Exposure profile of mercury, lead, cadmium, arsenic, antimony, copper, selenium and zinc in maternal blood, cord blood and placenta: the Tohoku Study of Child Development in Japan
Abstract Background The effects of prenatal exposure to toxic elements on birth outcomes and child development have been an area of concern. This study aimed to assess the profile of prenatal exposure to toxic elements, arsenic (As), bismuth (Bi), cadmium (Cd), mercury (total mercury (THg), methylme...
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| Format: | Article |
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Komiyama Printing Co. Ltd
2019-05-01
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| Series: | Environmental Health and Preventive Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12199-019-0783-y |
| _version_ | 1818501986928033792 |
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| author | Miyuki Iwai-Shimada Satomi Kameo Kunihiko Nakai Kozue Yaginuma-Sakurai Nozomi Tatsuta Naoyuki Kurokawa Shoji F. Nakayama Hiroshi Satoh |
| author_facet | Miyuki Iwai-Shimada Satomi Kameo Kunihiko Nakai Kozue Yaginuma-Sakurai Nozomi Tatsuta Naoyuki Kurokawa Shoji F. Nakayama Hiroshi Satoh |
| author_sort | Miyuki Iwai-Shimada |
| collection | DOAJ |
| description | Abstract Background The effects of prenatal exposure to toxic elements on birth outcomes and child development have been an area of concern. This study aimed to assess the profile of prenatal exposure to toxic elements, arsenic (As), bismuth (Bi), cadmium (Cd), mercury (total mercury (THg), methylmercury (MHg), inorganic mercury (IHg)), lead (Pb), antimony (Sb) and tin (Sn), and essential trace elements, copper (Cu), selenium (Se) and zinc (Zn), using the maternal blood, cord blood and placenta in the Tohoku Study of Child Development of Japan (N = 594–650). Methods Inductively coupled plasma mass spectrometry was used to determine the concentrations of these elements (except mercury). Levels of THg and MeHg were measured using cold vapour atomic absorption spectrophotometry and a gas chromatograph-electron capture detector, respectively. Results Median concentrations (25th–75th) of As, Cd, Pb, Sb, Sn and THg in the maternal blood were 4.06 (2.68–6.81), 1.18 (0.74–1.79), 10.8 (8.65–13.5), 0.2 (0.06–0.40) and 0.2 (0.1–0.38) ng mL−1 and 5.42 (3.89–7.59) ng g−1, respectively. Median concentrations (25th–75th) of As, Cd, Pb, Sb, Sn and THg in the cord blood were 3.68 (2.58–5.25), 0.53 (0.10–1.25), 9.89 (8.02–12.5), 0.39 (0.06–0.92) and 0.2 (0.2–0.38) ng mL−1 and 9.96 (7.05–13.8) ng g−1, respectively. Conclusions THg and Sb levels in the cord blood were twofold higher than those in the maternal blood. Cord blood to maternal blood ratios for As, Cd and Sb widely varied between individuals. To understand the effects of prenatal exposure, further research regarding the variations of placental transfer of elements is necessary. |
| first_indexed | 2024-12-10T21:03:47Z |
| format | Article |
| id | doaj.art-96b0862793ee465c92897f4d1ac4d609 |
| institution | Directory Open Access Journal |
| issn | 1342-078X 1347-4715 |
| language | English |
| last_indexed | 2024-12-10T21:03:47Z |
| publishDate | 2019-05-01 |
| publisher | Komiyama Printing Co. Ltd |
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| series | Environmental Health and Preventive Medicine |
| spelling | doaj.art-96b0862793ee465c92897f4d1ac4d6092022-12-22T01:33:41ZengKomiyama Printing Co. LtdEnvironmental Health and Preventive Medicine1342-078X1347-47152019-05-0124111110.1186/s12199-019-0783-yExposure profile of mercury, lead, cadmium, arsenic, antimony, copper, selenium and zinc in maternal blood, cord blood and placenta: the Tohoku Study of Child Development in JapanMiyuki Iwai-Shimada0Satomi Kameo1Kunihiko Nakai2Kozue Yaginuma-Sakurai3Nozomi Tatsuta4Naoyuki Kurokawa5Shoji F. Nakayama6Hiroshi Satoh7Centre for Health and Environmental Risk Research, National Institute for Environmental StudiesDepartment of Nutrition, College of