New Diarylamine K<sub>V</sub>10.1 Inhibitors and Their Anticancer Potential
Expression of the voltage-gated potassium channel K<sub>V</sub>10.1 (Eag1) has been detected in over 70% of human cancers, making the channel a promising new target for new anticancer drug discovery. A new structural class of K<sub>V</sub>10.1 inhibitors was prepared by struc...
Main Authors: | Špela Gubič, Žan Toplak, Xiaoyi Shi, Jaka Dernovšek, Louise Antonia Hendrickx, Ernesto Lopes Pinheiro-Junior, Steve Peigneur, Jan Tytgat, Luis A. Pardo, Lucija Peterlin Mašič, Tihomir Tomašič |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-09-01
|
Series: | Pharmaceutics |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4923/14/9/1963 |
Similar Items
-
3D Pharmacophore-Based Discovery of Novel K<sub>V</sub>10.1 Inhibitors with Antiproliferative Activity
by: Žan Toplak, et al.
Published: (2021-03-01) -
Molecular Dynamics-Derived Pharmacophore Model Explaining the Nonselective Aspect of K<sub>V</sub>10.1 Pore Blockers
by: Žan Toplak, et al.
Published: (2021-08-01) -
Design of New Potent and Selective Thiophene-Based K<sub>V</sub>1.3 Inhibitors and Their Potential for Anticancer Activity
by: Špela Gubič, et al.
Published: (2022-05-01) -
Molecular mechanisms underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells
by: Takeshi Onohara, MD, et al.
Published: (2017-06-01) -
Evaluation of Some Safety Parameters of Dual Histamine H<sub>3</sub> and Sigma-2 Receptor Ligands with Anti-Obesity Potential
by: Kamil Mika, et al.
Published: (2023-04-01)