Plasma cells arise from differentiation of clonal lymphocytes and secrete IgM in Waldenström macroglobulinemia

Plasma cells arise from differentiation of clonal lymphocytes and secrete IgM in Waldenström macroglobulinemia

Summary: Waldenström macroglobulinemia (WM) is characterized by bone marrow infiltration with malignant lymphoplasmacytic cells (LPCs), a smaller population of plasma cells (PCs), and hypersecretion of IgM monoclonal protein. Here, we show that CD45low, CD38+, and CD138+ PCs and CD45high, CD38−, CD1...

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Bibliographic Details
Main Authors: Jun Hee Lim, James Q. Wang, Fiona Webb, Kartik Saxena, Daniel Enosi Tuipulotu, Abhimanu Pandey, Si Ming Man, Dipti Talaulikar
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:iScience
Subjects:
Immunology
Immune system disorder
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222011282

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