Evaluation of cortical and trabecular bone structure of the mandible in patients using L-Thyroxine
Abstract Background Long-term use of L-Thyroxine (LT4), the synthetic thyroxine hormone used for thyroid hormone replacement therapy, is an important risk factor for osteoporosis. The aim of this study was to investigate the differences between mandibular cortical index (MCI) and trabecular bone fra...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-023-03670-z |
| _version_ | 1797451282934398976 |
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| author | Melike Gulec Melek Tassoker Mediha Erturk |
| author_facet | Melike Gulec Melek Tassoker Mediha Erturk |
| author_sort | Melike Gulec |
| collection | DOAJ |
| description | Abstract Background Long-term use of L-Thyroxine (LT4), the synthetic thyroxine hormone used for thyroid hormone replacement therapy, is an important risk factor for osteoporosis. The aim of this study was to investigate the differences between mandibular cortical index (MCI) and trabecular bone fractal dimension (FD) values on panoramic radiographs of patients using LT4 and control subjects. Methods A total of 142 female patients, 71 cases and 71 controls, were analyzed in the study. Ages were matched in case and control groups and the mean age was 36.6 ± 8.2 (18 to 50) years. MCI consisting of C1 (Normal Mandibular Cortex), C2 (Moderately Resorbed Mandibular Cortex) and, C3 (Severely Resorbed Cortex) scores was determined for case and control groups. Fractal analysis was performed using ImageJ on selected regions of interest from the gonial and interdental regions. The box-count method was used to calculate FD values. Wilcoxon signed-rank test, Mann-Whitney U test, and Spearman correlation analysis were applied to compare the measurements. Statistical significance of differences was established at P < 0.05 level. Results FD values did not show statistically significant differences between case and control groups (p > 0.05). The mean FD in the right gonial region was 1.38 ± 0.07 in the case group and 1.38 ± 0.08 in the control group (p = 0.715). The mean FD in the right interdental region was 1.37 ± 0.06 in the cases and 1.36 ± 0.06 in the control group (p = 0.373). The mean FD in the left gonial region was 1.39 ± 0.07 in the cases and 1.39 ± 0.07 in the control group (p = 0.865). The mean FD in the left interdental region is 1.37 ± 0.06 in the cases and 1.38 ± 0.05 in the control group (p = 0.369). The most common MCI score was C1, with 62% in the cases and 83.1% in the control group. MCI scores showed a statistically significant difference between cases and controls (p = 0.016, p < 0.05). While the C2 score was higher in the cases, the C1 score was higher in the controls. Conclusions LT4 use was not associated with the FD of mandibular trabecular bone, but was associated with MCI values of cortical bone. Further studies on larger samples with different imaging modalities and image processing methods are needed. |
| first_indexed | 2024-03-09T14:52:27Z |
| format | Article |
| id | doaj.art-96add4ac72fd410a84351a9f9899917f |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-03-09T14:52:27Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-96add4ac72fd410a84351a9f9899917f2023-11-26T14:25:00ZengBMCBMC Oral Health1472-68312023-11-012311910.1186/s12903-023-03670-zEvaluation of cortical and trabecular bone structure of the mandible in patients using L-ThyroxineMelike Gulec0Melek Tassoker1Mediha Erturk2Department of Dentomaxillofacial Radiology, Karamanoğlu Mehmetbey University Faculty of DentistryDepartment of Dentomaxillofacial Radiology, Necmettin Erbakan University Faculty of DentistryDepartment of Dentomaxillofacial Radiology, Necmettin Erbakan University Faculty of DentistryAbstract Background Long-term use of L-Thyroxine (LT4), the synthetic thyroxine hormone used for thyroid hormone replacement therapy, is an important risk factor for osteoporosis. The aim of this study was to investigate the differences between mandibular cortical index (MCI) and trabecular bone fractal dimension (FD) values on panoramic radiographs of patients using LT4 and control subjects. Methods A total of 142 female patients, 71 cases and 71 controls, were analyzed in the study. Ages were matched in case and control groups and the mean age was 36.6 ± 8.2 (18 to 50) years. MCI consisting of C1 (Normal Mandibular Cortex), C2 (Moderately Resorbed Mandibular Cortex) and, C3 (Severely Resorbed Cortex) scores was determined for case and control groups. Fractal analysis was performed using ImageJ on selected regions of interest from the gonial and interdental regions. The box-count method was used to calculate FD values. Wilcoxon signed-rank test, Mann-Whitney U test, and Spearman correlation analysis were applied to compare the measurements. Statistical significance of differences was established at P < 0.05 level. Results FD values did not show statistically significant differences between case and control groups (p > 0.05). The mean FD in the right gonial region was 1.38 ± 0.07 in the case group and 1.38 ± 0.08 in the control group (p = 0.715). The mean FD in the right interdental region was 1.37 ± 0.06 in the cases and 1.36 ± 0.06 in the control group (p = 0.373). The mean FD in the left gonial region was 1.39 ± 0.07 in the cases and 1.39 ± 0.07 in the control group (p = 0.865). The mean FD in the left interdental region is 1.37 ± 0.06 in the cases and 1.38 ± 0.05 in the control group (p = 0.369). The most common MCI score was C1, with 62% in the cases and 83.1% in the control group. MCI scores showed a statistically significant difference between cases and controls (p = 0.016, p < 0.05). While the C2 score was higher in the cases, the C1 score was higher in the controls. Conclusions LT4 use was not associated with the FD of mandibular trabecular bone, but was associated with MCI values of cortical bone. Further studies on larger samples with different imaging modalities and image processing methods are needed.https://doi.org/10.1186/s12903-023-03670-zHypothyroidismMedicationOsteoporosisMandibular cortical indexFractal dimensionImage processing |
| spellingShingle | Melike Gulec Melek Tassoker Mediha Erturk Evaluation of cortical and trabecular bone structure of the mandible in patients using L-Thyroxine BMC Oral Health Hypothyroidism Medication Osteoporosis Mandibular cortical index Fractal dimension Image processing |
| title | Evaluation of cortical and trabecular bone structure of the mandible in patients using L-Thyroxine |
| title_full | Evaluation of cortical and trabecular bone structure of the mandible in patients using L-Thyroxine |
| title_fullStr | Evaluation of cortical and trabecular bone structure of the mandible in patients using L-Thyroxine |
| title_full_unstemmed | Evaluation of cortical and trabecular bone structure of the mandible in patients using L-Thyroxine |
| title_short | Evaluation of cortical and trabecular bone structure of the mandible in patients using L-Thyroxine |
| title_sort | evaluation of cortical and trabecular bone structure of the mandible in patients using l thyroxine |
| topic | Hypothyroidism Medication Osteoporosis Mandibular cortical index Fractal dimension Image processing |
| url | https://doi.org/10.1186/s12903-023-03670-z |
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