Incidence and Risk Factors for Hypoxia in Deep Sedation of Propofol for Artificial Abortion Patients
BackgroundRespiratory depression is a life-threatening adverse effect of deep sedation. This study aimed to investigate the factors related to hypoxia caused by propofol during intravenous anesthesia.MethodsThree hundred and eight patients who underwent painless artificial abortion in the outpatient...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.763275/full |
| _version_ | 1817990989680214016 |
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| author | Yiling Fang Yiling Fang Yiling Fang Yiling Fang Yiling Fang Yaru Xu Silu Cao Xiaoru Sun Xiaoru Sun Xiaoru Sun Hui Zhang Qi Jing Li Tian Li Tian Li Tian Cheng Li Cheng Li Cheng Li |
| author_facet | Yiling Fang Yiling Fang Yiling Fang Yiling Fang Yiling Fang Yaru Xu Silu Cao Xiaoru Sun Xiaoru Sun Xiaoru Sun Hui Zhang Qi Jing Li Tian Li Tian Li Tian Cheng Li Cheng Li Cheng Li |
| author_sort | Yiling Fang |
| collection | DOAJ |
| description | BackgroundRespiratory depression is a life-threatening adverse effect of deep sedation. This study aimed to investigate the factors related to hypoxia caused by propofol during intravenous anesthesia.MethodsThree hundred and eight patients who underwent painless artificial abortion in the outpatient department of Shanghai Tenth People’s Hospital between November 1, 2019 and June 30, 2020 were divided into two groups according to whether the patients experienced hypoxia (SpO2 < 95%). Preoperative anxiety assessments, anesthesia process, and operation-related information of the two groups were analyzed. The univariate analysis results were further incorporated into logistic regression analysis for multivariate analysis to determine the independent risk factors affecting hypoxia.ResultsUnivariate analysis revealed that body mass index (BMI) (21.80 ± 2.94 vs. 21.01 ± 2.39; P = 0.038, 95% confidence interval (CI) = [−1.54, −0.04]), propofol dose (15.83 ± 3.21 vs. 14.39 ± 3.01; P = 0.002, CI = [−2.34, −0.53]), menopausal days (49.64 ± 6.03 vs. 52.14 ± 5.73; P = 0.004, CI = [0.79, 4.21]), State Anxiety Inventory score (51.19 ± 7.55 vs. 44.49 ± 8.96; P < 0.001, CI = [−9.26, −4.15]), and Self-rating Anxiety Scale score (45.86 ± 9.48 vs. 42.45 ± 9.88; P = 0.021, CI = [−6.30, −0.53]) were statistically significant risk factors for hypoxia during the operation. Logistic regression analysis showed that propofol dosage, menopausal days, and State Anxiety Inventory score were independent risk factors for hypoxia.ConclusionPatient anxiety affects the incidence of hypoxia when undergoing deep intravenous anesthesia with propofol. We can further speculate that alleviating patient anxiety can reduce the incidence of hypoxia.Clinical Trial Registration[http://www.chictr.org.cn], identifier [ChiCTR2000032167]. |
| first_indexed | 2024-04-14T01:07:27Z |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-14T01:07:27Z |
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| spelling | doaj.art-96a5cadd80f9426aab294e7713fb874d2022-12-22T02:21:11ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-04-01910.3389/fmed.2022.763275763275Incidence and Risk Factors for Hypoxia in Deep Sedation of Propofol for Artificial Abortion PatientsYiling Fang0Yiling Fang1Yiling Fang2Yiling Fang3Yiling Fang4Yaru Xu5Silu Cao6Xiaoru Sun7Xiaoru Sun8Xiaoru Sun9Hui Zhang10Qi Jing11Li Tian12Li Tian13Li Tian14Cheng Li15Cheng Li16Cheng Li17Department of Anesthesiology and Perioperative Medicine, School of Medicine, Shanghai Fourth People’s Hospital, Tongji University, Shanghai, ChinaSchool of Medicine, Shanghai Fourth People’s Hospital, Translational Research Institute of Brain and Brain-Like Intelligence, Tongji University, Shanghai, ChinaClinical Research Center for Anesthesiology and Perioperative Medicine, Tongji University, Shanghai, ChinaDepartment of Anesthesiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of General Practice, Zhangjiagang First People’s Hospital, Affiliated to Soochow University School of Medicine, Zhangjiagang, ChinaDepartment of Anesthesiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, Shanghai Fourth People’s Hospital, Tongji University, Shanghai, ChinaSchool of Medicine, Shanghai Fourth People’s Hospital, Translational Research Institute of Brain and Brain-Like