New Diarylamine K<sub>V</sub>10.1 Inhibitors and Their Anticancer Potential

New Diarylamine K<sub>V</sub>10.1 Inhibitors and Their Anticancer Potential

Expression of the voltage-gated potassium channel K<sub>V</sub>10.1 (Eag1) has been detected in over 70% of human cancers, making the channel a promising new target for new anticancer drug discovery. A new structural class of K<sub>V</sub>10.1 inhibitors was prepared by struc...

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Bibliographic Details
Main Authors: Špela Gubič, Žan Toplak, Xiaoyi Shi, Jaka Dernovšek, Louise Antonia Hendrickx, Ernesto Lopes Pinheiro-Junior, Steve Peigneur, Jan Tytgat, Luis A. Pardo, Lucija Peterlin Mašič, Tihomir Tomašič
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceutics
Subjects:
K<sub>V</sub>10.1
ion channels
hERG
SAR
antiproliferative activity
Online Access:https://www.mdpi.com/1999-4923/14/9/1963

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https://www.mdpi.com/1999-4923/14/9/1963

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