li-Wen Hu Yi Shen Yi Shen Yi Shen Yi Shen Yi Shen |
| author_sort | Chi Zhang |
| collection | DOAJ |
| description | BackgroundsTrimodal therapy (neoadjuvant chemoradiotherapy followed by esophagectomy) for locally advanced esophageal squamous cell carcinoma (ESCC) is associated with a significant survival benefit. Modified Ryan score is an effective tool to evaluated the tumor regression grade (TRG) after neoadjuvant therapy. The aim of this study was to evaluate the prognostic value of TRG for overall survival (OS) and disease-free survival (DFS) in ESCC patients undergoing neoadjuvant chemoradiation.MethodsThe study retrospectively reviewed 523 ESCC patients who underwent neoadjuvant chemoradiotherapy and radical esophagectomy at Jinling Hospital from January 2014 to July 2020. Kaplan–Meier curves with log-rank test and Cox regression model were used to evaluate the prognostic factor of TRG based on modified Ryan scoring system on OS and DFS.ResultsAfter application of inclusion and exclusion criteria, 494 patients with ESCC following neoadjuvant chemoradiotherapy and radical esophagectomy were available for analysis. The TRG scores are significantly associated with smoke history (p = 0.02), lymphovascular invasion (LVI) and/or peripheral nerve invasion (PNI) (p < 0.01), and postoperative adjuvant therapy (p < 0.01). Meanwhile, tumor characteristics including tumor length (p < 0.01) and tumor differentiation grade (p < 0.01) are also significantly associated with TRG score. The results of multivariable Cox regression modal showed that TRG is not an independently prognostic factor for OS (p = 0.922) or DFS (p = 0.526) but tumor length is an independently prognostic factor for DFS (p = 0.046).ConclusionsThis study evaluated the prognostic value of modified Ryan scoring system for ESCC after trimodal therapy and concluded that modified Ryan scoring system can predict survival and recurrence rates but is not an independently prognostic factor for OS and DFS. |
| first_indexed | 2024-04-11T00:41:36Z |
| format | Article |
| id | doaj.art-9698b312ca75475c818114e2d0426ce0 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-11T00:41:36Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-9698b312ca75475c818114e2d0426ce02023-01-06T05:42:46ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2023-01-01910.3389/fsurg.2022.10295751029575Prognostic significance of tumor regression grade in esophageal squamous cell carcinoma after neoadjuvant chemoradiationChi Zhang0Fei Xu1Yong Qiang2Zhuang-Zhuang Cong3Qin Wang4Zheng Zhang5Chao Luo6Bing-Mei Qiu7Li-Wen Hu8Yi Shen9Yi Shen10Yi Shen11Yi Shen12Yi Shen13Department of Cardiothoracic Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Cardiothoracic Surgery, Jinling Hospital, School of Clinical Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Cardiothoracic Surgery, Jinling Hospital, School of Medicine, Southeast University, Nanjing, ChinaDepartment of Cardiothoracic Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Cardiothoracic Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Cardiothoracic Surgery, Jinling Hospital, School of Clinical Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Cardiothoracic Surgery, Jinling Hospital, School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Cardiothoracic Surgery, Jinling Hospital, Nanjing, ChinaDepartment of Cardiothoracic Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Cardiothoracic Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Cardiothoracic Surgery, Jinling Hospital, School of Clinical Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Cardiothoracic Surgery, Jinling Hospital, School of Medicine, Southeast University, Nanjing, ChinaDepartment of Cardiothoracic Surgery, Jinling Hospital, School of Clinical Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Cardiothoracic Surgery, Jinling Hospital, Nanjing, ChinaBackgroundsTrimodal therapy (neoadjuvant chemoradiotherapy followed by esophagectomy) for locally advanced esophageal squamous cell carcinoma (ESCC) is associated with a significant survival benefit. Modified Ryan score is an effective tool to evaluated the tumor regression grade (TRG) after neoadjuvant therapy. The aim of this study was to evaluate the prognostic value of TRG for overall survival (OS) and disease-free survival (DFS) in ESCC patients undergoing neoadjuvant chemoradiation.MethodsThe study retrospectively reviewed 523 ESCC patients who underwent neoadjuvant chemoradiotherapy and radical esophagectomy at Jinling Hospital from January 2014 to July 2020. Kaplan–Meier curves with log-rank test and Cox regression model were used to evaluate the prognostic factor of TRG based on modified Ryan scoring system on OS and DFS.ResultsAfter application of inclusion and exclusion criteria, 494 patients with ESCC following neoadjuvant chemoradiotherapy and radical esophagectomy were available for analysis. The TRG scores are significantly associated with smoke history (p = 0.02), lymphovascular invasion (LVI) and/or peripheral nerve invasion (PNI) (p < 0.01), and postoperative adjuvant therapy (p < 0.01). Meanwhile, tumor characteristics including tumor length (p < 0.01) and tumor differentiation grade (p < 0.01) are also significantly associated with TRG score. The results of multivariable Cox regression modal showed that TRG is not an independently prognostic factor for OS (p = 0.922) or DFS (p = 0.526) but tumor length is an independently prognostic factor for DFS (p = 0.046).ConclusionsThis study evaluated the prognostic value of modified Ryan scoring system for ESCC after trimodal therapy and concluded that modified Ryan scoring system can predict survival and recurrence rates but is not an independently prognostic factor for OS and DFS.https://www.frontiersin.org/articles/10.3389/fsurg.2022.1029575/fullesophageal squamous cell carcinomaneoadjuvant chemoradiotherapyesophagectomytumor regression grademodified ryan scoring system |
| spellingShingle | Chi Zhang Fei Xu Yong Qiang Zhuang-Zhuang Cong Qin Wang Zheng Zhang Chao Luo Bing-Mei Qiu Li-Wen Hu Yi Shen Yi Shen Yi Shen Yi Shen Yi Shen Prognostic significance of tumor regression grade in esophageal squamous cell carcinoma after neoadjuvant chemoradiation Frontiers in Surgery esophageal squamous cell carcinoma neoadjuvant chemoradiotherapy esophagectomy tumor regression grade modified ryan scoring system |
| title | Prognostic significance of tumor regression grade in esophageal squamous cell carcinoma after neoadjuvant chemoradiation |
| title_full | Prognostic significance of tumor regression grade in esophageal squamous cell carcinoma after neoadjuvant chemoradiation |
| title_fullStr | Prognostic significance of tumor regression grade in esophageal squamous cell carcinoma after neoadjuvant chemoradiation |
| title_full_unstemmed | Prognostic significance of tumor regression grade in esophageal squamous cell carcinoma after neoadjuvant chemoradiation |
| title_short | Prognostic significance of tumor regression grade in esophageal squamous cell carcinoma after neoadjuvant chemoradiation |
| title_sort | prognostic significance of tumor regression grade in esophageal squamous cell carcinoma after neoadjuvant chemoradiation |
| topic | esophageal squamous cell carcinoma neoadjuvant chemoradiotherapy esophagectomy tumor regression grade modified ryan scoring system |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1029575/full |
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