Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease
As of 2022, the prevalence of Alzheimer’s disease (AD) among individuals aged 65 and older is estimated to be 6.2 million in the United States. This figure is predicted to grow to 13.8 million by 2060. An accurate assessment of neuropathologic changes represents a critical step in understanding the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Neurology International |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2035-8377/15/3/54 |
| _version_ | 1797578402777006080 |
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| author | Nicholas Doher Vahid Davoudi Shino Magaki Ryan A. Townley Mohammad Haeri Harry V. Vinters |
| author_facet | Nicholas Doher Vahid Davoudi Shino Magaki Ryan A. Townley Mohammad Haeri Harry V. Vinters |
| author_sort | Nicholas Doher |
| collection | DOAJ |
| description | As of 2022, the prevalence of Alzheimer’s disease (AD) among individuals aged 65 and older is estimated to be 6.2 million in the United States. This figure is predicted to grow to 13.8 million by 2060. An accurate assessment of neuropathologic changes represents a critical step in understanding the underlying mechanisms in AD. The current method for assessing postmortem Alzheimer’s disease neuropathologic change follows version 11 of the National Alzheimer’s Coordinating Center (NACC) coding guidebook. Ambiguity regarding steps in the ABC scoring method can lead to increased time or inaccuracy in staging AD. We present a concise overview of how this postmortem diagnosis is made and relate it to the evolving understanding of antemortem AD biomarkers. |
| first_indexed | 2024-03-10T22:21:27Z |
| format | Article |
| id | doaj.art-969fb583e6ea4a1f9527f031a0e9adc5 |
| institution | Directory Open Access Journal |
| issn | 2035-8377 |
| language | English |
| last_indexed | 2024-03-10T22:21:27Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj.art-969fb583e6ea4a1f9527f031a0e9adc52023-11-19T12:15:45ZengMDPI AGNeurology International2035-83772023-07-0115385786710.3390/neurolint15030054Illustrated Neuropathologic Diagnosis of Alzheimer’s DiseaseNicholas Doher0Vahid Davoudi1Shino Magaki2Ryan A. Townley3Mohammad Haeri4Harry V. Vinters5Department of Neurology, University of Florida, Gainesville, FL 32611, USADepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USADepartment of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USADepartment of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USADepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USADepartment of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USAAs of 2022, the prevalence of Alzheimer’s disease (AD) among individuals aged 65 and older is estimated to be 6.2 million in the United States. This figure is predicted to grow to 13.8 million by 2060. An accurate assessment of neuropathologic changes represents a critical step in understanding the underlying mechanisms in AD. The current method for assessing postmortem Alzheimer’s disease neuropathologic change follows version 11 of the National Alzheimer’s Coordinating Center (NACC) coding guidebook. Ambiguity regarding steps in the ABC scoring method can lead to increased time or inaccuracy in staging AD. We present a concise overview of how this postmortem diagnosis is made and relate it to the evolving understanding of antemortem AD biomarkers.https://www.mdpi.com/2035-8377/15/3/54Alzheimer’s diseaseneurodegenerationtauopathydementiaAD neuropathologic diagnosis |
| spellingShingle | Nicholas Doher Vahid Davoudi Shino Magaki Ryan A. Townley Mohammad Haeri Harry V. Vinters Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease Neurology International Alzheimer’s disease neurodegeneration tauopathy dementia AD neuropathologic diagnosis |
| title | Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease |
| title_full | Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease |
| title_fullStr | Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease |
| title_full_unstemmed | Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease |
| title_short | Illustrated Neuropathologic Diagnosis of Alzheimer’s Disease |
| title_sort | illustrated neuropathologic diagnosis of alzheimer s disease |
| topic | Alzheimer’s disease neurodegeneration tauopathy dementia AD neuropathologic diagnosis |
| url | https://www.mdpi.com/2035-8377/15/3/54 |
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