Clinical outcomes of paliperidone long-acting injection in patients with schizophrenia: a 1-year retrospective cohort study
Abstract Background Schizophrenia is a severe psychiatric disorder. Poor medical adherence increases relapse rate. Long-acting injection of antipsychotic agent is developed for improving medical adherence. In this study, we examined the effect of paliperidone long-acting injection (PLAI) treatment i...
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-021-03513-7 |
| _version_ | 1819259389878468608 |
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| author | Hsue-Wei Chan Chin-Yu Huang Yung-Chieh Yen |
| author_facet | Hsue-Wei Chan Chin-Yu Huang Yung-Chieh Yen |
| author_sort | Hsue-Wei Chan |
| collection | DOAJ |
| description | Abstract Background Schizophrenia is a severe psychiatric disorder. Poor medical adherence increases relapse rate. Long-acting injection of antipsychotic agent is developed for improving medical adherence. In this study, we examined the effect of paliperidone long-acting injection (PLAI) treatment in patients with schizophrenia in a real-world setting. Methods In this retrospective cohort study, 467 patients with schizophrenia were enrolled, treated with risperidone PLAI or oral antipsychotics, and followed for 1 year. Concomitant medication, namely anticonvulsants, antidepressants, anxiolytics, sedatives or hypnotics, anticholinergics, and beta-blockers, were administered. Patients were classified into 2 groups: the LAI group (patients received LAI for treatment) and the NLAI group (patients taking only oral antipsychotics). The incidence of hospitalization, the length of hospitalization, and the incidence of emergency room visits were assessed. Results The LAI group had a higher incidence of psychiatric acute ward admission (NLAI group = 4.8%; LAI = 30.3%) and emergency room visits (NLAI group = 7.3%; LAI group = 36.0%) before enrolment. During the one-year follow-up, the incidence of acute ward admission and emergency room visit did not differ in the NLAI group (P = .586 and .241) compared with before enrolment, whereas both incidences were significantly decreased in the LAI group (P < .0001 in both of them). Conclusions PLAI reduces the incidence of admission and emergency room visits. |
| first_indexed | 2024-12-23T19:09:14Z |
| format | Article |
| id | doaj.art-969c24bc65df4a3eb39ea7774cda991d |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-23T19:09:14Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-969c24bc65df4a3eb39ea7774cda991d2022-12-21T17:34:30ZengBMCBMC Psychiatry1471-244X2021-10-012111810.1186/s12888-021-03513-7Clinical outcomes of paliperidone long-acting injection in patients with schizophrenia: a 1-year retrospective cohort studyHsue-Wei Chan0Chin-Yu Huang1Yung-Chieh Yen2Department of Psychiatry, E-Da HospitalDepartment of Psychiatry, E-Da HospitalDepartment of Psychiatry, E-Da HospitalAbstract Background Schizophrenia is a severe psychiatric disorder. Poor medical adherence increases relapse rate. Long-acting injection of antipsychotic agent is developed for improving medical adherence. In this study, we examined the effect of paliperidone long-acting injection (PLAI) treatment in patients with schizophrenia in a real-world setting. Methods In this retrospective cohort study, 467 patients with schizophrenia were enrolled, treated with risperidone PLAI or oral antipsychotics, and followed for 1 year. Concomitant medication, namely anticonvulsants, antidepressants, anxiolytics, sedatives or hypnotics, anticholinergics, and beta-blockers, were administered. Patients were classified into 2 groups: the LAI group (patients received LAI for treatment) and the NLAI group (patients taking only oral antipsychotics). The incidence of hospitalization, the length of hospitalization, and the incidence of emergency room visits were assessed. Results The LAI group had a higher incidence of psychiatric acute ward admission (NLAI group = 4.8%; LAI = 30.3%) and emergency room visits (NLAI group = 7.3%; LAI group = 36.0%) before enrolment. During the one-year follow-up, the incidence of acute ward admission and emergency room visit did not differ in the NLAI group (P = .586 and .241) compared with before enrolment, whereas both incidences were significantly decreased in the LAI group (P < .0001 in both of them). Conclusions PLAI reduces the incidence of admission and emergency room visits.https://doi.org/10.1186/s12888-021-03513-7SchizophreniaLong-acting injectable antipsychoticsHospitalization incidenceEmergency servicePaliperidoneMirror study |
| spellingShingle | Hsue-Wei Chan Chin-Yu Huang Yung-Chieh Yen Clinical outcomes of paliperidone long-acting injection in patients with schizophrenia: a 1-year retrospective cohort study BMC Psychiatry Schizophrenia Long-acting injectable antipsychotics Hospitalization incidence Emergency service Paliperidone Mirror study |
| title | Clinical outcomes of paliperidone long-acting injection in patients with schizophrenia: a 1-year retrospective cohort study |
| title_full | Clinical outcomes of paliperidone long-acting injection in patients with schizophrenia: a 1-year retrospective cohort study |
| title_fullStr | Clinical outcomes of paliperidone long-acting injection in patients with schizophrenia: a 1-year retrospective cohort study |
| title_full_unstemmed | Clinical outcomes of paliperidone long-acting injection in patients with schizophrenia: a 1-year retrospective cohort study |
| title_short | Clinical outcomes of paliperidone long-acting injection in patients with schizophrenia: a 1-year retrospective cohort study |
| title_sort | clinical outcomes of paliperidone long acting injection in patients with schizophrenia a 1 year retrospective cohort study |
| topic | Schizophrenia Long-acting injectable antipsychotics Hospitalization incidence Emergency service Paliperidone Mirror study |
| url | https://doi.org/10.1186/s12888-021-03513-7 |
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