Codon-optimization in gene therapy: promises, prospects and challenges

Codon-optimization in gene therapy: promises, prospects and challenges

Codon optimization has evolved to enhance protein expression efficiency by exploiting the genetic code’s redundancy, allowing for multiple codon options for a single amino acid. Initially observed in E. coli, optimal codon usage correlates with high gene expression, which has propelled applications...

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Bibliographic Details
Main Authors: Anastasiia Iu Paremskaia, Anna A. Kogan, Anastasiia Murashkina, Daria A. Naumova, Anakha Satish, Ivan S. Abramov, Sofya G. Feoktistova, Olga N. Mityaeva, Andrei A. Deviatkin, Pavel Yu Volchkov
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
gene therapy
codon-optimization metrics
mRNA
immunogenicity
clinical trials
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1371596/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2024.1371596/full

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