Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D
Background: The initial inflammatory reaction starts following occlusion in ischemic stroke (IS). Interleukin-1β (IL-1β) is a pro-inflammatory cytokine with a crucial role in the pathogenesis of neurodegenerative disorders.Objective: To investigate the levels of IL-1β and vitamin D (VitD) in patient...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2023-09-01
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| Series: | Iranian Journal of Immunology |
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| Online Access: | https://iji.sums.ac.ir/article_49407_056be50850d45f4dc65a8de0d0638c1f.pdf |
| _version_ | 1797680505179602944 |
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| author | Mahnaz Bayat Niloufar Razavi Moosavi Najmeh Karimi Moosa Rahimi Afshin Borhani-Haghighi |
| author_facet | Mahnaz Bayat Niloufar Razavi Moosavi Najmeh Karimi Moosa Rahimi Afshin Borhani-Haghighi |
| author_sort | Mahnaz Bayat |
| collection | DOAJ |
| description | Background: The initial inflammatory reaction starts following occlusion in ischemic stroke (IS). Interleukin-1β (IL-1β) is a pro-inflammatory cytokine with a crucial role in the pathogenesis of neurodegenerative disorders.Objective: To investigate the levels of IL-1β and vitamin D (VitD) in patients with IS compared with controls and their correlation.Methods: The serum level of 25-OH VitD and IL-1β was assessed in 102 IS patients (0-24 h after stroke) and 102 controls with an enzyme-linked immunosorbent assay (ELISA) kit.Results: We found a significant increase in IL-1β (80.14±6.8 vs. 60.32±4.1 pg/ml, p<0.05) and a decrease in VitD level (24.3±1.4 vs. 29.9±1.5 ng/ml, p<0.01) in the IS patients compared with the controls. There was a significantly positive correlation between the National Institutes of Health Stroke Scale (NIHSS) and IL-1β according to both the Spearman correlation (r=0.35, p=0.0003) and the linear regression (beta=0.255, p=0.014). Also, a significant negative association between VitD and NIHSS was detected by the Spearman correlation (r=-0.41, p<0.0001) and the linear regression (beta=-0.381, p=0.000). Moreover, we found a significant negative correlation (r=-0.26, p=0.006) between the serum levels of VitD and IL-1β in the patient group.Conclusion: Ischemic stroke correlates positively with IL-1β and negatively with VitD levels. The speculated role of VitD deficiency in the evolution and severity of stroke may be justified by its role in the modification of inflammation. |
| first_indexed | 2024-03-11T23:30:58Z |
| format | Article |
| id | doaj.art-96a4e4652f3f468da61d3ac8a226dbf9 |
| institution | Directory Open Access Journal |
| issn | 1735-1383 1735-367X |
| language | English |
| last_indexed | 2024-03-11T23:30:58Z |
| publishDate | 2023-09-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Immunology |
| spelling | doaj.art-96a4e4652f3f468da61d3ac8a226dbf92023-09-20T09:13:41ZengShiraz University of Medical SciencesIranian Journal of Immunology1735-13831735-367X2023-09-0120335936710.22034/iji.2023.96384.243249407Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin DMahnaz Bayat0Niloufar Razavi Moosavi1Najmeh Karimi2Moosa Rahimi3Afshin Borhani-Haghighi4Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Laboratory of Basic Sciences, Mohammad Rasul Allah Research Tower, Shiraz University of Medical Sciences, Shiraz, Iran.Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.Background: The initial inflammatory reaction starts following occlusion in ischemic stroke (IS). Interleukin-1β (IL-1β) is a pro-inflammatory cytokine with a crucial role in the pathogenesis of neurodegenerative disorders.Objective: To investigate the levels of IL-1β and vitamin D (VitD) in patients with IS compared with controls and their correlation.Methods: The serum level of 25-OH VitD and IL-1β was assessed in 102 IS patients (0-24 h after stroke) and 102 controls with an enzyme-linked immunosorbent assay (ELISA) kit.Results: We found a significant increase in IL-1β (80.14±6.8 vs. 60.32±4.1 pg/ml, p<0.05) and a decrease in VitD level (24.3±1.4 vs. 29.9±1.5 ng/ml, p<0.01) in the IS patients compared with the controls. There was a significantly positive correlation between the National Institutes of Health Stroke Scale (NIHSS) and IL-1β according to both the Spearman correlation (r=0.35, p=0.0003) and the linear regression (beta=0.255, p=0.014). Also, a significant negative association between VitD and NIHSS was detected by the Spearman correlation (r=-0.41, p<0.0001) and the linear regression (beta=-0.381, p=0.000). Moreover, we found a significant negative correlation (r=-0.26, p=0.006) between the serum levels of VitD and IL-1β in the patient group.Conclusion: Ischemic stroke correlates positively with IL-1β and negatively with VitD levels. The speculated role of VitD deficiency in the evolution and severity of stroke may be justified by its role in the modification of inflammation.https://iji.sums.ac.ir/article_49407_056be50850d45f4dc65a8de0d0638c1f.pdfinflammationinterleukin-1βischemic strokevitamin d |
| spellingShingle | Mahnaz Bayat Niloufar Razavi Moosavi Najmeh Karimi Moosa Rahimi Afshin Borhani-Haghighi Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D Iranian Journal of Immunology inflammation interleukin-1β ischemic stroke vitamin d |
| title | Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D |
| title_full | Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D |
| title_fullStr | Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D |
| title_full_unstemmed | Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D |
| title_short | Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D |
| title_sort | increased serum levels of il 1β after ischemic stroke are inversely associated with vitamin d |
| topic | inflammation interleukin-1β ischemic stroke vitamin d |
| url | https://iji.sums.ac.ir/article_49407_056be50850d45f4dc65a8de0d0638c1f.pdf |
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