Salivary Metabolomics for Systemic Cancer Diagnosis: A Systematic Review
Cancers are the leading cause of death worldwide. The most common cancers include breast, lung, and colorectum. Salivary metabolome profiling is a novel non-invasive method in oncological diagnosis. This systematic review was designed to answer the question “Are salivary metabolites reliable for the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/1/28 |
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| author | Kacper Nijakowski Jakub Zdrojewski Monika Nowak Dawid Gruszczyński Filip Knoll Anna Surdacka |
| author_facet | Kacper Nijakowski Jakub Zdrojewski Monika Nowak Dawid Gruszczyński Filip Knoll Anna Surdacka |
| author_sort | Kacper Nijakowski |
| collection | DOAJ |
| description | Cancers are the leading cause of death worldwide. The most common cancers include breast, lung, and colorectum. Salivary metabolome profiling is a novel non-invasive method in oncological diagnosis. This systematic review was designed to answer the question “Are salivary metabolites reliable for the diagnosis of systemic cancers?”. Following the inclusion and exclusion criteria, nineteen studies were included (according to PRISMA statement guidelines). Changes in salivary metabolome were most commonly determined in patients with breast cancer, gastrointestinal cancers, and lung cancer. Most studies involved unstimulated whole saliva as the diagnostic material, evaluated by different spectroscopic methods. Among the found saliva metabolites, the alterations in the metabolic pathways of amino acids and polyamines were most frequently observed, which showed significant predictive values in oncological diagnostics. The most frequently encountered risks of bias were the absence of data regarding blinding, sample size justification, and randomisation. In conclusion, salivary metabolites seem to be potentially reliable for detecting the most common systemic cancers. However, further research is desirable to confirm these outcomes and to detect new potential metabolic biomarkers in saliva. |
| first_indexed | 2024-03-09T11:43:42Z |
| format | Article |
| id | doaj.art-96acc2b9a6b0492e9d3bbbe9232e870c |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T11:43:42Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-96acc2b9a6b0492e9d3bbbe9232e870c2023-11-30T23:27:50ZengMDPI AGMetabolites2218-19892022-12-011312810.3390/metabo13010028Salivary Metabolomics for Systemic Cancer Diagnosis: A Systematic ReviewKacper Nijakowski0Jakub Zdrojewski1Monika Nowak2Dawid Gruszczyński3Filip Knoll4Anna Surdacka5Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, PolandStudent’s Scientific Group in Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, PolandStudent’s Scientific Group in Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, PolandStudent’s Scientific Group in Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, PolandStudent’s Scientific Group in Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, PolandDepartment of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, PolandCancers are the leading cause of death worldwide. The most common cancers include breast, lung, and colorectum. Salivary metabolome profiling is a novel non-invasive method in oncological diagnosis. This systematic review was designed to answer the question “Are salivary metabolites reliable for the diagnosis of systemic cancers?”. Following the inclusion and exclusion criteria, nineteen studies were included (according to PRISMA statement guidelines). Changes in salivary metabolome were most commonly determined in patients with breast cancer, gastrointestinal cancers, and lung cancer. Most studies involved unstimulated whole saliva as the diagnostic material, evaluated by different spectroscopic methods. Among the found saliva metabolites, the alterations in the metabolic pathways of amino acids and polyamines were most frequently observed, which showed significant predictive values in oncological diagnostics. The most frequently encountered risks of bias were the absence of data regarding blinding, sample size justification, and randomisation. In conclusion, salivary metabolites seem to be potentially reliable for detecting the most common systemic cancers. However, further research is desirable to confirm these outcomes and to detect new potential metabolic biomarkers in saliva.https://www.mdpi.com/2218-1989/13/1/28salivametabolomicsmetabolomemetabolitescancercarcinoma |
| spellingShingle | Kacper Nijakowski Jakub Zdrojewski Monika Nowak Dawid Gruszczyński Filip Knoll Anna Surdacka Salivary Metabolomics for Systemic Cancer Diagnosis: A Systematic Review Metabolites saliva metabolomics metabolome metabolites cancer carcinoma |
| title | Salivary Metabolomics for Systemic Cancer Diagnosis: A Systematic Review |
| title_full | Salivary Metabolomics for Systemic Cancer Diagnosis: A Systematic Review |
| title_fullStr | Salivary Metabolomics for Systemic Cancer Diagnosis: A Systematic Review |
| title_full_unstemmed | Salivary Metabolomics for Systemic Cancer Diagnosis: A Systematic Review |
| title_short | Salivary Metabolomics for Systemic Cancer Diagnosis: A Systematic Review |
| title_sort | salivary metabolomics for systemic cancer diagnosis a systematic review |
| topic | saliva metabolomics metabolome metabolites cancer carcinoma |
| url | https://www.mdpi.com/2218-1989/13/1/28 |
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