Does Radiofrequency Ablation Induce Neoplastic Changes in Benign Thyroid Nodules: A Preliminary Study
BackgroundTo evaluate the clinical feasibility of radiofrequency ablation (RFA) of benign thyroid nodules along with cytomorphological alteration, and any malignant transformation through biopsy.MethodsThe data were retrospectively collected between April 2008 and June 2013 and core needle biopsy (C...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2019-05-01
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| Series: | Endocrinology and Metabolism |
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| Online Access: | https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-34-169.pdf |
| _version_ | 1811334080535461888 |
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| author | Su Min Ha Jun Young Shin Jung Hwan Baek Dong Eun Song Sae Rom Chung Young Jun Choi Jeong Hyun Lee |
| author_facet | Su Min Ha Jun Young Shin Jung Hwan Baek Dong Eun Song Sae Rom Chung Young Jun Choi Jeong Hyun Lee |
| author_sort | Su Min Ha |
| collection | DOAJ |
| description | BackgroundTo evaluate the clinical feasibility of radiofrequency ablation (RFA) of benign thyroid nodules along with cytomorphological alteration, and any malignant transformation through biopsy.MethodsThe data were retrospectively collected between April 2008 and June 2013 and core needle biopsy (CNB) was performed on 16 benign thyroid nodules previously treated using RFA. The parameters of the patients were compared, between the time of enrollment and the last follow-up examination, using linear mixed model statistical analysis.ResultsNo atypical cells or neoplastic transformation were detected in the undertreated peripheral portion of treated benign nodules on the CNB specimen. RFA altered neither the thyroid capsule nor the thyroid tissue adjacent to the treated area. On histopathological examinations, we observed 81.2% acellular hyalinization, which was the most common finding. After a mean follow-up period of over 5 years, the mean volume of thyroid nodule had decreased to 6.4±4.2 mL, with a reduction rate of 81.3%±5.8% (P<0.0001).ConclusionRFA is a technically feasible treatment method for benign thyroid nodules, with no carcinogenic effect or tissue damage of the normal thyroid tissue adjacent to the RFA-treated zone. |
| first_indexed | 2024-04-13T17:02:25Z |
| format | Article |
| id | doaj.art-96b7e0d2e3f54926bf1f8cdd5983b952 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-04-13T17:02:25Z |
| publishDate | 2019-05-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-96b7e0d2e3f54926bf1f8cdd5983b9522022-12-22T02:38:36ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782019-05-0134216917810.3803/EnM.2019.34.2.169Does Radiofrequency Ablation Induce Neoplastic Changes in Benign Thyroid Nodules: A Preliminary StudySu Min Ha0Jun Young Shin1Jung Hwan Baek2Dong Eun Song3Sae Rom Chung4Young Jun Choi5Jeong Hyun Lee6Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicinee, Seoul, .KoreaDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Radiology and the Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Radiology and the Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Radiology and the Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaDepartment of Radiology and the Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, .KoreaBackgroundTo evaluate the clinical feasibility of radiofrequency ablation (RFA) of benign thyroid nodules along with cytomorphological alteration, and any malignant transformation through biopsy.MethodsThe data were retrospectively collected between April 2008 and June 2013 and core needle biopsy (CNB) was performed on 16 benign thyroid nodules previously treated using RFA. The parameters of the patients were compared, between the time of enrollment and the last follow-up examination, using linear mixed model statistical analysis.ResultsNo atypical cells or neoplastic transformation were detected in the undertreated peripheral portion of treated benign nodules on the CNB specimen. RFA altered neither the thyroid capsule nor the thyroid tissue adjacent to the treated area. On histopathological examinations, we observed 81.2% acellular hyalinization, which was the most common finding. After a mean follow-up period of over 5 years, the mean volume of thyroid nodule had decreased to 6.4±4.2 mL, with a reduction rate of 81.3%±5.8% (P<0.0001).ConclusionRFA is a technically feasible treatment method for benign thyroid nodules, with no carcinogenic effect or tissue damage of the normal thyroid tissue adjacent to the RFA-treated zone.https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-34-169.pdfThyroid noduleRadiofrequency ablationUltrasonographyPathologyBiopsy, large-core needle |
| spellingShingle | Su Min Ha Jun Young Shin Jung Hwan Baek Dong Eun Song Sae Rom Chung Young Jun Choi Jeong Hyun Lee Does Radiofrequency Ablation Induce Neoplastic Changes in Benign Thyroid Nodules: A Preliminary Study Endocrinology and Metabolism Thyroid nodule Radiofrequency ablation Ultrasonography Pathology Biopsy, large-core needle |
| title | Does Radiofrequency Ablation Induce Neoplastic Changes in Benign Thyroid Nodules: A Preliminary Study |
| title_full | Does Radiofrequency Ablation Induce Neoplastic Changes in Benign Thyroid Nodules: A Preliminary Study |
| title_fullStr | Does Radiofrequency Ablation Induce Neoplastic Changes in Benign Thyroid Nodules: A Preliminary Study |
| title_full_unstemmed | Does Radiofrequency Ablation Induce Neoplastic Changes in Benign Thyroid Nodules: A Preliminary Study |
| title_short | Does Radiofrequency Ablation Induce Neoplastic Changes in Benign Thyroid Nodules: A Preliminary Study |
| title_sort | does radiofrequency ablation induce neoplastic changes in benign thyroid nodules a preliminary study |
| topic | Thyroid nodule Radiofrequency ablation Ultrasonography Pathology Biopsy, large-core needle |
| url | https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-34-169.pdf |
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