Probiotics’ Efficacy in Preventing Asthmatic Allergic Reaction Induced by Air Particles: An Animal Study
Global air pollution and diesel exhaust particles (DEPs) generated by intratracheal instillation aggravate asthma. In this study, we evaluated the effect of probiotics via tracheal- or oral-route administration on allergies or asthma. We continuously perfused rats daily, using the oral and tracheal...
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MDPI AG
2022-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/24/5219 |
| _version_ | 1797455951557558272 |
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| author | Chi-Yu Yang Fang-Yu Zhang I-Jen Wang |
| author_facet | Chi-Yu Yang Fang-Yu Zhang I-Jen Wang |
| author_sort | Chi-Yu Yang |
| collection | DOAJ |
| description | Global air pollution and diesel exhaust particles (DEPs) generated by intratracheal instillation aggravate asthma. In this study, we evaluated the effect of probiotics via tracheal- or oral-route administration on allergies or asthma. We continuously perfused rats daily, using the oral and tracheal routes, with approximately 10<sup>6</sup>–10<sup>8</sup> CFU probiotics, for 4 weeks. During this period, we used OVA-sensitized rats to build the asthma models. We orally or intratracheally administered <i>Lactobacillus paracasei</i> 33 (LP33) to the rats, which reduced the number of total inflammatory cells, lymphocytes, and eosinophils in the bronchoalveolar-lavage fluid, the IgE concentration, and the cytokine levels of TH2 cells, but we found no significant difference in the cytokine levels of TH1 cells. LP33 can be used to prevent asthmatic allergic reactions induced by aerosol particles. Nevertheless, the dosage form or use of LP33 needs to be adjusted to reduce the irritation of lung tissues, which may produce lesions of the trachea. We observed that DEP dosage can alleviate emphysema, and that LP33 has a substantial effect on improving or slowing allergic asthma. |
| first_indexed | 2024-03-09T16:00:30Z |
| format | Article |
| id | doaj.art-969e9bfffe0a4d41a6f89d06e31adbc4 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T16:00:30Z |
| publishDate | 2022-12-01 |
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| series | Nutrients |
| spelling | doaj.art-969e9bfffe0a4d41a6f89d06e31adbc42023-11-24T17:07:31ZengMDPI AGNutrients2072-66432022-12-011424521910.3390/nu14245219Probiotics’ Efficacy in Preventing Asthmatic Allergic Reaction Induced by Air Particles: An Animal StudyChi-Yu Yang0Fang-Yu Zhang1I-Jen Wang2Animal Technology Research Center, Agriculture Technology Research Institute, Miaoli 35053, TaiwanAnimal Technology Research Center, Agriculture Technology Research Institute, Miaoli 35053, TaiwanDepartment of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, Taipei 11267, TaiwanGlobal air pollution and diesel exhaust particles (DEPs) generated by intratracheal instillation aggravate asthma. In this study, we evaluated the effect of probiotics via tracheal- or oral-route administration on allergies or asthma. We continuously perfused rats daily, using the oral and tracheal routes, with approximately 10<sup>6</sup>–10<sup>8</sup> CFU probiotics, for 4 weeks. During this period, we used OVA-sensitized rats to build the asthma models. We orally or intratracheally administered <i>Lactobacillus paracasei</i> 33 (LP33) to the rats, which reduced the number of total inflammatory cells, lymphocytes, and eosinophils in the bronchoalveolar-lavage fluid, the IgE concentration, and the cytokine levels of TH2 cells, but we found no significant difference in the cytokine levels of TH1 cells. LP33 can be used to prevent asthmatic allergic reactions induced by aerosol particles. Nevertheless, the dosage form or use of LP33 needs to be adjusted to reduce the irritation of lung tissues, which may produce lesions of the trachea. We observed that DEP dosage can alleviate emphysema, and that LP33 has a substantial effect on improving or slowing allergic asthma.https://www.mdpi.com/2072-6643/14/24/5219diesel exhaust particlesasthmaovalbuminprobioticsallergic disease |
| spellingShingle | Chi-Yu Yang Fang-Yu Zhang I-Jen Wang Probiotics’ Efficacy in Preventing Asthmatic Allergic Reaction Induced by Air Particles: An Animal Study Nutrients diesel exhaust particles asthma ovalbumin probiotics allergic disease |
| title | Probiotics’ Efficacy in Preventing Asthmatic Allergic Reaction Induced by Air Particles: An Animal Study |
| title_full | Probiotics’ Efficacy in Preventing Asthmatic Allergic Reaction Induced by Air Particles: An Animal Study |
| title_fullStr | Probiotics’ Efficacy in Preventing Asthmatic Allergic Reaction Induced by Air Particles: An Animal Study |
| title_full_unstemmed | Probiotics’ Efficacy in Preventing Asthmatic Allergic Reaction Induced by Air Particles: An Animal Study |
| title_short | Probiotics’ Efficacy in Preventing Asthmatic Allergic Reaction Induced by Air Particles: An Animal Study |
| title_sort | probiotics efficacy in preventing asthmatic allergic reaction induced by air particles an animal study |
| topic | diesel exhaust particles asthma ovalbumin probiotics allergic disease |
| url | https://www.mdpi.com/2072-6643/14/24/5219 |
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