Nutrition, Koshien UniversityDepartment of Development and Environmental Medicine, Tohoku University Graduate School of MedicineDepartment of Human Health and Nutrition, Faculty of Comprehensive Human Sciences, Shokei Gakuin UniversityDepartment of Development and Environmental Medicine, Tohoku University Graduate School of MedicineMiyagi University of EducationCentre for Health and Environmental Risk Research, National Institute for Environmental StudiesTohoku UniversityAbstract Background The effects of prenatal exposure to toxic elements on birth outcomes and child development have been an area of concern. This study aimed to assess the profile of prenatal exposure to toxic elements, arsenic (As), bismuth (Bi), cadmium (Cd), mercury (total mercury (THg), methylmercury (MHg), inorganic mercury (IHg)), lead (Pb), antimony (Sb) and tin (Sn), and essential trace elements, copper (Cu), selenium (Se) and zinc (Zn), using the maternal blood, cord blood and placenta in the Tohoku Study of Child Development of Japan (N = 594–650). Methods Inductively coupled plasma mass spectrometry was used to determine the concentrations of these elements (except mercury). Levels of THg and MeHg were measured using cold vapour atomic absorption spectrophotometry and a gas chromatograph-electron capture detector, respectively. Results Median concentrations (25th–75th) of As, Cd, Pb, Sb, Sn and THg in the maternal blood were 4.06 (2.68–6.81), 1.18 (0.74–1.79), 10.8 (8.65–13.5), 0.2 (0.06–0.40) and 0.2 (0.1–0.38) ng mL−1 and 5.42 (3.89–7.59) ng g−1, respectively. Median concentrations (25th–75th) of As, Cd, Pb, Sb, Sn and THg in the cord blood were 3.68 (2.58–5.25), 0.53 (0.10–1.25), 9.89 (8.02–12.5), 0.39 (0.06–0.92) and 0.2 (0.2–0.38) ng mL−1 and 9.96 (7.05–13.8) ng g−1, respectively. Conclusions THg and Sb levels in the cord blood were twofold higher than those in the maternal blood. Cord blood to maternal blood ratios for As, Cd and Sb widely varied between individuals. To understand the effects of prenatal exposure, further research regarding the variations of placental transfer of elements is necessary.http://link.springer.com/article/10.1186/s12199-019-0783-yCord bloodPlacentaMaternal bloodTrace elementMetal |
| spellingShingle | Miyuki Iwai-Shimada Satomi Kameo Kunihiko Nakai Kozue Yaginuma-Sakurai Nozomi Tatsuta Naoyuki Kurokawa Shoji F. Nakayama Hiroshi Satoh Exposure profile of mercury, lead, cadmium, arsenic, antimony, copper, selenium and zinc in maternal blood, cord blood and placenta: the Tohoku Study of Child Development in Japan Environmental Health and Preventive Medicine Cord blood Placenta Maternal blood Trace element Metal |
| title | Exposure profile of mercury, lead, cadmium, arsenic, antimony, copper, selenium and zinc in maternal blood, cord blood and placenta: the Tohoku Study of Child Development in Japan |
| title_full | Exposure profile of mercury, lead, cadmium, arsenic, antimony, copper, selenium and zinc in maternal blood, cord blood and placenta: the Tohoku Study of Child Development in Japan |
| title_fullStr | Exposure profile of mercury, lead, cadmium, arsenic, antimony, copper, selenium and zinc in maternal blood, cord blood and placenta: the Tohoku Study of Child Development in Japan |
| title_full_unstemmed | Exposure profile of mercury, lead, cadmium, arsenic, antimony, copper, selenium and zinc in maternal blood, cord blood and placenta: the Tohoku Study of Child Development in Japan |
| title_short | Exposure profile of mercury, lead, cadmium, arsenic, antimony, copper, selenium and zinc in maternal blood, cord blood and placenta: the Tohoku Study of Child Development in Japan |
| title_sort | exposure profile of mercury lead cadmium arsenic antimony copper selenium and zinc in maternal blood cord blood and placenta the tohoku study of child development in japan |
| topic | Cord blood Placenta Maternal blood Trace element Metal |
| url | http://link.springer.com/article/10.1186/s12199-019-0783-y |
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