Intelligence, Tongji University, Shanghai, ChinaClinical Research Center for Anesthesiology and Perioperative Medicine, Tongji University, Shanghai, ChinaDepartment of Anesthesiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Anesthesiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, Shanghai Fourth People’s Hospital, Tongji University, Shanghai, ChinaSchool of Medicine, Shanghai Fourth People’s Hospital, Translational Research Institute of Brain and Brain-Like Intelligence, Tongji University, Shanghai, ChinaClinical Research Center for Anesthesiology and Perioperative Medicine, Tongji University, Shanghai, ChinaDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, Shanghai Fourth People’s Hospital, Tongji University, Shanghai, ChinaSchool of Medicine, Shanghai Fourth People’s Hospital, Translational Research Institute of Brain and Brain-Like Intelligence, Tongji University, Shanghai, ChinaClinical Research Center for Anesthesiology and Perioperative Medicine, Tongji University, Shanghai, ChinaBackgroundRespiratory depression is a life-threatening adverse effect of deep sedation. This study aimed to investigate the factors related to hypoxia caused by propofol during intravenous anesthesia.MethodsThree hundred and eight patients who underwent painless artificial abortion in the outpatient department of Shanghai Tenth People’s Hospital between November 1, 2019 and June 30, 2020 were divided into two groups according to whether the patients experienced hypoxia (SpO2 < 95%). Preoperative anxiety assessments, anesthesia process, and operation-related information of the two groups were analyzed. The univariate analysis results were further incorporated into logistic regression analysis for multivariate analysis to determine the independent risk factors affecting hypoxia.ResultsUnivariate analysis revealed that body mass index (BMI) (21.80 ± 2.94 vs. 21.01 ± 2.39; P = 0.038, 95% confidence interval (CI) = [−1.54, −0.04]), propofol dose (15.83 ± 3.21 vs. 14.39 ± 3.01; P = 0.002, CI = [−2.34, −0.53]), menopausal days (49.64 ± 6.03 vs. 52.14 ± 5.73; P = 0.004, CI = [0.79, 4.21]), State Anxiety Inventory score (51.19 ± 7.55 vs. 44.49 ± 8.96; P < 0.001, CI = [−9.26, −4.15]), and Self-rating Anxiety Scale score (45.86 ± 9.48 vs. 42.45 ± 9.88; P = 0.021, CI = [−6.30, −0.53]) were statistically significant risk factors for hypoxia during the operation. Logistic regression analysis showed that propofol dosage, menopausal days, and State Anxiety Inventory score were independent risk factors for hypoxia.ConclusionPatient anxiety affects the incidence of hypoxia when undergoing deep intravenous anesthesia with propofol. We can further speculate that alleviating patient anxiety can reduce the incidence of hypoxia.Clinical Trial Registration[http://www.chictr.org.cn], identifier [ChiCTR2000032167].https://www.frontiersin.org/articles/10.3389/fmed.2022.763275/fulldeep sedationpropofol anesthesiahypoxiapatient anxietypainless artificial abortion |
| spellingShingle | Yiling Fang Yiling Fang Yiling Fang Yiling Fang Yiling Fang Yaru Xu Silu Cao Xiaoru Sun Xiaoru Sun Xiaoru Sun Hui Zhang Qi Jing Li Tian Li Tian Li Tian Cheng Li Cheng Li Cheng Li Incidence and Risk Factors for Hypoxia in Deep Sedation of Propofol for Artificial Abortion Patients Frontiers in Medicine deep sedation propofol anesthesia hypoxia patient anxiety painless artificial abortion |
| title | Incidence and Risk Factors for Hypoxia in Deep Sedation of Propofol for Artificial Abortion Patients |
| title_full | Incidence and Risk Factors for Hypoxia in Deep Sedation of Propofol for Artificial Abortion Patients |
| title_fullStr | Incidence and Risk Factors for Hypoxia in Deep Sedation of Propofol for Artificial Abortion Patients |
| title_full_unstemmed | Incidence and Risk Factors for Hypoxia in Deep Sedation of Propofol for Artificial Abortion Patients |
| title_short | Incidence and Risk Factors for Hypoxia in Deep Sedation of Propofol for Artificial Abortion Patients |
| title_sort | incidence and risk factors for hypoxia in deep sedation of propofol for artificial abortion patients |
| topic | deep sedation propofol anesthesia hypoxia patient anxiety painless artificial abortion |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.763275/full |
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