Changes in Gray Matter Asymmetries of the Fusiform and Parahippocampal Gyruses in Patients With Subcortical Ischemic Vascular Disease
Objective: Changes in the normal asymmetry of the human brain often mean pathology. Current studies on the correlation between asymmetry and cognitive impairment have focused on Alzheimer's disease (AD) and AD-related mild cognitive impairment (MCI). The purpose of this study was to investigate...
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2020.603977/full |
| _version_ | 1828968673686061056 |
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| author | Runtian Cheng Li Chen Xiaoshuang Liu Tianyou Luo Junwei Gong Peiling Jiang |
| author_facet | Runtian Cheng Li Chen Xiaoshuang Liu Tianyou Luo Junwei Gong Peiling Jiang |
| author_sort | Runtian Cheng |
| collection | DOAJ |
| description | Objective: Changes in the normal asymmetry of the human brain often mean pathology. Current studies on the correlation between asymmetry and cognitive impairment have focused on Alzheimer's disease (AD) and AD-related mild cognitive impairment (MCI). The purpose of this study was to investigate changes in gray matter asymmetry and their relationship with cognitive impairment in patients with subcortical ischemic vascular disease (SIVD) by using voxel-based morphological measurements.Methods: Fifty-nine SIVD patients with (subcortical vascular cognitive impairment, SVCI, N = 30) and without (pre-SVCI, N = 29) cognitive impairment and 30 normal controls (NC, N = 30) underwent high-resolution structural MRI and neuropsychological examinations. The differences in gray matter asymmetry among the three groups were estimated by using one-way ANOVA. Moreover, partial correlation analysis was performed to explore the relationships between the asymmetry index (AI) values and cognitive assessments controlled for age, sex, and education.Results: The gray matter asymmetries in the fusiform and parahippocampal gyruses of the SVCI group were significantly different from those of the NC group and the pre-SVCI group, while no differences were found between the NC group and the pre-SVCI group in the same areas. More specifically, in the fusiform and parahippocampal gyruses, the SVCI group displayed a dramatic rightward asymmetry, whereas the NC group and pre-SVCI group exhibited a marked leftward asymmetry. The results of the correlation analysis showed that the “mean AI” in significant cluster was strongly correlated with the changes in cognitive outcomes.Conclusion: This study demonstrated different lateralization in the fusiform and parahippocampal gyruses of SIVD patients with cognitive impairment compared to healthy subjects and SIVD patients without cognitive decline. Our findings may contribute to better understanding the possible mechanism of cognitive impairment in patients with SIVD, and they suggest the possibility of using gray matter asymmetry as a biomarker for disease progression. |
| first_indexed | 2024-12-14T12:16:30Z |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-14T12:16:30Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-96a7acb09d064b58918a1f4b62f64c5b2022-12-21T23:01:38ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-01-011110.3389/fneur.2020.603977603977Changes in Gray Matter Asymmetries of the Fusiform and Parahippocampal Gyruses in Patients With Subcortical Ischemic Vascular DiseaseRuntian Cheng0Li Chen1Xiaoshuang Liu2Tianyou Luo3Junwei Gong4Peiling Jiang5The Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaThe Department of Radiology, The Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaThe Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaThe Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaThe Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaThe Department of Radiology, The Second Affiliated Hospital of Military Medical University, Chongqing, ChinaObjective: Changes in the normal asymmetry of the human brain often mean pathology. Current studies on the correlation between asymmetry and cognitive impairment have focused on Alzheimer's disease (AD) and AD-related mild cognitive impairment (MCI). The purpose of this study was to investigate changes in gray matter asymmetry and their relationship with cognitive impairment in patients with subcortical ischemic vascular disease (SIVD) by using voxel-based morphological measurements.Methods: Fifty-nine SIVD patients with (subcortical vascular cognitive impairment, SVCI, N = 30) and without (pre-SVCI, N = 29) cognitive impairment and 30 normal controls (NC, N = 30) underwent high-resolution structural MRI and neuropsychological examinations. The differences in gray matter asymmetry among the three groups were estimated by using one-way ANOVA. Moreover, partial correlation analysis was performed to explore the relationships between the asymmetry index (AI) values and cognitive assessments controlled for age, sex, and education.Results: The gray matter asymmetries in the fusiform and parahippocampal gyruses of the SVCI group were significantly different from those of the NC group and the pre-SVCI group, while no differences were found between the NC group and the pre-SVCI group in the same areas. More specifically, in the fusiform and parahippocampal gyruses, the SVCI group displayed a dramatic rightward asymmetry, whereas the NC group and pre-SVCI group exhibited a marked leftward asymmetry. The results of the correlation analysis showed that the “mean AI” in significant cluster was strongly correlated with the changes in cognitive outcomes.Conclusion: This study demonstrated different lateralization in the fusiform and parahippocampal gyruses of SIVD patients with cognitive impairment compared to healthy subjects and SIVD patients without cognitive decline. Our findings may contribute to better understanding the possible mechanism of cognitive impairment in patients with SIVD, and they suggest the possibility of using gray matter asymmetry as a biomarker for disease progression.https://www.frontiersin.org/articles/10.3389/fneur.2020.603977/fullsubcortical ischemic vascular diseasevascular cognitive impairmentgray matter asymmetryMRIvoxel-based morphometry |
| spellingShingle | Runtian Cheng Li Chen Xiaoshuang Liu Tianyou Luo Junwei Gong Peiling Jiang Changes in Gray Matter Asymmetries of the Fusiform and Parahippocampal Gyruses in Patients With Subcortical Ischemic Vascular Disease Frontiers in Neurology subcortical ischemic vascular disease vascular cognitive impairment gray matter asymmetry MRI voxel-based morphometry |
| title | Changes in Gray Matter Asymmetries of the Fusiform and Parahippocampal Gyruses in Patients With Subcortical Ischemic Vascular Disease |
| title_full | Changes in Gray Matter Asymmetries of the Fusiform and Parahippocampal Gyruses in Patients With Subcortical Ischemic Vascular Disease |
| title_fullStr | Changes in Gray Matter Asymmetries of the Fusiform and Parahippocampal Gyruses in Patients With Subcortical Ischemic Vascular Disease |
| title_full_unstemmed | Changes in Gray Matter Asymmetries of the Fusiform and Parahippocampal Gyruses in Patients With Subcortical Ischemic Vascular Disease |
| title_short | Changes in Gray Matter Asymmetries of the Fusiform and Parahippocampal Gyruses in Patients With Subcortical Ischemic Vascular Disease |
| title_sort | changes in gray matter asymmetries of the fusiform and parahippocampal gyruses in patients with subcortical ischemic vascular disease |
| topic | subcortical ischemic vascular disease vascular cognitive impairment gray matter asymmetry MRI voxel-based morphometry |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2020.603977/full |
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