Global transcriptomic profiling of microcystin-LR or -RR treated hepatocytes (HepaRG)

Global transcriptomic profiling of microcystin-LR or -RR treated hepatocytes (HepaRG)

The canonical mode of action (MOA) of microcystins (MC) is the inhibition of protein phosphatases, but complete characterization of toxicity pathways is lacking. The existence of over 200 MC congeners complicates risk estimates worldwide. This work employed RNA-seq to provide an unbiased and compreh...

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Bibliographic Details
Main Authors: Adam D. Biales, David C. Bencic, Robert W. Flick, Armah Delacruz, Denise A. Gordon, Weichun Huang
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Toxicon: X
Subjects:
Microcystin-LR
Microcystin-RR
RNA-seq
Transcriptomics
ER stress
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2590171020300382

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