The Comparative Genomics and Phylogenomics of Parasite
Leishmaniasis is an infectious disease caused by Leishmania species. Leishmania amazonensis is a New World Leishmania species belonging to the Mexicana complex, which is able to cause all types of leishmaniasis infections. The L. amazonensis reference strain MHOM/BR/1973/M2269 was sequenced identify...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2014-01-01
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| Series: | Evolutionary Bioinformatics |
| Online Access: | https://doi.org/10.4137/EBO.S13759 |
| _version_ | 1819048351226658816 |
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| author | Diogo A. Tschoeke Gisele L. Nunes Rodrigo Jardim Joana Lima Aline S. R. Dumaresq Monete R. Gomes Leandro De Mattos Pereira Daniel R. Loureiro Patricia H. Stoco Herbert Leonel De Matos Gliedes Antonio Basilio De Miranda Jeronimo Ruiz André Pitaluga Floriano P. Silva Christian M. Probst Nicholas J. Dickens Jeremy C. Mottram Edmundo C. Grisard Alberto M. R. Dávila |
| author_facet | Diogo A. Tschoeke Gisele L. Nunes Rodrigo Jardim Joana Lima Aline S. R. Dumaresq Monete R. Gomes Leandro De Mattos Pereira Daniel R. Loureiro Patricia H. Stoco Herbert Leonel De Matos Gliedes Antonio Basilio De Miranda Jeronimo Ruiz André Pitaluga Floriano P. Silva Christian M. Probst Nicholas J. Dickens Jeremy C. Mottram Edmundo C. Grisard Alberto M. R. Dávila |
| author_sort | Diogo A. Tschoeke |
| collection | DOAJ |
| description | Leishmaniasis is an infectious disease caused by Leishmania species. Leishmania amazonensis is a New World Leishmania species belonging to the Mexicana complex, which is able to cause all types of leishmaniasis infections. The L. amazonensis reference strain MHOM/BR/1973/M2269 was sequenced identifying 8,802 codifying sequences (CDS), most of them of hypothetical function. Comparative analysis using six Leishmania species showed a core set of 7,016 orthologs. L. amazonensis and Leishmania mexicana share the largest number of distinct orthologs, while Leishmania braziliensis presented the largest number of inparalogs. Additionally, phylogenomic analysis confirmed the taxonomic position for L. amazonensis within the “Mexicana complex”, reinforcing understanding of the split of New and Old World Leishmania. Potential non-homologous isofunctional enzymes (NISE) were identified between L. amazonensis and Homo sapiens that could provide new drug targets for development. |
| first_indexed | 2024-12-21T11:14:52Z |
| format | Article |
| id | doaj.art-96a3594ef0f64c1aae6748df3814de9e |
| institution | Directory Open Access Journal |
| issn | 1176-9343 |
| language | English |
| last_indexed | 2024-12-21T11:14:52Z |
| publishDate | 2014-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Evolutionary Bioinformatics |
| spelling | doaj.art-96a3594ef0f64c1aae6748df3814de9e2022-12-21T19:05:58ZengSAGE PublishingEvolutionary Bioinformatics1176-93432014-01-011010.4137/EBO.S13759The Comparative Genomics and Phylogenomics of ParasiteDiogo A. Tschoeke0Gisele L. Nunes1Rodrigo Jardim2Joana Lima3Aline S. R. Dumaresq4Monete R. Gomes5Leandro De Mattos Pereira6Daniel R. Loureiro7Patricia H. Stoco8Herbert Leonel De Matos Gliedes9Antonio Basilio De Miranda10Jeronimo Ruiz11André Pitaluga12Floriano P. Silva13Christian M. Probst14Nicholas J. Dickens15Jeremy C. Mottram16Edmundo C. Grisard17Alberto M. R. Dávila18Laboratório de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.Laboratório de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.Laboratório de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.Laboratório de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.Laboratório de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.Laboratório de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.Laboratório de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.Pólo de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz (Fiocruz/IOC), Rio de Janeiro, RJ, Brazil.Laboratório de Protozoologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.Wellcome Trust Centre for Molecular Parasitology, Institute of Immunity, Infection and Inflammation, College of MVLS, University of Glasgow, Glasgow, UK.Laboratório de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.Instituto René Rachou (Fiocruz/IRR), Belo Horizonte, MG, Brazil.Laboratório de Biologia Molecular de Parasitas e Vetores, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.Laboratório de Bioquímica de Proteínas e Peptídeos, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.Instituto Carlos Chagas (Fiocruz/ICC), Curitiba, PR, Brazil.Wellcome Trust Centre for Molecular Parasitology, Institute of Immunity, Infection and Inflammation, College of MVLS, University of Glasgow, Glasgow, UK.Wellcome Trust Centre for Molecular Parasitology, Institute of Immunity, Infection and Inflammation, College of MVLS, University of Glasgow, Glasgow, UK.Laboratório de Protozoologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.Laboratório de Biologia Computacional e Sistemas, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil.Leishmaniasis is an infectious disease caused by Leishmania species. Leishmania amazonensis is a New World Leishmania species belonging to the Mexicana complex, which is able to cause all types of leishmaniasis infections. The L. amazonensis reference strain MHOM/BR/1973/M2269 was sequenced identifying 8,802 codifying sequences (CDS), most of them of hypothetical function. Comparative analysis using six Leishmania species showed a core set of 7,016 orthologs. L. amazonensis and Leishmania mexicana share the largest number of distinct orthologs, while Leishmania braziliensis presented the largest number of inparalogs. Additionally, phylogenomic analysis confirmed the taxonomic position for L. amazonensis within the “Mexicana complex”, reinforcing understanding of the split of New and Old World Leishmania. Potential non-homologous isofunctional enzymes (NISE) were identified between L. amazonensis and Homo sapiens that could provide new drug targets for development.https://doi.org/10.4137/EBO.S13759 |
| spellingShingle | Diogo A. Tschoeke Gisele L. Nunes Rodrigo Jardim Joana Lima Aline S. R. Dumaresq Monete R. Gomes Leandro De Mattos Pereira Daniel R. Loureiro Patricia H. Stoco Herbert Leonel De Matos Gliedes Antonio Basilio De Miranda Jeronimo Ruiz André Pitaluga Floriano P. Silva Christian M. Probst Nicholas J. Dickens Jeremy C. Mottram Edmundo C. Grisard Alberto M. R. Dávila The Comparative Genomics and Phylogenomics of Parasite Evolutionary Bioinformatics |
| title | The Comparative Genomics and Phylogenomics of Parasite |
| title_full | The Comparative Genomics and Phylogenomics of Parasite |
| title_fullStr | The Comparative Genomics and Phylogenomics of Parasite |
| title_full_unstemmed | The Comparative Genomics and Phylogenomics of Parasite |
| title_short | The Comparative Genomics and Phylogenomics of Parasite |
| title_sort | comparative genomics and phylogenomics of parasite |
| url | https://doi.org/10.4137/EBO.S13759 |
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