Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS)
Abstract Background To assess the impact of disease activity on health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE). Methods Cross-sectional study of patients included in the Swiss SLE Cohort Study between April 2007 and June 2014. HRQoL outcomes were based on the Medical Ou...
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| Format: | Article |
| Language: | English |
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BMC
2017-03-01
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| Series: | BMC Immunology |
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| Online Access: | http://link.springer.com/article/10.1186/s12865-017-0200-5 |
| _version_ | 1818991864181686272 |
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| author | Benjamin Chaigne Carlo Chizzolini Thomas Perneger Marten Trendelenburg Uyen Huynh-Do Eric Dayer Thomas Stoll Johannes von Kempis Camillo Ribi for the Swiss Systemic Lupus Erythematosus Cohort Study Group |
| author_facet | Benjamin Chaigne Carlo Chizzolini Thomas Perneger Marten Trendelenburg Uyen Huynh-Do Eric Dayer Thomas Stoll Johannes von Kempis Camillo Ribi for the Swiss Systemic Lupus Erythematosus Cohort Study Group |
| author_sort | Benjamin Chaigne |
| collection | DOAJ |
| description | Abstract Background To assess the impact of disease activity on health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE). Methods Cross-sectional study of patients included in the Swiss SLE Cohort Study between April 2007 and June 2014. HRQoL outcomes were based on the Medical Outcome Study Short Form 36 (SF-36). Disease activity was assessed by the SLE Disease Activity Index score with the Safety of Estrogens in SLE National Assessment modification (SELENA-SLEDAI) and by the physican’s global assessment (PGA). Results Of the 252 patients included, 207 (82%) were women. Median [interquartile range (IQR)] age was 43 [32–57] years. SLE was active in 125 patients (49.6%). Median [IQR] mental component summary (MCS) in active vs inactive SLE was 40.0 [30.2–51.0] compared to 47.3 [39.2–52.8] (p < 0.01) and median [IQR] physical component summary (PCS) 43.7 [37.0–52.8] compared to 49.1 [38.4–55.6], respectively (p < 0.05). Increase in SELENA-SLEDAI or increase in PGA were negatively correlated with PCS and/or MCS. After adjusting for gender, age and disease duration, disease activity impacted on both PCS and MCS and all subscales except general health. Active lupus nephritis and musculoskeletal involvement were associated with physical limitations and emotional problems, increased bodily pain and poor social functioning. Low complement and/or presence of anti-dsDNA antibodies were associated with increased fatigue and reduced mental health. Conclusions In patients with SLE, HRQoL is reduced in those with active disease. Impact of disease activity on HRQoL dimensions depends on SELENA-SLEDAI system components. |
| first_indexed | 2024-12-20T20:17:02Z |
| format | Article |
| id | doaj.art-969c7693b61e40e1840ce378479d3df4 |
| institution | Directory Open Access Journal |
| issn | 1471-2172 |
| language | English |
| last_indexed | 2024-12-20T20:17:02Z |
| publishDate | 2017-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj.art-969c7693b61e40e1840ce378479d3df42022-12-21T19:27:41ZengBMCBMC Immunology1471-21722017-03-011811910.1186/s12865-017-0200-5Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS)Benjamin Chaigne0Carlo Chizzolini1Thomas Perneger2Marten Trendelenburg3Uyen Huynh-Do4Eric Dayer5Thomas Stoll6Johannes von Kempis7Camillo Ribi8for the Swiss Systemic Lupus Erythematosus Cohort Study GroupDepartment of Internal Medicine Specialties, Clinical Immunology and Allergy, University Hospital and School of MedicineDepartment of Internal Medicine Specialties, Clinical Immunology and Allergy, University Hospital and School of MedicineDepartment of Community Health and Medicine, Clinical Epidemiology, University Hospital and School of MedicineDivision of Internal Medicine and Clinical Immunology Lab, Department of Biomedicine, University Hospital BaselNephrology, Hypertension and Clinical Pharmacology, University Hospital BernClinical Immunology and Allergy, Sion HospitalRheumatology, Kantonsspital SchaffhausenDivision of Rheumatology and Immunology, Department of Internal Medicine, Kantonsspital St GallenClinical Immunology and Allergy, University Hospital LausanneAbstract Background To assess the impact of disease activity on health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE). Methods Cross-sectional study of patients included in the Swiss SLE Cohort Study between April 2007 and June 2014. HRQoL outcomes were based on the Medical Outcome Study Short Form 36 (SF-36). Disease activity was assessed by the SLE Disease Activity Index score with the Safety of Estrogens in SLE National Assessment modification (SELENA-SLEDAI) and by the physican’s global assessment (PGA). Results Of the 252 patients included, 207 (82%) were women. Median [interquartile range (IQR)] age was 43 [32–57] years. SLE was active in 125 patients (49.6%). Median [IQR] mental component summary (MCS) in active vs inactive SLE was 40.0 [30.2–51.0] compared to 47.3 [39.2–52.8] (p < 0.01) and median [IQR] physical component summary (PCS) 43.7 [37.0–52.8] compared to 49.1 [38.4–55.6], respectively (p < 0.05). Increase in SELENA-SLEDAI or increase in PGA were negatively correlated with PCS and/or MCS. After adjusting for gender, age and disease duration, disease activity impacted on both PCS and MCS and all subscales except general health. Active lupus nephritis and musculoskeletal involvement were associated with physical limitations and emotional problems, increased bodily pain and poor social functioning. Low complement and/or presence of anti-dsDNA antibodies were associated with increased fatigue and reduced mental health. Conclusions In patients with SLE, HRQoL is reduced in those with active disease. Impact of disease activity on HRQoL dimensions depends on SELENA-SLEDAI system components.http://link.springer.com/article/10.1186/s12865-017-0200-5Systemic Lupus ErythematosusDisease activityDamageHealth-related quality of life |
| spellingShingle | Benjamin Chaigne Carlo Chizzolini Thomas Perneger Marten Trendelenburg Uyen Huynh-Do Eric Dayer Thomas Stoll Johannes von Kempis Camillo Ribi for the Swiss Systemic Lupus Erythematosus Cohort Study Group Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS) BMC Immunology Systemic Lupus Erythematosus Disease activity Damage Health-related quality of life |
| title | Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS) |
| title_full | Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS) |
| title_fullStr | Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS) |
| title_full_unstemmed | Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS) |
| title_short | Impact of disease activity on health-related quality of life in systemic lupus erythematosus – a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS) |
| title_sort | impact of disease activity on health related quality of life in systemic lupus erythematosus a cross sectional analysis of the swiss systemic lupus erythematosus cohort study sscs |
| topic | Systemic Lupus Erythematosus Disease activity Damage Health-related quality of life |
| url | http://link.springer.com/article/10.1186/s12865-017-0200-5 |
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